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| 1 | Interaction between Rice stripe virus Disease- Specific Protein and Host PsbP Enhances Virus Symptoms显示文摘瑞斯条纹病毒(RSV ) 在许多东方亚洲国家在 Oryza sativa (米饭) 引起严重疾病。RSV 的疾病特定的蛋白质(SP ) 是非结构的蛋白质,它在米饭植物的 accumulationlevel 被显示决定 RSV 症状的严厉。这里,我们在米饭或 Nicotiana benthamiana 独自一个的 RSVSP 的那表情没生产可见症状的现在的证据。然而,在这二植物的 SP 的表示提高了 RSV- 或土豆病毒 X (PVX ) 导致了症状。通过酵母二混血儿的屏蔽, GST 下拉,和双分子的荧光互补试金,我们证明 RSV SP 与 PsbP 交往了, 23-kDa 演变氧的复杂蛋白质,在米饭和 N。benthamiana。而且,我们的调查证明在两植物的 PsbP 表示的 silencing 增加了疾病症状 severityand 病毒累积。共焦的显微镜学使用 N。benthamiana 原物证明 PsbP 在野类型的 N 在叶绿体主要积累了。benthamiana 房间。面对 RSV SP,大多数 PsbP 被招募进 assayed 房间的细胞质。另外, accumulationof SP 在 RSV 感染期间导致了叶绿体结构和功能的改变。我们的调查结果使位于 RSV 疾病症状 development.Key 词下面的 molecularmechanism 清楚些: | Lingfang Kong Jianxiang Wu Lina Lu Yi Xu Xueping Zhou | 2014 | Molecular Plant2014，7，4： | 13 |
| 2 | Mechanistic studies of the transport of peimine in the Caco-2 cell model显示文摘Fritillaria thunbergii Miq. has been widely used in traditional Chinese medicine for its expectorant, antitussive, antiinflammatory and analgesic properties. Moreover, modern pharmacological studies have demonstrated that F. thunbergii Miq. has efficacy in the treatment of leukemia and cancers of the liver and cervix. Although the alkaloid, peimine, is largely responsible for these pharmacological effects, it has very low oral bioavailability. The aim of this study was to investigate the intestinal absorption of peimine in Caco-2 cell monolayers. Having demonstrated that peimine is non-toxic to Caco-2 cells at concentrations o200 μmol/L, the effect of peimine concentration, p H, temperature, efflux transport protein inhibitors and EDTA-Na_2 on peimine transport were studied. The results show that peimine transport is concentration-dependent; that at p H 6.0 and 7.4, the P_(app(AP-BL))of peimine is not significantly different but the Papp(BL-AP)) is; that both Papp(AP-BL)and P_(app(BL-AP))at 4 1C are significantly higher than their corresponding values at 37 1C; that the P-glycoprotein(P-gp) inhibitors, verapamil and cyclosporin A, increase absorption of peimine; and that EDTA-Na2 has no discernible effect. In summary,the results demonstrate that the intestinal absorption of peimine across Caco-2 cell monolayers involves active transport and that peimine is a substrate of P-gp. | Lihua Chen Xueping Lu Xinli Liang Dandan Hong Zhiyu Guan Yongmei Guan Weifeng Zhu | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 8 |
| 3 | Comparative transcriptome analysis reveals defense responses against soft rot in Chinese cabbage显示文摘Pectobacterium carotovorum ssp.carotovorum(Pcc)is a necrotrophic bacterial species that causes soft rot disease in Chinese cabbage.In this study,plants harboring the resistant mutant sr gene,which confers resistance against Pcc,were screened from an 800 M2 population mutated by ethyl methane sulfonate(EMS)and scored in vitro and in vivo for lesion size.The transcript profiles showed~512 differentially expressed genes(DEGs)between sr and WT plants occurring between 6 and 12 h postinoculation(hpi),which corresponded to the important defense regulation period(resistance)to Pcc in Chinese cabbage.The downstream defense genes(CPK,CML,RBOH MPK3,and MPK4)of pathogen pattern-triggered immunity(PTI)were strongly activated during infection at 12 hpi in resistant mutant sr;PTI appears to be central to plant defense against Pcc via recognition by three putative pattern recognition receptors(PRRs;BrLYM1-BrCERK1,BrBKK1/SERK4-PEPR1,BrWAKs).Pcc triggered the upregulation of the jasmonic acid(JA)and ethylene(ET)biosynthesis genes in mutant sr,but auxins and other hormones may have affected some negative signals.Endogenous hormones(auxins,JAs,and SA),as well as exogenous auxins(MEJA and BTH),were also verified as functioning in the immune system.Concurrently,the expression of glucosinolate and lignin biosynthesis genes was increased at 12 hpi in resistant mutant sr,and the accumulation of glucosinolate and lignin also indicated that these genes have a functional defensive role against Pcc.Our study provides valuable information and elucidates the resistance mechanism of Chinese cabbage against Pcc infection. | Mengyang Liu Fang Wu Shan Wang Yin Lu Xueping Chen Yanhua Wang Aixia Gu Jianjun Zhao Shuxing Shen | 2019 | Horticulture Research2019，6，1： | 2 |
