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| 1 | Recent advances in andrology-related stem cell research显示文摘因为他们自我更新并且到的能力,干细胞为再生药保持大诺言区分进各种各样的房间类型。尽管胚胎的干细胞(二进制同步通信) 比成年干细胞有更大的区别潜力,前者在因为道德的担心和政府限制,到达临床的应用程序正在落后。骨头髓干细胞(BMSC ) 是学习最好的成年干细胞(ASC ) 并且有潜力治疗许多疾病,包括可勃起的机能障碍(编辑) 和男不孕。更最近发现的脂肪质的导出织物的干细胞(ADSC ) 与在区别和治疗学的潜力的骨头髓干细胞几乎相同,但是更容易、更安全获得,能在更大的数量被收获,并且有减少肥胖的联系利益。因此, ADSC 看起来是为未来的一种更好的选择临床的应用。我们以前证明了转换字符能在老鼠恢复神经原的编辑的可勃起的功能,并且我们现在有 ADSC 能那么也做的证据。我们也正在调查 ADSC 是否能区分进 Leydig, Sertoli 和男细菌房间。最终的目标是使用 ADSC 对待男不孕和睾丸激素缺乏。 | Ching-Shwun Lin Zhong-Cheng Xin Chun-Hua Deng Hongxiu Ning Guiting Lin Tom F. Lue | 2008 | Asian Journal of Andrology2008，10，2： | 18 |
| 2 | Comparison of the clinical accuracy of cervical (C2-C7) pedicle screw insertion assisted by fluoroscopy, computed tomography-based navigation, and intraoperative three-dimensional C-arm navigation显示文摘背景在小花梗之中的颈的脊骨和变化的复杂解剖减少精确性并且增加在这个区域与螺丝钉培植联系的神经与血管的复杂并发症的风险。在这研究,我们比较了精确性颈(C2-C7 ) 小花梗螺丝钉固定由 X 光检查荧光检查帮助了,计算断层摄影术(CT ) 基于航行,或 intraoperative 三维(3D )C 手臂 navigation.Methods 这未来的队研究在经历了颈的小花梗的 82 个连续病人被执行螺丝钉固定。螺丝钉插入的精确性被手术后的 CT 扫描与 3D 重建估计。螺丝钉插入的精确性是被估计:优秀(在小花梗以内完全拧紧) ;可接受(1 张公里螺丝钉外面小花梗外皮) ;145 全部的 .Results A 淫的穷人(1 张公里螺丝钉外面小花梗外皮) 在经历了 C 手臂荧光检查的 24 个病人被插入。这些, 96 个螺丝钉(66.2%) 是优秀的,(25.5%) 37 是可接受的,并且(8.3%) 12 是差的。159 个螺丝钉在基于 CT 的航行组在 29 个病人被插入。在这些之中,(88.7%) 141 是优秀的,(8.8%) 14 是可接受的,并且(2.5%) 4 是差的。140 个螺丝钉的一个总数在 intraoperative 3D C 手臂航行组,(90.7%) 127 是优秀的在 29 个病人被插入,并且(9.3%) 13 是可接受的。与螺丝钉插入联系的严重或永久的神经与血管的复杂并发症都没在基于 CT 的任何 patient.Conclusione 被观察, intraoperative 3D C 手臂航行是同样精确的,并且显著地是两个比为指导颈的小花梗的 C 手臂荧光检查精确的更多拧紧固定。他们能精确地用视觉 3D 图象指导螺丝钉放置的角度和深度。这二种技术为高风险的颈的小花梗螺丝钉固定因此更好。intraoperative 3D C 手臂航行的容易和便利建议它可以在未来代替虚拟荧光检查、基于 CT 的航行系统临床的应用程序。 | LIU Ya-jun TIAN Wei LIU Bo LI Qin HU Lin LI Zhi-yu YUAN Qiang LUE Yan-wei SUN Yu-zhen | 2010 | Chinese Medical Journal2010，，21： | 17 |
| 3 | 施万细胞在阴茎和外周神经再生中的作用显示文摘施万细胞(SCs)是外周神经系统中主要的胶质细胞。施万细胞最终发育为形成髓鞘的细胞和不形成髓鞘的细胞,前者包绕直径较大的神经,后者则包绕直径较小的神经。他们在神经损伤后的再生中发挥重要作用,包括海绵体神经损伤导致的勃起功能障碍(ED)。尽管前列腺癌根治术手术技术有所提高,但是仍有相当一部分患者术后出现ED。这是由于术中牵拉损伤或局部炎症反应改变了自主神经的微环境,最终导致终末器官-阴茎的病理生理改变。该综述目的是总结现有的如下方面相关文献:(1)外周神经特别是阴茎神经中施万细胞的起源和发育;(2)外周神经特别是阴茎神经损伤后的Wallerian变性和施万细胞的可塑性;(3)施万细胞如何通过分泌神经生长因子促进神经再生;(4)以施万细胞作为治疗靶点促进神经再生的技术。我们搜索了Pubmed,发现了为数众多的与上述主题相关的动物实验和人体研究,这提示施万细胞有望成为神经源性ED治疗的新靶点。 | Lin Wang Melissa T Sanford Zhongcheng Xin Guiting Lin Tom F Lue | 2015 | Asian Journal of Andrology2015，17，5： | 7 |
| 4 | 阴茎勃起神经再生模型和机制的研究显示文摘探明神经性勃起功能障碍(NED)的分子生物学机制以期对该类疾病进行神经调控干预,是男科学研究的当务之急。本文回顾了急性神经损伤、前列腺癌、糖尿病和帕金森病所致的NED的研究进展。通过利用大鼠阴茎勃起神经的盆腔大神经节(MPG),在体外构建一个三维培养体系来研究各种生长因子和细胞信号通路对神经再生的影响。体外结果表明脑源性神经生长因子(BDNF)通过JAK/STAT信号通路可显著促进NED的恢复,并在体内证实了该效应。因此,通过调控JAK/STAT信号通路来达到神经调控干预措施预防治疗神经性勃起功能障碍成为可能。 | 林桂亭 Tom F Lue Ching-Shwun Lin | 2007 | 中华男科学杂志2007，13，12： | 7 |
