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您的检索式：作者名="LU Guijuan"
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| 1 | Effects of Specimen Height on the Acoustic Emission Rate Value 'a' for Cement Mortar显示文摘In order to study the size effect on the AE rate 'a' value,three kinds of mix ratios were set up by different particle sizes and water cement ratios,45 cement mortar specimens with five different heights were tested under axial compression.And the whole damage processes were monitored by full-digital acoustic emission acquisition system,followed by an analysis of mechanical behavior and AE activity.The experimental results show that the height of the cement specimen has significant effects on the compressive strength and the acoustic emission rate 'a' value,but a slight effect on the accumulated AE hits number,which is analyzed from aspects of failure process of cement mortar specimens. | 王岩 HU Hongxiang LU Guijuan CHEN Shijie LIU Shaojun WANG Yao | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 1 |
| 2 | NRF1-mediated microglial activation triggers high-altitude cerebral edema显示文摘High-altitude cerebral edema(HACE)is a potentially fatal encephalopathy associated with a time-dependent exposure to the hypobaric hypoxia of altitude.The formation of HACE is affected by both vasogenic and cytotoxic edema.The over-activated microglia potentiate the damage of blood-brain barrier(BBB)and exacerbate cytotoxic edema.In light with the activation of microglia in HACE,we aimed to investigate whether the over-activated microglia were the key turning point of acute mountain sickness to HACE.In in vivo experiments,by exposing mice to hypobaric hypoxia(7000 m above sea level)to induce HACE model,we found that microglia were activated and migrated to blood vessels.Microglia depletion by PLX5622 obviously relieved brain edema.In in vitro experiments,we found that hypoxia induced cultured microglial activation,leading to the destruction of endothelial tight junction and astrocyte swelling.Up-regulated nuclear respiratory factor 1(NRF1)accelerated pro-inflammatory factors through transcriptional regulation on nuclearfactorkappa B p65(NF-kB p65)and mitochondrial transcription factorA(TFAM)in activated microglia under hypoxia.NRF1 also up-regulated phagocytosis by transcriptional regulation on caveolin-1(CAV-1)and adaptorrelated protein complex 2 subunit beta(AP2B1).The present study reveals a new mechanism in HACE:hypoxia over-activates microglia through up-regulation of NRF1,which both induces inflammatory response through transcriptionally activating NF-kB p65 and TFAM,and enhances phagocytic function through up-regulation of CAV-1 and AP2B1;hypoxia-activatedmicroglia destroy the integrity of BBB and release pro-inflammatory factors that eventually induce HACE. | Xueting Wang Guijuan Chen Baolan Wan Zhangji Dong Yan Xue Qianqian Luo Dan Wang Yapeng Lu Li Zhu | 2022 | Journal of Molecular Cell Biology2022，14，5： | 1 |
| 3 | Neuropeptide S mainly from Kolliker-Fuse nucleus promotes wakefulness through activation of cognate receptor-neurons in the paraventricular thalamus显示文摘Neuropeptide S(NPS)is a neuromodulator that concentratively expressed in the Kolliker Fuse nucleus(KF)and pericoerulear area(Peri-LC)in mice.NPS and its receptor(NPSR)system participates multiple biological effects.The paraventricular thalamus(PVT),a newly identified area that critical for wakefulness,highly expressed NPSR suggesting that NPS NPSR system may be involved in the regulation of sleep-waking states through PVT.The present study was undertaken to investigate effects of NPS on the sleep-waking states through PVT. | Shao Yufeng Cai Chenchen Chen Yunong Ren Yanli Lu Guijuan Xie Junfan Hou Yiping | 2021 | 解剖学杂志2021，44，S01： | 0 |
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