| 4 | Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies显示文摘Circular RNAs(circ RNAs),a class of endogenous RNA molecules,are produced by alternative splicing of precursor RNA and are covalently linked at the 5′and 3′ends.Recent studies have revealed that dysregulated circ RNAs are closely related to the occurrence and progression of gastrointestinal malignancies.Accumulating evidence indicates that circ RNAs,including circ PVT1,circ LARP4,circ-SFMBT2,cir-ITCH,circ RNA_100782,circ_100395,circ-DONSON,hsa_circ_0001368,circ NRIP1,circ FAT1(e2),circ CCDC66,circ SMARCA5,circ-ZNF652,and circ_0030235 play important roles in the proliferation,differentiation,invasion,and metastasis of cancer cells through a variety of mechanisms,such as acting as micro RNA sponges,interacting with RNA-binding proteins,regulating gene transcription and alternative splicing,and being translated into proteins.With the characteristics of high abundance,high stability,extensive functions,and certain tissue-,time-and diseasespecific expressions,circ RNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies. | Xueping Tao Yongfu Shao Jianing Yan Liyang Yang Qihua Ye Qingling Wang Rongdan Lu Junming Guo | 2021 | Cancer Biology & Medicine2021，18，2： | 2 |
| 5 | Devonian integrative stratigraphy and timescale of China显示文摘The Global Boundary Stratotype Sections and Points(GSSPs) for the bases of all seven international Devonian stages have been formally defined and ratified by IUGS till 1996, and nowadays, the main tasks for Devonian stratigraphers include further subdivision of these standard stages, strictly constrained absolute ages for the boundaries, and precise neritic-pelagic and marine-terrestrial correlations using multidisciplinary stratigraphy methods. Establishment of high-resolution Devonian integrative stratigraphy framework and timescale of China would play an important role in improving regional and international correlation, facilitating the recognition of important stratigraphic levels in different paleogeographic settings, and understanding the evolution pattern of biota, paleoclimate and paleoenvironment during this critical interval. Based on well-studied bio-and chronostratigraphy of Devonian in South China and adjacent areas, in combination with recent achievements in carbon isotope stratigraphy, event stratigraphy and radioactive isotope ages, this paper briefly summarize the research history and current status of Devonian chronostratigraphy of China, and for the first time introduce Devonian integrative stratigraphy framework of China.Up to date, few studies have been conducted on the astronomical cyclostratigraphy and high-resolution radioactive isotope dating in Devonian of China, which should be our main focuses in the near future. | Wenkun QIE Xueping MA Honghe XU Li QIAO Kun LIANG Wen GUO Junjun SONG Bo CHEN Jianfeng LU | 2019 | Science China Earth Sciences2019，62，1： | 2 |
| 6 | Low-carbon emission/economic power dispatch using the multi- objective bacterial colony chemotaxis optimization algorithm considering carbon capture power plant显示文摘 | Lu Zhigang Feng Tao Li Xueping | 2013 | Electrical Power and Energy Systems2013，53，4： | 1 |
| 7 | Better prognostic determination of cT3 rectal cancer through measurement of distance to mesorectal fascia:A multicenter study显示文摘Objective:To forward the magnetic resonance imaging(MRI)based distance between the deepest tumor invasion and mesorectal fascia(DMRF),and to explore its prognosis differentiation value in cT3 stage rectal cancer with comparison of cT3 substage.Methods:This was a retrospective,multicenter cohort study including cT3 rectal cancer patients undergoing neoadjuvant chemoradiotherapy followed by radical surgery from January 2013 to September 2014.DMRF and cT3 substage were evaluated from baseline MRI.The cutoff of DMRF was determined by disease progression.Multivariate cox regression was used to test the prognostic values of baseline variables.Results:A total of 804 patients were included,of which 226(28.1%)developed progression.A DMRF cutoff of7 mm was chosen.DMRF category,the clock position of the deepest position of tumor invasion(CDTI)and extramural venous invasion(EMVI)were independent predictors for disease progression,and hazard ratios(HRs)were 0.26[95%confidence interval(95%CI),0.13-0.56],1.88(95%CI,1.33-2.65)and 1.57(95%CI,1.13-2.18),respectively.cT3 substage was not a predictor for disease progression.Conclusions:The measurement of DMRF value on baseline MRI can better distinguish cT3 rectal cancer prognosis rather than cT3 substage,and was recommended in clinical evaluation. | Xiaoyan Zhang Qiaoyuan Lu Xiangjie Guo Wuteng Cao Hongmei Zhang Tao Yu Xiaoting Li Zhen Guan Xueping Li Ruijia Sun Yingshi Sun | 2021 | Chinese Journal of Cancer Research2021，33，5： | 1 |
| 8 | Low-carbon emission economic power dispatch using the multi-objective bacterial colony chemotaxis optimization algorithm considering carbon capture power plant显示文摘 | Lu Zhigang Feng Tao Li Xueping | 2013 | Electrical Power and Energy Systems2013，，53： | 1 |
