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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Reactive Phenylben- zimidazole UV Absorbers and Their Application to Cellulose Textiles 显示文摘 | Lubomir K Jiri A Ladislav B | 2009 | JApplPolym Sci2009，112，6： | 1 |
| 3 | Involvement of free radicals in dementia of the Alzheimer type:a hypothesis显示文摘 | Ladislav Volicer Peter B Crino | | 0，，05： | 1 |
| 4 | Volcanic facies analysis of a subaqueous basalt lava flow com- plex at Hrugkovec, NW Croatia: Evidence of advanced rifting in the Tethyan domain 显示文摘 | Ladislav A P Vladimir B Sibila B S | 2008 | Journal of Volcan- ologyand Geothermal Research2008，178，： | 1 |
| 5 | Structural characterization of photosystem 1] complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex 显示文摘 | Ladislav B Helena H D Michal H | 2005 | European Journal of Bio- chemist2005，271，14： | 1 |
| 6 | Structural characterization of photosystem II complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex显示文摘 | Ladislav B Helena H D Michal H | 2005 | European Journal of Biochemist2005，271，： | 1 |
| 7 | Presymptomatic spondylotic cervical cord compression显示文摘 | Josef B Zdenek Ladislav D | | 0，，20： | 1 |
| 8 | Structural characterization of photosystem Ⅱ complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex Eur显示文摘 | Ladislav B Helena H D Michal H | 2005 | Biochemist2005，271，： | 1 |
| 9 | Suspended bridges subjected to moving loads and support motions due to earthquake显示文摘 | LADISLAV F B YAU J D | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
| 10 | Suspended bridges subjected to moving loads and support motions due to earthquake显示文摘 | LADISLAV F B YAU J D | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
| 11 | Evaluation of financing possibilities ofsmall and medium industrial enterprises显示文摘 | LADISLAV M jAN B | 2010 | Procedia Economicsand Finance2010，3，21： | 1 |
| 12 | Volcanic facies analysis of a subaqueous basalt lava-flow complex at Hrukovec,NW Croatia:Evidence of advanced rifting in the Tethyan domain显示文摘 | Ladislav A P Vladimir B Sibila B S | 2008 | Journal of Volcanology and Geothermal Research2008，178，： | 1 |
| 13 | Thermal processing of sewage sludge 显示文摘 | Pavel S Jaroslav B Ladislav B | 2006 | Applied Thermal Engineering2006，26，： | 1 |
| 14 | Fracture characteristics of thermally exposed 9Cr-IMo steel after tensile and im- pact testing at room temperature 显示文摘 | Juraj B Ladislav F Peter S | 2009 | Engineering Fail- ure Analysis2009，16，5： | 1 |
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