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| 1 | Aftershock sequence relocation of the 2021 M_(S)7.4 Maduo Earthquake, Qinghai, China显示文摘The 2021 Qinghai Maduo M_(S)7.4 earthquake was one of the strongest earthquakes that occurred in the Bayan Har block of the Tibetan Plateau during the past 30 years,which spatially filled in the gap of strong earthquake in the eastern section of the northern block boundary.In this study,the aftershock sequence within 8 days after the mainshock was relocated by double difference algorithm.The results show that the total length of the aftershock zone is approximately 170 km;the mainshock epicenter is located in the center of the aftershock zone,indicating a bilateral rupture.The aftershocks are mainly distributed along NWW direction with an overall strike of 285°.The focal depth profiles indicate that the seismogenic fault is nearly vertical and dips to southwest or northeast in different sections,indicating a complex geometry.There is an aftershock gap located to the southeast of the mainshock epicenter with a scale of approximately 20 km.At the eastern end of the aftershock zone,horsetaillike branch faults show the terminal effect of a large strike-slip fault.There is a NW-trending aftershock zone on the north side of the western section,which may be a branch fault triggered by the mainshock.The location of the aftershock sequence is close to the eastern section of the Kunlun Mountain Pass-Jiangcuo(KMPJ)fault.The sequence overlaps well with surface trace of the KMPJ fault.We speculate that the KMPJ fault is the main seismogenic fault of the M_(S)7.4 Maduo earthquake. | Weilai WANG Lihua FANG Jianping WU Hongwei TU Liyi CHEN Guijuan LAI Long ZHANG | 2021 | Science China Earth Sciences2021，64，8： | 11 |
| 2 | External use of Ruyanneixiao cream efficiently blocks precancerous mammary lesions by interfering with glycolysis induced by inhibition of hypoxia inducible factor-1α, hexokinase 2, phosphofructokinase, and pyruvate kinase M2 expression显示文摘OBJECTIVE:To investigate the effect of Ruyanneixiao cream(RYNX) on the expression of hypoxia inducible factor-1α(HIF-1α), hexokinase 2(HK2),phosphofructokinase(PFK), and pyruvate kinase M2(PKM2) mRNA and protein in MCF-10 AT cells and in an animal model of precancerous mammary lesions.METHODS:Following treatment of MCF-10 AT cells with RYNX, tamoxifen(TAM) and YC-1 for 48 h,HIF-1α, HK2, PFK, PKM2 mRNA and protein expression was analyzed.Fifty female SD rats were randomly divided into control, model, TAM, and highand low-dose RYNX groups, with 10 rats in each group.A precancerous mammary lesion model was established for all groups except the control group.High-and low-dose RYNX cream containing TAM was coated on the breasts of animals in the corresponding groups.The rat mammary tissue was removed in the 10 th week and HIF-1α, HK2, PFK,PKM2 mRNA and protein was analyzed.RESULTS:In vitro analyses demonstrated that, compared with the matrix group, HIF-1α, HK2, PFK,PKM2 mRNA and protein expression was significantly decreased in the RYNX group(P < 0.05).Compared with the YC-1 + RYNX group, HK2, PFK,and PKM2 protein expression was significantly reduced in the RYNX group.HIF-1α, HK2, PFK, and PKM2 protein expression was increased significantly in the model group(P < 0.05) compared with the control group, while HIF-1α, HK2, PFK, and PKM2 mRNA and protein expression was significantly decreased in both the high-and low-dose RYNX groups(P < 0.05), with the effect being greater in the high-dose group.CONCLUSION:RYNX can block precancerous breast lesions by decreasing the expression of HK2,PFK, and PKM2 mRNA and protein via inhibition of HIF-1α mRNA and protein overexpression in a dose-dependent manner. | Li Xiaobo Ma Min Zhang Guijuan Ma Yi Liao Rui Chen Ruixue Yan Xianxin Bie Fengjie Huang Maojie Liang Shijie | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 5 |
| 3 | HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas显示文摘Hepatocellular carcinoma(HCC) is highly heterogeneous in nature and has been one of the most common cancer types worldwide. To ensure repeatability of identified gene expression patterns and comprehensively annotate the transcriptomes of HCC, we carefully curated 15 public HCC expression datasets that cover around 4000 clinical samples and developed the database HCCDB to serve as a one-stop online resource for exploring HCC gene expression with userfriendly interfaces. The global differential gene expression landscape of HCC was established by analyzing the consistently differentially expressed genes across multiple datasets. Moreover, a 4 D metric was proposed to fully characterize the expression pattern of each gene by integrating data from The Cancer Genome Atlas(TCGA) and Genotype-Tissue Expression(GTEx). To facilitate a comprehensive understanding of gene expression patterns in HCC, HCCDB also provides links to third-party databases on drug, proteomics, and literatures, and graphically displays the resultsfrom computational analyses, including differential expression analysis, tissue-specific and tumorspecific expression analysis, survival analysis, and co-expression analysis. HCCDB is freely accessible at http://gffzzbcb113a830484641ho6cx0nk0005v6kbv.ffgz.tsg.suse.edu.cn/database/hccdb. | Qiuyu Lian Shicheng Wang Guchao Zhang Dongfang Wang Guijuan Luo Jing Tang Lei Chen Jin Gu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 5 |