| 9 | Shell-side thermal- hydraulic performances of multilayer spiral-wound heat exchangers under different wall thermal boundary conditions显示文摘 | LU Xing DU Xueping ZENG Min et at | 2014 | Applied Thermal Engineering2014，70，2： | 1 |
| 10 | Selfassembled three-dimensional graphene-based materials for dye adsorption and catalysis显示文摘 | Zhang Xueping Liu Dong Yang Lu | 2015 | Journal of Materials Chemistry A2015，3，10： | 1 |
| 11 | Low-carbon emis- sion economic power dispatch using the multi-objective bacterial colony chemotaxis optimization algorithm consid- ering carbon capture power plant 显示文摘 | Lu Zhigang Feng Tao Li Xueping | 2013 | Electrical Power and Energy Systems2013，53，1： | 1 |
| 12 | Recent advances in synthesis of organosilicons via radical strategies显示文摘Organosilicon compounds play an important role in the fields of materials science,pharmacy,and organic synthesis.The development of effective approaches for the preparation of these compounds have also become a research focus in organic synthesis.In recent years,free radical synthesis of organosilicons has been vigorously developed,which generally has the advantages of milder synthesis conditions,higher yields and selectivity,and free of precious metal catalysts compared with traditional strategies.This article reviews research progresses in the synthesis of organosilico n compounds by free radical pathways since 2016.In most cases,the radical silylation is achieved based on the reaction of silyl radicals,which are triggered by four routes including peroxide,transition-metal-induced peroxide decomposition,alkali,photocatalysis.The alkyl radicals can also initiate the radical silylation for the generation of C(sp^(3))—Si bonds. | Xueping Zhang Jingkun Fang Chun Cai Guoping Lu | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 13 | Shell-side thermal-hydraulic performances of multilayer spiral-wound heat exchangers under different wall thermal boundary conditions 显示文摘 | LU Xing DU Xueping ZENG Min | 2014 | Applied Thermal Engineering2014，70，2： | 1 |
| 14 | Deep Feature Fusion Model for Sentence Semantic Matching显示文摘Sentence semantic matching(SSM)is a fundamental research in solving natural language processing tasks such as question answering and machine translation.The latest SSM research benefits from deep learning techniques by incorporating attention mechanism to semantically match given sentences.However,how to fully capture the semantic context without losing significant features for sentence encoding is still a challenge.To address this challenge,we propose a deep feature fusion model and integrate it into the most popular deep learning architecture for sentence matching task.The integrated architecture mainly consists of embedding layer,deep feature fusion layer,matching layer and prediction layer.In addition,we also compare the commonly used loss function,and propose a novel hybrid loss function integrating MSE and cross entropy together,considering confidence interval and threshold setting to preserve the indistinguishable instances in training process.To evaluate our model performance,we experiment on two real world public data sets:LCQMC and Quora.The experiment results demonstrate that our model outperforms the most existing advanced deep learning models for sentence matching,benefited from our enhanced loss function and deep feature fusion model for capturing semantic context. | Xu Zhang Wenpeng Lu Fangfang Li Xueping Peng Ruoyu Zhang | 2019 | Computers, Materials & Continua2019，，8： | 1 |
| 15 | Lignin-derived Zn single atom/N-codoped porous carbon forα-alkylation of aromatic ketones with alcohols via borrowing hydrogen strategy显示文摘A green and scalable strategy has been developed for the synthesis of lignin-derived Zn single atom/N-codoped porous carbon(LCN@Zn-SAC)containing similar ZnNx sites with carbonic anhydrases.This catalyst exhibits superior activity on theα-alkylation of ketones with alcohols via borrowing hydrogen strategy(TON up to 15 h^(−1))than most of previously reported works.The dehydrogenation of benzyl alcohol is the rate-determining step based on kinetic experiment results.According to experimental and theoretical calculation results,Zn electron density is inversely proportional to reaction energy barriers,because Zn sites with less positive charge(ZnN_(4) and ZnN_(3)C)in Zn-SACs display better borrowing hydrogen ability than other Zn sites.Furthermore,this catalyst can be recycled by simple centrifugation,which can be reused at least 8 runs with no obvious lose in activity.To the best of our knowledge,this is the first example of non-noble metal-SAC-catalyzedα-alkylation via borrowing hydrogen strategy. | Xueping Zhang Guo-Ping Lu Kun Wang Yamei Lin Pengcheng Wang Wenbin Yi | 2022 | Nano Research2022，15，3： | 1 |
