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| 1 | 在心血管的疾病的先进 glycation 结束产品的角色显示文摘 Advanced glycation end products(AGEs) are produced through the non enzymatic glycation and oxidation of proteins,lipids and nucleic acids.Enhanced formation of AGEs occurs particularly in conditions associated with hyperglycaemia such as diabetes mellitus(DM).AGEs are believed to have a key role in the development and progression of cardiovascular disease in patients with DM through the modif ication of the structure,function and mechanical properties of tissues through crosslinking intracellular as well as extracellular matrix proteins and through modulating cellular processes through binding to cell surface receptors [receptor for AGEs(RAGE)].A number of studies have shown a correlation between serum AGE levels and the development and severity of heart failure(HF).Moreover,some studies have suggested that therapies targeted against AGEs may have therapeutic potential in patients with HF.The purpose of this review is to discuss the role of AGEs in cardiovascular disease and in particular in heart failure,focussing on both cellular mechanisms of action as well as highlighting how targeting AGEs may represent a novel therapeutic strategy in the treatment of HF. | Zeinab Hegab Stephen Gibbons Ludwig Neyses Mamas A Mamas | 2012 | World Journal of Cardiology2012，4，4： | 58 |
| 2 | 等轴球晶凝固多相体系内热溶质对流、补缩流及晶粒运动的数值模拟 Ⅰ.三相流模型显示文摘基于Eulerian-Eulerian方法和体积元平均技术,建立了模拟等轴球晶凝固过程的液、固、气三相流模型.液、固两相处理成相互分离、相互扩散的介质,气相与液、固两相只存在热量及动量的相互作用,三相(凝固前)作为自由流体共享一个统一的压力场.分别求解三相的质量、动量、溶质、热焓守恒方程;相间的热量交换和摩擦拖拽以及液/固界面上的溶质再分配和凝固潜热释放,通过定义对应守恒方程的源项和交换项而加以考虑;另外,单独求解一个晶粒密度守恒方程.晶粒的形核生长(相变) 也加以模型化并体现在对应的源项中,模型中所用的密度定义为溶质与温度的函数,因此可综合考虑热溶质对流、晶粒运动及凝固收缩所引起的补缩流动.凝固过程的体积收缩及补缩流动将体现在气/液自由表面的波动上. | 王同敏 姚山 张兴国 金俊泽 M Wu A Ludwig B Pustal A Bührig-Polaczek | 2006 | 金属学报2006，42，6： | 18 |
| 3 | 等轴球晶凝固多相体系内热溶质对流、补缩流及晶粒运动的数值模拟 Ⅱ.模型的应用显示文摘利用等轴球晶三相凝固模型模拟了A356铝合金半固态浆料冷却斜槽法制备过程,研究了晶粒密度、尺寸及固相分数的分布与工艺参数的关系.结果表明,在斜槽浇注处晶粒形核密度最大,在斜槽末端晶粒尺寸、固相分数最大,在铸型中这三者的最终分布大致均匀.适当降低浇注温度有助于提高斜槽上形核密度和固相分数及降低晶粒尺寸.此外,还模拟了热溶质对流及补缩流在Al-4%Cu(质量分数)合金等轴球晶凝固过程所起的作用,以及晶粒运动及补缩流对合金自由表面和宏观偏析形成的影响.结果表明,凝固初期热对流及补缩流为主导,凝固中期热溶质对流为主导,凝固后期补缩流为主导;晶粒运动受阻程度直接影响自由表面形状,补缩流考虑与否导致完全不同的宏观偏析图.实验测得晶粒尺寸与模拟结果分布较相似,但其绝对值存在较大差异. | 王同敏 李廷举 曹志强 金俊泽 T Grimmig A Bührig-Polaczek M Wu A Ludwig | 2006 | 金属学报2006，42，6： | 7 |
| 4 | Atrial fibrillation in heart failure: The sword of damocles revisited显示文摘Heart failure (HF) and atrial fibrillation (AF) frequently coexist and have emerged as major cardiovascular epidemics. There is growing evidence that AF is an independent prognostic marker in HF and affects patients with both reduced as well as preserved LV systolic function. There has been a general move in clinical practice from a rhythm control to a rate control strategy in HF patients with AF, although recent data suggests that rhythm control strategies may provide better outcomes in selected subgroups of HF patients. Furthermore, various therapeutic modalities including pace and ablate strategies with cardiac resynchronisation or radio-frequency ablation have become increasingly adopted, although their role in the management of AF in patients with HF remains uncertain. This article presents an overview of the multidimensional impact of AF in patients with HF. Relevant literature is highlighted and the effect of various therapeutic modalities on prognosis is discussed. Finally, while novel anticoagulants usher in a new era in thromboprophylaxis, research continues in avariety of new pathways including selective atrial anti-arrhythmic agents and genomic polymorphisms in AF with HF. | Muhammad A Khan Fozia Ahmed Ludwig Neyses Mamas A Mamas | 2013 | World Journal of Cardiology2013，5，7： | 4 |