| 4 | Constitutive Modeling of Slip, Twinning and Detwinning for Mg Alloy and Inhomogeneous Evolution of Microstructure显示文摘 | Yuan Chen Guijuan Hu Yongting Lan Keshi Zhang Ganwei Cai | 2018 | Acta Mechanica Solida Sinica2018，31，4： | 3 |
| 5 | Effects of Specimen Height on the Acoustic Emission Rate Value 'a' for Cement Mortar显示文摘In order to study the size effect on the AE rate 'a' value,three kinds of mix ratios were set up by different particle sizes and water cement ratios,45 cement mortar specimens with five different heights were tested under axial compression.And the whole damage processes were monitored by full-digital acoustic emission acquisition system,followed by an analysis of mechanical behavior and AE activity.The experimental results show that the height of the cement specimen has significant effects on the compressive strength and the acoustic emission rate 'a' value,but a slight effect on the accumulated AE hits number,which is analyzed from aspects of failure process of cement mortar specimens. | 王岩 HU Hongxiang LU Guijuan CHEN Shijie LIU Shaojun WANG Yao | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 1 |
| 6 | Microstructure and hardness investigation of 17-4PH stainless steel by laser quenching 显示文摘 | Chen Zhaoyun Zhou Guijuan Chen Zhonghua | 2012 | Mater SciEng A2012，534，： | 1 |
| 7 | Rhodauricanol A, an analgesic diterpenoid with an unprecedented5/6/5/7 tetracyclic system featuring a unique16-oxa-tetracyclo[11.2.1.0^(1,5).0^(7,13)]hexadecane core from Rhododendron dauricum显示文摘A novel diterpenoid with an unprecedented 5/6/5/7 tetracyclic system, rhodauricanol A(1), five new grayanane-derived diterpenoids, dauricanols A-E(2-6), and five known ones(7-11) were isolated from the flowers of Rhododendron dauricum. Rhodauricanol A(1) possesses a unique 5/6/5/7 tetracyclic ring system featuring a 16-oxa-tetracyclo[11.2.1.0^(1,5).0^(7,13)]hexadecane core. Dauricanols A-C(2-4) are the first1,3-dioxolane conjugates of grayanane diterpenoids and 5-hydroxymethylfurfural and vanillin, respectively, and dauricanols D(5) and E(6) represent the first examples of 6-deoxy-1,5-seco-grayanane diterpenoids. Their structures were determined by spectroscopic methods, quantum chemical calculation including ^(13)C NMR-DP4+ analysis and ECD calculation, and single-crystal X-ray diffraction analysis. Plausible biosynthetic pathways for 1-4 were proposed. All the isolates showed significant analgesic activities,and dauricanols B(3) and C(4) showed more potent analgesic activities than the positive control, morphine. | Yuanyuan Feng Suqin Zha Hanqi Zhang Biao Gao Guijuan Zheng Pengfei Jin Yingyi Chen Guangmin Yao | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 8 | Programmed 6-Step Approach of Improved Liposuction-Curettage for Axillary Bromhidrosis显示文摘Background Liposuction-curettage is a long-standing and effective treatment for axillary bromhidrosis.However,residual malodor and skin necrosis typically occur following this treatment.Therefore,we improved this method to ensure fewer complications and better outcomes.Here,we have presented our programmed 6-step approach of improved liposuction-curettage.Methods The programmed 6-step approach of improved liposuction-curettage was used to remove the axillary apocrine glands.We used pointed and obtuse cannulas designed for liposuction-curettage.Results Patients treated using the programmed 6-step approach of improved liposuctioncurettage did not experience any serious complications or residual malodor.Conclusion The programmed 6-step approach of improved liposuction-curettage was more effective than traditional surgery with respect to the treatment of axillary bromhidrosis. | Yanqi LIU Yanmeng PAN Minxia ZHANG Li CHEN Fawei XU Hongfang MA Xing HE Ying HU Guijuan HE Jiaqin CAI Weiqiang TAN | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，3： | 1 |