| 16 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 17 | Shell-side thermal-hydraulic performances of multilayer spiral-wound heat exchangers under different wall thermal boundary conditions显示文摘 | Xing Lu Xueping Du Min Zeng Sen Zhang Qiuwang Wang | 2014 | Applied Thermal Engineering2014，，： | 1 |
| 18 | The growing hydro-electric power equipment manufacturing engineering of China显示文摘General situationChina is rich in water power resources.The theoretical valueamounts to 6.76x105 MW,among which attainable exploitable waterpower resources is 3.78×10~5 MW.The comprehensive utilization ofwater power in China is an age-old tradition.The ancient agriculturalmechanical devices,such as hydraulic pestle mills in South Chinaand huge irrigation wheels erected along the banks of Yellow River inGansu Province remain unchanged as legacies of history.But theutilization of her rich water power resources for electric energy gen-eration had not come true until last tens of years.Before the founding of the People’s Republic of China,therewere only 50 odd small hydro electric power stations,with total in- | Lu Xueping Scien-technical Information and Research Institute,Ministry of Machinery and Electronics Industry of P.R.China | 1991 | Electricity1991，，2： | 0 |
| 19 | CRISPR/Sc^(++)-mediated genome editing in rice显示文摘Streptococcus canis Cas9(ScCas9)is an RNAguided endonuclease with NNG protospacer adjacent motif(PAM)specificity whose genomeediting activity in rice is locus-dependent.Here we investigated the performance of a ScCas9 variant named Sc^(++)at different NNG PAM sites in the rice genome;Sc^(++)harbors a T1227K mutation and the substitution of a positively charged loop(residues 367-376).Sc^(++)nuclease achieved broader genome editing compared to the original ScCas9,and its nickase improved targeted base editing in transgenic rice plants.Using the high-efficiency adenine base editor rBE73b,we generated many new OsGS1 alleles suitable for screening of rice germplasm for potential herbicide resistance in the future.The CRISPR/Sc^(++)system expands the genomeediting toolkit for rice. | Guigen Ma Yongjie Kuang Zhenwan Lu Xueqi Li Ziyan Xu Bin Ren Xueping Zhou Huanbin Zhou | 2021 | Journal of Integrative Plant Biology2021，63，9： | 0 |
| 20 | A Study on Remediation Technologies for Cadmium Contamination in Greenhouse Vegetable Fields显示文摘Based on the literature and experimental results, three kinds of amendments, namely, rice biochar, hydroxyapatite and potassium dihydrogen phosphate(KH2PO4), and deeper ploughing were selected to evaluate the field application effect of soil amendments and agronomic measures on the remediation of Cd contamination in greenhouses. Cd-contaminated greenhouse screening was conducted from 2015 to 2017. In September 2017, comparative tests of eight treatments were performed in September 2017, and a selective test was performed in September 2018. The results of the screening of contaminated areas indicated that the distributions of over-standard sites and Cd content were significantly different. Greenhouse No. 4, in which the highest over-standard rate was 83.33% and the average content of Cd in soil was 0.535 mg/kg, was used as a comparative test experimental site for eight treatments. Greenhouse No. 1 was selected as the optimum test greenhouse for selective testing, with three plots having average Cd concentrations of 0.530, 0.568 and 0.792 mg/kg. The 8 months following comparative treatment showed that the content of available Cd following the treatment of rice biochar+hydroxyapatite+deeper ploughing(treatment T6) was reduced by 32.55% and 24.96% compared with the CK(the control) and 2 months following treatment, respectively. The content of available Cd using rice biochar+KH2PO4+deeper ploughing(treatment T7) treatment decreased by 47.88% and 31.00% compared with the CK and 2 months following treatment. The selective test results showed that in rice biochar+hydroxyapatite+deeper ploughing: the total Cd content of decreased from 0.489 to 0.372 mg/kg(23.86% lower), compared with the CK, and the mean content of available Cd decreased by 10.71% after 8 months, which was the lowest available Cd measured(0.133 mg/kg). In addition, the bean plant Cd content, bioconcentration factor(BCF) and translocation coefficient(TF) decreased by 15.86%, 23.68% and 25.77%, respectively. Rice biochar+hydroxyapatite+deeper ploughing is a favoured technology for the remediation of Cd-contaminated protected vegetable fields. | Xueping SHI Huiwei ZHAO Yiming LIU Wei LIU Chenghai ZHENG Chuan LU Lifang ZHAI | 2021 | Agricultural Biotechnology2021，10，1： | 0 |
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