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| 1 | Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens显示文摘AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group. | Marcos Eduardo Lera dos Santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz Thiago Ferreira de Souza Fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai | 2013 | World Journal of Gastroenterology2013，19，22： | 16 |
| 2 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone - re- lated peptide gene显示文摘 | KARAPLIS A C LUZ A GLOWACKI J | 1994 | Genes Dev1994，8，3： | 1 |
| 4 | Embolism using 16-slice multi-detector row CT: evaluation of different imaging reconstruction parameters显示文摘 | Heuschmid M Mann C Luz O | 2006 | J Comput Assist Tomogr2006，30，1： | 1 |
| 5 | Risk factors for osteoporosis and fractures in postmenopausal women between 50 and 65 years of age in a primary care setting in Spain : a questionnaire 显示文摘 | Luz Rentero M Carbonell C Casillas M | 2008 | Open Rheumatol J2008，2，1： | 1 |
| 6 | Distribution of polycyclic aromatic hydrocarbons in marine sediments and their potential toxic effects显示文摘 | Froehner S Maceno M Luz E C D | 2010 | Environmental Monitoring and Assessment2010，168，14： | 1 |
| 7 | A new glass-forming ability criterion for bulk metallic glasses显示文摘 | LIU C T | 2002 | Acta Materialia2002，50，13： | 1 |
| 8 | Detection of pulmonary embolism using 16-slice muhidetector-row computed tomography: evaluation of different image reconstruction parameters 显示文摘 | HEUSCHMID M o MANN C LUZ O | 2006 | J Comput Assist Tomogr2006，30，1： | 1 |
| 9 | Flavonoids, flavonolignans and a phenylpropanoid from Onopordon corymbosum 显示文摘 | LUZ C M GARCIA B PEDRO J R | 1990 | Phytochemistry1990，9，2： | 1 |
| 10 | Comparativeoocyte morphology and fecundity of five characid species from S5o Francisco River basin, Brazil显示文摘 | Melo R M C Ferreira C M Luz R K | 2011 | J Appl Ichthyol2011，27，6： | 1 |
| 11 | Hot elastic modulus of Al2O3-Si C-Si O2-C castables显示文摘 | Luz A P Huger M Pandolfelli V C | 2011 | Ceramics International2011，37，7： | 1 |
| 12 | Cu-and Fe-ZSM-5 as catalysts for phenol hydroxylation显示文摘 | Aida Luz Villa César Augusto Caro Consuelo Montes de Correa | 2005 | Journal of Molecular Catalysis A:Chemical2005，228，12： | 1 |
| 13 | Psychoneurodendocrinecorrelates of lymphocyte subsets during healthy ageing 显示文摘 | Collaziol D Luz C Domelles F | 2004 | MechAgeing Dev2004，125，： | 1 |
| 14 | Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene显示文摘 | Karaplis A C Luz A Glowacki J | 1994 | Genes Dev1994，8，3： | 1 |
| 15 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 16 | Psychoneurodendocrine correlates of lymphocyte subsets during healthy ageing 显示文摘 | COLLAZIOL D LUZ C DORNELLES F | 2004 | Mech Ageing Dev2004，125，3： | 1 |
| 17 | Struc-tural characterization of coagulant Moringa oera Lectin and its effect on hemostatic param- eters显示文摘 | Luz L A Silva M C Ferreira R S | 2013 | Int J Biol Macromol2013，58，： | 1 |
| 18 | A hybrid recommendation approach for a tourism system 显示文摘 | Lucas J P Luz N Moreno M N Anacleto R Figueiredo A A Martins C ( 2013 ) | 2013 | Expert Systems with Applications2013，40，9： | 1 |
| 19 | Salivary cortisol and de- hydroepiandrosterone (DHEA) levels, psychological factors in pa- tients with oral lichen planus显示文摘 | Girardi C Luz C Cherubini K | 2011 | Arch Oral Biol2011，56，9： | 1 |
| 20 | Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder 显示文摘 | Dias G P Bevilaqua M C da Luz A C | 2014 | Behav Brain Res2014，15，263： | 1 |
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