| 9 | NRF1-mediated microglial activation triggers high-altitude cerebral edema显示文摘High-altitude cerebral edema(HACE)is a potentially fatal encephalopathy associated with a time-dependent exposure to the hypobaric hypoxia of altitude.The formation of HACE is affected by both vasogenic and cytotoxic edema.The over-activated microglia potentiate the damage of blood-brain barrier(BBB)and exacerbate cytotoxic edema.In light with the activation of microglia in HACE,we aimed to investigate whether the over-activated microglia were the key turning point of acute mountain sickness to HACE.In in vivo experiments,by exposing mice to hypobaric hypoxia(7000 m above sea level)to induce HACE model,we found that microglia were activated and migrated to blood vessels.Microglia depletion by PLX5622 obviously relieved brain edema.In in vitro experiments,we found that hypoxia induced cultured microglial activation,leading to the destruction of endothelial tight junction and astrocyte swelling.Up-regulated nuclear respiratory factor 1(NRF1)accelerated pro-inflammatory factors through transcriptional regulation on nuclearfactorkappa B p65(NF-kB p65)and mitochondrial transcription factorA(TFAM)in activated microglia under hypoxia.NRF1 also up-regulated phagocytosis by transcriptional regulation on caveolin-1(CAV-1)and adaptorrelated protein complex 2 subunit beta(AP2B1).The present study reveals a new mechanism in HACE:hypoxia over-activates microglia through up-regulation of NRF1,which both induces inflammatory response through transcriptionally activating NF-kB p65 and TFAM,and enhances phagocytic function through up-regulation of CAV-1 and AP2B1;hypoxia-activatedmicroglia destroy the integrity of BBB and release pro-inflammatory factors that eventually induce HACE. | Xueting Wang Guijuan Chen Baolan Wan Zhangji Dong Yan Xue Qianqian Luo Dan Wang Yapeng Lu Li Zhu | 2022 | Journal of Molecular Cell Biology2022，14，5： | 1 |
| 10 | Mierostructure and hardness investigation of 17-4PH stainless steel by laser quenching显示文摘 | CHEN Zhaoyun ZHOU Guijuan CHEN Zhonghua | 2012 | Material Science and Engineering2012，534，： | 1 |
| 11 | Discrimination Between Broadband Underwater Target Echo and Reverberation Based on Signal Spectral Flatness Feature显示文摘Reverberation is the major interference of active detection, discrimination between target echo and reverberation is difficult when the reverberation is very strong. For the distinguishing of underwater target echo with strong interference, the modulation feature of echo and reverberation spectrum are characterized by signal spectral flatness measure, and the relationship between signal spectral flatness and target physical properties are theoretically formed. A method of discrimination between broadband underwater target echo and reverberation that based on signal spectral flatness characteristics difference is proposed and studied. Sea experiment results of complex underwater target broadband acoustic scattering have shown that signal spectral flatness characteristics of underwater target broadband echo and reverberation have obvious differences. Target echo and reverberation can be well distinguished using the proposed method. | CHEN Yunfei LI Sheng JIA Bing ZHANG Yang WANG Zhenshan LI Guijuan | 2019 | Chinese Journal of Electronics2019，28，3： | 0 |
| 12 | A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection显示文摘HepatoBiliary Surg Nutr 2021;10(4):464-475|http://gffzz4205af39ffde493eho6cx0nk0005v6kbv.ffgz.tsg.suse.edu.cn/10.21037/hbsn.2020.01.07 Original Article A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection Seogsong Jeong1,2#,Guijuan Luo2,3#,Qiang Gao4#,Jing Chen2,3#,Xiaolong Liu5,Liangqing Dong4,Yongjie Zhang6,Feng Shen7,Qingbao Cheng8,Chengjun Sui9,Jingfeng Liu5,Hongyang Wang2,3,Qiang Xia1,Lei Chen2,101Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;2International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,Shanghai,China;3National Center for Liver Cancer,Shanghai,China;4Department of Liver Surgery and Transplantation,Liver Cancer Institute,Zhongshan Hospital,and Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education),Fudan University,Shanghai,China;5Mengchao Hepatobiliary Hospital,Fujian Medical University,Fuzhou,China;6Biliary Tract Department II,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;7Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;8Biliary Tract Department I,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;9Department of Special Medical Care&Liver Transplantation,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;10Shanghai Cancer Center,Shanghai Medical College,Fudan University;Shanghai,China Contributions:(I)Conception and design:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(II)Administrative support:All authors;(III)Provision of study materials or patients:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(IV)Collection and assembly of data:All authors;(V)Data analysis and interpretation:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(VI)Manuscript writing:All authors;(VII)Final approval of manuscript:All authors.#These authors contributed equally to this work.Correspondence to:Lei Chen;Hongyang Wang.International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,225 Changhai Road,Shanghai 200438,China.Email:chenlei@smmu.edu.cn;hywangk@vip.sina.com;Qiang Xia.Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,160 Pujian Road,Shanghai 200127,China.Email:xiaqiang@shsmu.edu.cn. | Seogsong Jeong Guijuan Luo Qiang Gao Jing Chen Xiaolong Liu Liangqing Dong Yongjie Zhang Feng Shen Qingbao Cheng Chengjun Sui Jingfeng Liu Hongyang Wang Qiang Xia Lei Chen | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 0 |