| 5 | Mechanism of local scour around submarine pipelines based on numerical simulation of turbulence model显示文摘The mechanism of local scour around submarine pipelines is studied numerically based on a renormalized group (RNG) turbulence model. To validate the numerical model, the equilibrium profiles of local scour for two cases are simulated and compared with the experimental data. It shows that the RNG turbulence model can give an appropriate prediction for the configuration of equilibrium scour hole, and it is applicable to this situation. The local scour mechanism around submarine pipelines including the flow structure, shear stress distribution and pressure field is then analyzed and compared with experiments. For further comparison and validation, especially for the flow structure, a numerical calculation employing the large eddy simulation (LES) is also conducted. The numerical results of RNG demonstrate that the critical factor governing the equilibrium profile is the seabed shear stress distribution in the case of bed load sediment transport, and the two-equation RNG turbulence model coupled with the law of wall is capable of giving a satisfying estimation for the bed shear stress. Moreover, the piping phenomena due to the great difference of pressure between the upstream and downstream parts of pipelines and the vortex structure around submarine pipelines are also simulated successfully, which are believed to be the important factor that lead to the onset of local scour. | LUE Lin LI Yucheng CHEN Bing | 2006 | Acta Oceanologica Sinica2006，25，2： | 5 |
| 6 | Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury显示文摘在细胞死亡的生长因素,神经发展,和预防的神经生物学的进展为多孔的神经( CN )为保护、再生的 neuromodulatory 策略的发展导致了提高的临床的兴趣,当为前列腺癌症和另外的骨盆的恶意的治疗经常导致神经元损坏和性功能的削弱的损失。氮的氧化物在平滑肌的阴茎海绵体原因松驰以内免除了这些神经的轴索终板,开始象贡献维持的肿大一样的阴茎勃起的 haemodynamic 变化;CN 功能的损失在骨盆的外科以后为可勃起的机能障碍(编辑) 的开发主要负责并且为潜在的 neuroprotective 或再生策略用作主要目标。从为精选 neuromodulatory 途径的现出症状之前的潜的研究的证据被考察,包括 neurotrophins,神经胶质房间导出线的神经营养的因素(GDNF ) ,骨头 morphogenic 蛋白质, immunophilin ligands, erythropoetin (EPO ) ,和干细胞。 | Anthony J. Bella Guiting Lin Ilias Cagiannos Tom F. Lue | 2008 | Asian Journal of Andrology2008，10，1： | 5 |
| 7 | Penile prosthesis implantation in Chinese patients wit severe erectile dysfunction: 10-year experience显示文摘我们回顾地与严重可勃起的机能障碍(SED ) 在中国病人评估了阴茎修复术培植(PPI ) 的临床的结果。从 2000 年 7 月到 2011 年 12 月, 224 个病人(吝啬的年龄:35.9 ± 11.8 年,变化:20-75 年) 在我们的中心根据标准 PPI 过程由富有经验的外科医生与 SED 经历了 PPI。韧性的修复术(AMS 650 ) 在 45 种情况中被植入(20.1 %) ,并且三片的可膨胀的修复术(AMS 700 CXM 或 AMS 700 CXR ) 在 179 种情况中被植入(79.9 %) 。包括手术后的复杂并发症,临床的功效和夫妇满足,外科的结果被评估在上比手术后地使用医药记录抽象的 6 个月, IIEF-5,生活(QoL ) 的质量分数,和病人 / 搭挡的性满足分数由 Bhojwani 等求婚了。为学习合格的 224 个病人, 201 使遭到(89.7 %) 完成的后续。所有能与吝啬的手术后的 IIEF-5 病人执行性交柱子 PPI, QoL 分数是 20.02 ± 2.32 和 5.28 ± 0.76,分别地它显著地与外科手术前的分数相比被改进(6.29 ± 1.5 和 2.13 ± 0.84, P< 0.01 ) 。201 个人,机械失灵发生在四种情况中(2.0 %) 并且三个盒子被重新植入新设备,和二个盒子(1.0 %) 开发了阴茎的温和弯曲。有感染的阴囊的侵蚀与糖尿病 mellitus 发生在一种情况中(0.5 %) 并且植入的 AMS 的要求的完全的移动 700 CXM。令人满意的性交被 178 个人两次至少每月报导(88.6 %) ,并且对 PPI 外科的全面满足被 89.0 % 报导;人和 82.5 %搭挡。在三片的可膨胀的修复术组的耐心的满足比在韧性的修复术组高(P< 0.05 ) 。然而,在 prostheses 的类型之间,满足没在搭挡调查不同。PPI 是一种安全、有效的治疗选择因为有 SED 和富有经验的外科医生的中国病人根据标准 PPI 执行 PPI 过程能减少 PPI 的手术后的复杂并发症并且能改进耐心的满足比率和 QoL。 | Wei-Dong Song Yi-Ming Yuan Wan-Shou Cui Alex K Wu Yi-Chen Zhu Jing Liu Lin Wang Guang-Yi Ba Jing Peng Zhi-Chao Zhang Bing Gao Ying-Lu Guo Tom F Lue Zhong-Cheng Xin | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 8 | Low-intensity pulsed ultrasound for regenerating peripheral nerves:potential for penile nerve显示文摘Peripheral nerve damage,such as that found after surgery or trauma,is a substantial clinical challenge.Much research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after injury.In recent years,low-intensity pulsed ultrasound(LIPUS)has been studied as a potential method of stimulating peripheral nerve regeneration.In this review,the physiology of peripheral nerve regeneration is reviewed,and the experiments employing LIPUS to improve peripheral nerve regeneration are discussed.Application of LIPUS following nerve surgery may promote nerve regeneration and improve functional outcomes through a variety of proposed mechanisms.These include an increase of neurotrophic factors,Schwann cell(SC)activation,cellular signaling activations,and induction of mitosis.We searched PubMed for articles related to these topics in both in vitro and in vivo animal research models.We found numerous studies,suggesting that LIPUS following nerve surgery promotes nerve regeneration and improves functional outcomes.Based on these findings,LIPUS could be a novel and valuable treatment for nerve injury-induced erectile dysfunction. | Dong-Yi Peng Amanda B Reed-Maldonado Gui-Ting Lin Shu-Jie Xia Tom F Lue | 2020 | Asian Journal of Andrology2020，22，4： | 3 |
| 9 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 10 | Growth factor therapy and neuronal nitric oxide synthase显示文摘 | Lin CS Lue TF | 2004 | Int J Impot Res2004，161，： | 1 |
| 11 | Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells显示文摘 | Ning H Lin G Lue TF | 2006 | Differentiation2006，74，9： | 1 |
| 12 | Transdifferentiation of adipose-derived stem cells into hepatocytes:a new approach显示文摘 | Lue J Lin G Ning H | 2010 | Liver Int2010，30，6： | 1 |
| 13 | Growth factor therapy and neuronal nitric oxide synthase显示文摘 | Lin CS Lue TF | 2004 | Int J Impot Res2004，16，1： | 1 |
| 14 | Dynamic change of procalcitonin, rather than concentration itself,is predictive of survival in septic shock patients when beyond 10 ng/mL显示文摘 | Guan J Lin Z Lue H | 2011 | Shock2011，36，6： | 1 |
| 15 | Stem cell therapy for stress urinary incontinence : a critical review 显示文摘 | Lin CS Lue TF | 2012 | Stem Cells Dev2012，21，6： | 1 |
| 16 | Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells显示文摘 | Ning H Lin G Lue TF | 2006 | Differentia- tion2006，74，910： | 1 |
| 17 | Isolation of two isoforms of phosphodiesterase 5 from rat penis显示文摘 | Lin CS Lin G Lue TF | 2003 | Int J Impot Res2003，15，2： | 1 |
| 18 | Allogeneic and xenogeneic transplanta- tion of adipose - derived stem cells inimmunocompetent recipients without immunosuppressants 显示文摘 | Lin CS Lin G Lue TF | 2012 | Stem Ceils Dev2012，21，15： | 1 |
| 19 | Investigation on Slenderness Ratios of Built-Up Compression Members显示文摘 | Liu Juiling Dung M Lue Lin Ching H | 2009 | Journal of Constructional Steel Research2009，，： | 1 |
| 20 | A secure nonrepudiable threshold proxy signature scheme with known signers显示文摘 | HWANG MS LIN IC LUE JL | 2000 | Informatica2000，11，2： | 1 |
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