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| 1 | Performance of melon hybrids derived from parents of diverse geographic Origins显示文摘 | Feishi Luan Yunyan Sheng Yuhan Wang Jack E. Staub | 2010 | Euphytica2010，，1： | 1 |
| 2 | Genetic Diversity within Chinese Watermelon Ecotypes Compared with Germplasm from Other Countries显示文摘 | Sheng Yunyan Luan Feishi Zhang Faxing | 2012 | Journal of the A- merican Society for Horticultural Science2012，137，3： | 1 |
| 3 | Effect of grapeseed proanthocyanidins on tumor vasculogenic mimicry in humantriple-negative breast cancer cells显示文摘 | LUAN Yunyan LIU Zimin ZHONG Jinyi | 2015 | Asian Pacific Journal of CancerPrevention2015，16，2： | 1 |
| 4 | 葡萄原花青素对H22肝癌移植瘤生长及血管生成的影响(英文)显示文摘Objective: The aim of this study was to investigate the effect of grape proanthocyanidins(GPC) on the growth and angiogenesis of hepatocellular carcinoma H22 cells xenograft in mice. Methods: The xenograft model was established using injected subcutaneously H22 cells into the right axilla of the mice. Each group was treated with different doses of GPC and Endostar. All these treatments were maintained for 10 days, and mice were sacrificed. The xenograft tumors in mice were measured. The proliferation activity level of H22 cells was determined by MTT assay, and the levels of vascular endothelial growth factor(VEGF) protein were examined by immunohistochemistry. Results: When treated with 50, 100 and 200 mg/kg of GPC and Endostar, the tumor inhibition rates were 13.17%, 23.37%, 36.15% and 14.71%, respectively. The tumor weight of xenograft was significantly lighter in high GPC group than the control group(P < 0.05). The ODs in GPC groups were 0.835, 0.666 and 0.519, respectively. The absorbances in middle and high GPC groups were statistically significant, compared with control group(P < 0.01). Immunohistochemical technique showed the expression of VEGF of the GPC groups was downregulated significantly compared with the control group(P < 0.01). Conclusion: GPC can inhibit the growth of hepatocellular carcinoma H22 cell xenograft in mice. The inhibition of angiogenesis by the down-regulation of VEGF expression may play a key role in the anti-neoplastic effect of GPC. | Lili Feng Jinyi Zhong Bingxia Liu Libin Sun Hongsheng Yu Yong Qu Yunyan Luan | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，2： | 0 |
| 5 | 葡萄原花青素对H22肝癌移植瘤血管生成拟态的作用及其机制研究(英文)显示文摘Objective: As a novel blood supply pattern, vasculogenic mimicry(VM) has attracted increasingly attention in recent years, which may partly compensate for the absence of feeding and facilitate tumor perfusion. However, anti-angiogenic drugs have little effect on VM. The grape seed proanthocyanidins(GSPs), a kind of promising bioactive phytochemical, has shown anti-carcinogenesis and anti-angiogenic in several tumor models. However, GSPs regulation of VM and its possible mechanisms in a H22 hepatoma carcinoma model remain not clear. The aim of this study was to examine the effects of GSPs on proliferation and VM in a H22 hepatoma carcinoma model and to investigate the underlying mechanism. Methods: Seventy-five mice were divided into the control group and experimental groups treated with different concentration of GSPs. CD34-PAS dual staining was employed to identify the VM structure. The immunohistochemical staining for investigating the expression of VEGF, Eph A2 and MMP-2 protein was performed. Results: Treatment of the H22 model with Endostar(4 mg/kg), 50, 100, 200 mg/kg of the GSPs resulted in 6.87%, 17.81%, 27.43%, 53.52% inhibition in tumor growth, respectively. The mean weight of tumors were significantly lower in GSPs(100 mg/kg) and GSPs(200 mg/kg) groups than in the control group(all P < 0.01). Similarly, compared with the control group, the number of VM channels were significantly reduced in GSPs(100 mg/kg) and GSPs(200 mg/kg) groups(all P < 0.01). Immunohistochemistry showed significant decreases in the expression levels of VEGF, Eph A2 and MMP-2 protein in GSPs(100 mg/kg) and GSPs(200 mg/kg) groups when compared with control group(all P < 0.001). Conclusion: This is the first report providing evidence that GSPs inhibit the VM structure by regulation of the VEGF/Eph A2/MMPs signaling pathway. Therefore, we concluded that GSPs has the potential of being a clinical anti-VM inhibitor. | Yunyan Luan Hongwei Xue Lijian Zhang Ruyong Yao Hongsheng Yu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，12： | 0 |
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