| 13 | Neuropeptide S mainly from Kolliker-Fuse nucleus promotes wakefulness through activation of cognate receptor-neurons in the paraventricular thalamus显示文摘Neuropeptide S(NPS)is a neuromodulator that concentratively expressed in the Kolliker Fuse nucleus(KF)and pericoerulear area(Peri-LC)in mice.NPS and its receptor(NPSR)system participates multiple biological effects.The paraventricular thalamus(PVT),a newly identified area that critical for wakefulness,highly expressed NPSR suggesting that NPS NPSR system may be involved in the regulation of sleep-waking states through PVT.The present study was undertaken to investigate effects of NPS on the sleep-waking states through PVT. | Shao Yufeng Cai Chenchen Chen Yunong Ren Yanli Lu Guijuan Xie Junfan Hou Yiping | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 14 | Estimation of target depth using deep-sea echo multipath structure matching显示文摘This paper presents a method to estimate the depth of deep-sea target by matching the time delay and amplitude structure of echo multipath highlight clusters.The echo structure is the convolution of two-way channel transfer function as well as the acoustic scattering function of the target,which shows the characteristics of deep-sea highlight clusters when the target is close to the sea surface or near the sea bottom.The time delay and amplitude structure of highlight clusters are related to the target depth,which can be used to estimate the target depth.A method of matching estimation of target depth on range-depth grid using nonlinear programming cost function is established.The mismatch effects of inter-cluster time delay interval deviation and sea water sound velocity profile deviation on matching estimation are simulated and analyzed.The results of a winter experiment in the South China Sea illustrate that when the water depth is 1 km and distance is 5–8 km,the echo of target is 40 m underwater,there are three highlight clusters with a time interval of about 0.3 s,with the error range of target depth matching estimation being 0–65 m. | ZHANG Fengzhen LI Guijuan HU Wenshuai HU Chen | 2023 | Chinese Journal of Acoustics2023，42，3： | 0 |
| 15 | Three-dimensional S-wave velocity structure of the crust and upper mantle for the normal fault system beneath the Yinchuan Basin from joint inversion of receiver function and surface wave显示文摘A series of parallel normal faults are distributed in the Helan Mountain-Yinchuan Basin tectonic belt,where a historical M8.0 earthquake occurred.It is rare that such a great earthquake occurs in a normal fault system within the continent.To deeply understand the fine structure of the normal fault system,we deployed 104 broadband temporary stations near the system,collected data from permanent stations and other temporary stations nearby,and obtained the high-precision threedimensional S-wave velocity structure beneath 206 stations via joint inversion of receiver function and surface wave.A typical graben-in-graben feature bounded by four major faults was identified in the Yinchuan Basin.We analyzed the seismicity in the normal fault system and found a seismic strip in the southern part of the basin,where there are significant changes in the sedimentary thickness,which is speculated to be the southern boundary of the normal fault system.There are significant differences in the crustal thickness and velocity structure in the crust on both sides of the boundary between the Helan Mountain and the Yinchuan Basin,and a low-velocity zone was identified in the upper mantle beneath this boundary,which could be related to the fact that the Helan Mountain-Yinchuan Basin tectonic belt is located between the Alxa Block and the Ordos Block.The M8.0 Yinchuan-Pingluo earthquake occurred at the junction of four major faults in the Yinchuan Basin,which was located in the high-velocity zone near the velocity transition zone at the basin-mountain boundary.The low-velocity zone in the upper mantle beneath this boundary may have promoted the nucleation of this earthquake.Based on evidence from geological drilling,micro seismicity,the regional stress field,and the velocity models obtained in this study,it is inferred that the eastern piedmont fault zone of the Helan Mountain was the seismogenic fault of the 1739 M8.0 Yinchuan-Pingluo earthquake. | Weilai WANG Guangyao CAI Guijuan LAI Xianwei ZENG Jingjing BAO Long ZHANG Jun SU Mingfei CHEN | 2023 | Science China Earth Sciences2023，66，5： | 0 |
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