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| 1 | Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization显示文摘客观:血浆 phospholipid 转移蛋白质(PLTP ) 是脂蛋白新陈代谢的一个关键决定因素,并且动物和人的研究收敛显示 PLTP 支持 atherogenesis 和它的 thromboembolic 复杂并发症。而且, PLTP 调制发炎和有免疫力的回答,这最近被报导了。尽管从我们的组的更早的研究证明 PLTP 能修改巨噬细胞激活,在 T-cell-mediated 有免疫力的回答的调整的 PLTP 的含意从来没被调查过并且因此在现在的学习被探讨。途径和结果:在现在的学习,我们证明在老鼠的那 PLTP 缺乏在 CD4 + Th0 房间极化上有深刻效果,与向在正常、病理学的条件下面的反煽动性的 Th2 显型的移动。在接触超敏性的一个模型,对有 hapten-2,4-dinitrofluorobenzene (DNFB ) 的皮肤促进感受性的显著地损害的回答在 PLTP 缺乏的老鼠被观察与相比野类型(WT ) 老鼠。有趣地,在老鼠的 PLTP 缺乏没在外部血在全部的白血房间,淋巴细胞, granulocytes,或单核白血球的计数上施加效果。而且, PLTP 缺乏没修改 CD4 + 和 CD8 + T 淋巴细胞子集的数量。然而, PLTP 缺乏,与 Th2 显型的 upregulation 联系了,被重要减少在 pro-Th1 cytokine interleukin 的生产伴随 18 由附件房间。结论:第一次,这个工作向支持 inflammatory Th1 显型在 CD4 + T 房间的极化为 PLTP 报导一个生理的角色。 | Catherine Desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie Deckert Jean-Paul Pais de Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 2 | Elevation of systemic PLTP, but not macrophage- PLTP, impairs maeropbage reverse cholesterol transport in transgenic mice显示文摘 | Tzotzas T Desrumaux C Lagrost L | 2009 | Atherosclerosis2009，204，2： | 1 |
| 3 | Electrochemical reactivity in room-temperature ionic liquids显示文摘 | Hapiot P Lagrost C | 2008 | Chemical Reviews2008，108，7： | 1 |
| 4 | The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis显示文摘 | MASSON Dr JIANG X C LAGROST L | 2009 | J Lipid Res2009，，： | 1 |
| 5 | Electrochemical reactivity in room-tem-perature ionic liquids显示文摘 | HAPIOT P LAGROST C | 2008 | Chem Rev2008，108，： | 1 |
| 6 | The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis显示文摘 | MASSON D JIANG X C LAGROST L | 2009 | J Lipid Res2009，，： | 1 |
| 7 | 显示文摘 | Bernard S Moulin P Lagrost L | 1998 | J Lipid Res1998，39，1： | 1 |
| 8 | Electrochemical reactivity in room- temperature ionic liquids 显示文摘 | Hapiot P Lagrost C | 2008 | Chemical Reviews2008，108，7： | 1 |
| 9 | The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis显示文摘 | Masson D Jiang XC Lagrost L | | 0，，50： | 1 |
| 10 | Structure and function of the plasma phospholipid transfer protein 显示文摘 | Desrumaux C Masson D | 1998 | Curr Opin Lipidol1998，9，： | 1 |
| 11 | The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis 显示文摘 | Masson D Jiang XC Lagrost L | 2009 | J Lipid Res2009，，： | 1 |
| 12 | Competitive enzyme-linked immunosorbent assay of the human eholesteryl ester transfer protein (CETP) 显示文摘 | Guyard-Dangremont V Lagrost L Gambert P | 1994 | Clin Chim Acta1994，231，2： | 1 |
| 13 | Intellectual property valuation : how to approach the selection of an ap-propriate valuation method 显示文摘 | Celine Lagrost Donald Martin Cyrille Dubois and Sere Quazzotti | 2010 | Journal of Intellectual Capital2010，11，4： | 1 |
| 14 | Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice显示文摘 | Anne Laure Sberna Mahfoud Assem Thomas Gautier Jacques Grober Boris Guiu Aline Jeannin Jean-Paul Pais de Barros Anne Athias Laurent Lagrost David Masson | 2010 | Journal of Hepatology2010，，1： | 1 |
| 15 | Variation at the apo AⅠ/ CⅢ/AⅣ gene complex is associated with elevated plasma levels of apo CⅢ显示文摘 | Shoulders CC Harry PJ Lagrost L | 1991 | Atherosclerosis1991，87，23： | 1 |
| 16 | 查看详情显示文摘 | Lagrost C Alcaraz G Bergamini J.F Fabre B Serbanescu | | 0，，： | 1 |
| 17 | Variation at the AⅠ/CⅢ/AⅣ gene complex is associated with elevated plasma levels of apoCⅢ显示文摘 | Shouders CC Harry PJ Lagrost L | 1991 | Atherosclerosis1991，87，： | 1 |
| 18 | Structure and function of the piasma phospholipid transfer protein显示文摘 | Lagrost L Desrumaux C Masson V D | 1998 | Curt Opin Lipidol1998，9，： | 1 |
| 19 | Changes in lipoprotein kinetics associated with type 2 diabetes affect the distribution of lipopolysaccharides among lipoproteins显示文摘 | Verges B Duvillard L Lagrost L | 2014 | J Clin Endocrinol Metab2014，99，7： | 1 |
| 20 | Specific effects of room-temperature ionic liquids on cleavage reactivity: Example of the carbon-halogen bond breaking in aromatic radical anions 显示文摘 | LAGROST C GMOUH S VAULTIER M HAPIOT P | 2004 | J Phys Chem A2004，108，： | 1 |
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