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| 1 | Studies on the Relationship between Neuroendocrine Cellular Differentiation in Gastric Cancers and Post-operative Survival Time显示文摘OBJECTIVE To examine the ultrastructure of gastric cancer cel s by the electron microscope,in order to assess the relationship between neuroendocrine differentiation and post-operative survival time. METHODS NSE,Syn and CgA immunohistochemical labeling was conducted in 168 cases with a common-type of gastric cancer.Electron microscopy was performed in 80 cases with positive immunohistochemical labeling. These cases were fol owed-up for over 5 years and the post-operative survival data analyzed. RESULTS Neuroendocrine granules were found by electron microscopy in 39 cases.The rate of neuroendocrine differentiation found was 23% (39/168),using routine diagnostic criteria and electron microscopy(REM). The post-operative survival time of gastric cancer patients with neuroendocrine differentiation was significantly shorter(P=0.0032)compared to those without neuroendocrine differentiation. CONCLUSION It is of significant clinical importance to determine if the neuroendocrine cells are differentiated in gastric cancers.The gastric cancer patients with neuroendocrine differentiation have a shorter post-operative survival time and a poorer prognosis.Electron microscopy is a reliable method of providing a diagnosis. | Song He Qiao Yan Xudong Chen Jianbing Zhang Xiaoyun Lu Hongjia Pan Li Chen | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 2 |
| 2 | Morphological, crystalline, thermal and physicochemical properties of cellulose nanocrystals obtained from sweet potato residue显示文摘 | Hongjia Lu Yu Gui Longhui Zheng Xiong Liu | 2013 | Food Research International2013，，1： | 1 |
| 3 | Tianhe- 1A Interconnect and Message Passing Services显示文摘 | Min Xie Yutong Lu Kerfei Wang Lu Liu Hongjia Cao | 2012 | IEEE Micro2012，32，1： | 1 |
| 4 | Morphological, crystalline, thermal and physicochemical properties of cellulose nanocrystals obtained from sweet potato residue显示文摘 | LU Hongjia GUI Yu ZHENG Longhui | 2013 | Food Research International2013，50，1： | 1 |
| 5 | Detection and Comparison of Structure and Function of Wild-type Pneumolysin and Its Novel Mutant PIyM2显示文摘 | SUN Tianxu HOU Hongjia LU Jingcai XU Man GU Tiejun WANG Dandan DONG Yunliang JIANG Chunlai KONG Wei WUYongge | 2015 | Chemical Research in Chinese Universities2015，31，4： | 1 |
| 6 | BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models显示文摘t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine production.Therefore,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great interest.However,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy.Here,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell function.In addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity.In the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook effect.Furthermore,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.Taken together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation. | Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wangl Ye Liu | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 7 | Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection显示文摘The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS). | Hong Liu Haiyang Li Lu Han Yingyuan Zhang Ying Wu Liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu Lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators | 2023 | The Innovation2023，4，4： | 0 |
| 8 | Modeling the Spatial-temporal Characteristics of Mutual Funds’Herd Behavior显示文摘Herd behavior in financial markets often leads to unjustified macroscopic phenomena.However,despite existing studies on modeling herd behavior,how it varies across individual agents and over time remains unclear.We show that herd behavior in mutual fund companies can be understood from the functional networks representing interactions inferred from investment similarities.Specifically,in this paper,the spatial characteristics of herd behavior stand for the topology relationships of observations in networks.We analyze the collective dynamics of mutual fund investment from 2003 to 2019 in China using the language of network science and show that herding behavior accompanies this industry's development but dwindles after the 2015 Chinese market crash.By integrating community detection analysis,we found an increased degree of coherence in the collective herding behavior of the system,even though the localization of herding behavior decreases for clusters of mutual fund companies when the systemic risk builds up.Further analysis showed that herding behavior impacts the payoff of individual fund companies differently across years.The spatial-temporal changes of herding behavior between mutual funds presented in this paper shed light on the debate of individual versus systemic risk and,thus,could interest regulators and investors. | Rong Guan Hongjia Chen Shan Lu | 2021 | Journal of Systems Science and Systems Engineering2021，30，6： | 0 |
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