| 5 | Neonatal colon perforation due to anorectal malformations: Can it be avoided?显示文摘Anorectal malformations (ARM) are common anomalies in neonates. Diagnostic and therapeutic delays in the management of ARM may lead to colonic perforation, and even death. Physical examination of the perineum is often sufficient to diagnose ARM in neonates. Notwithstanding, delayed diagnosis of ARM has become increasingly familiar to surgeons, as evidenced by the number of recent publications on this topic in the literature. In this commentary, we discuss spontaneous colonic perforation due to delayed diagnosis of ARM in neonates, and highlight the importance of early diagnosis in assuring good outcomes with surgical management. At this point, a thorough examination of the perineum during the initial newborn assessment is mandatory, particularly in those patients presenting with abdominal signs or symptoms. | Wei-Dong Tong Kirk A Ludwig | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 6 | Thermophysical properties necessary for advanced casting simulations 显示文摘 | Ludwig A | 2002 | International Journal of Themophysics2002，29，5： | 2 |
| 7 | The flavonoid phloretin suppresses stimulated expression of endothelialadhesion molecules and reduces activation of human platelets 显示文摘 | Tangl V Lorenz M Ludwig A | 2005 | The Journal of Nutrition2005，135，2： | 1 |
| 8 | Intima media thickness of the carotid arteries:early pointer to arteriosclerosis and therapeutic endpoint显示文摘 | LUDWIG M VON PETZINGER-KRUT HOFF A VON BUQUOY M | 2003 | Ultraschall Med2003，24，3： | 1 |
| 9 | Vegetation pat ehes and runoff-erosion as interacting ecohydrological proces ses in semi-arid landscape 显示文摘 | Ludwig J A Wilcox B P Breshears D D | 2005 | Ecology2005，86，2： | 1 |
| 10 | Plant sucrose-H+symporters mediate the transport of vitamin H显示文摘 | Ludwig A Stolz J Sauer N | 2000 | Plant J2000，24，4： | 1 |
| 11 | Laser in situ keratomileusis in human corneas:New organ culture model显示文摘 | May CA Priglinger SG Neubauer AS Alge CS Ludwig K Kampik A | 2004 | J Cataract Refract Surg2004，30，1： | 1 |
| 12 | Magnetic properties and microstructure of giant magnetostrictive TbFe/FeCo multilayers 显示文摘 | Quandt E Ludwig A | 1998 | Journal of Applied Physics1998，83，11： | 1 |
| 13 | Coat Color Variation at the Beginning of Horse Domestication 显示文摘 | LUDWIG A PRUVOST M REISSMANN M | 2009 | Science2009，324，： | 1 |
| 14 | In-Situ Observation of Coupled Growth Morphologies in Organic Peritectics显示文摘 | MogeritschJ P Ludwig A | 2011 | lOP Conf Series: Materials Science and Engineering2011，27，01： | 1 |
| 15 | Intesive All-type therspy without local radiotherapy provides 90% EFS for children with T-cell lymphoblastic lymphoma:a BFM Group report显示文摘 | Reiter A Schrappe M Ludwig WD | | 0，，02： | 1 |
| 16 | The potential of lipid and polymer-based drug delivery carriers for eradicating biofilm consortia on device-related nosocomial infections显示文摘 | Tamilvanan S Venkateshan N Ludwig A | 2008 | J Control Release2008，128，1： | 1 |
| 17 | Molecular genetic evidence of bactetial colonization of cholesterol gallastones 显示文摘 | Swidsinski A Ludwig W Pahlig H | 1995 | Gastroenterology1995，108，6： | 1 |
| 18 | Natriuretic peptides as markers of mild forms of left ventricular dysfunction effects of assays on diagnostic performance of markers显示文摘 | Hammerer-Lercher A Ludwig W Falkensammer G | 2004 | Clin Chem2004，50，： | 1 |
| 19 | Vegetation patches and runoff-erosion as interacting ecohydrological processes in semiarid landscapes 显示文摘 | Ludwig J A Wilcox B P Breshears D D | 2005 | Ecology2005，86，2： | 1 |
| 20 | Optimisation of carbomer viscous eye drops:an invitro experimental design approach using rheological techniques 显示文摘 | Ceulemans J Ludwig A | 2002 | European Journal of Pharmaceutics and Biopharmaceutics2002，54，1： | 1 |
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