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| 1 | Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity显示文摘Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the world.It is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin action.It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030.Even though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far.Thus,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder.The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays.Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug.This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model.From the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite.Thus,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder. | Patel DK Kumar R Laloo D Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 17 |
| 2 | Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) F.Muell. (Violaceae).显示文摘Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus(H.enneaspermus) Linn F.Muell.family(Violaceae). Methods:Different fractions of H.enneaspermus were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide(NO),hydrogen peroxide(H2O2) scavenging assays.Results:The ethyl acetate(EA) fraction was found to have high levels of phenolic content[(212.15±0.79) mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[(127.07±2.29) Fg/mL],nitric oxide[(245.16±1.44)μg/mLJ,hydrogen peroxide[(227.38±7.18)μg/mL],deoxyribose[(270.61±8.72)μg/mL]and higher reducing power.There was a significant correlation between total phenolic content and total antioxidant activity(r =0.972). Conclusions:These results reveal that EA fraction of H.enneaspermus has strong antioxidant potential compared with other fractions.Our further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property. | Dinesh Kumar Patel Rajesh Kumar Damiki Laloo Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 7 |
| 3 | Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro显示文摘Objective:To assesse the inhibitor) effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler and.Alangium lamarckii Thwaits on aldose reductase(AR) of rat lens.Methods:Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein content.Results:The alcoholic extract of Ceasalpirda digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR enzyme.The IC50 values of alcoholic extract of the selected plants were calculated and were(46.29±11.17) and(106.00±5.11)μg/mL,respectively. Quercetin was used as a positive control and its IC50 value was(2.95±1.53)μg/mL.Conclusions:Thus,it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro. | Rajesh Kumar Dinesh Kumar Patel Damiki Laloo Krishnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 4 | Pedalium murex Linn.:An overview of its phytopharmacological aspects显示文摘Pedalium murex Linn(family:Pedaliaceae)(P.murex) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern part.Deccan region of India and in some parts of Ceylon.Different parts of the plant are used to treat various ailments like,cough,cold and as an antiseptic.Interestingly.P.murex is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in men.nocturnal emissions,gonorrhoea as well as leucorrhoea in women.The plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract disorders.Phytochemically the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin alkaloids.Other phytochemicals reported in the plant includes quercetin.ursolic acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,nonacosane.tritriacontane.tetratriacontanyl and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. nephroprotective.hypolipidemic,aphrodisiac,antioxidant,antimicrobial and insecticidal activities.From all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic disease.The overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for P.murex published so far. | Dinesh Kumar Patel Damiki Laloo Rajesh Kumar Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 3 |
| 5 | Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects显示文摘 | DK Patel R Kumar D Laloo S Hemalatha | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 2 |
| 6 | A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X- linked chondrodysplasia显示文摘 | Simon D Laloo B Barillot M | 2010 | Hum Mol Genet2010，19，： | 1 |
| 7 | Sever and complicated malaria in Melanesian adults in New Guinea 显示文摘 | Laloo DJ Trevett AJ Paul M | 1996 | Am J Trop Med Hyp1996，55，： | 1 |
| 8 | Sever and complicated malaria in Melanesian adults in new Guinea显示文摘 | Laloo DJ Trevett AJ Paul M | | 0，，： | 1 |
| 9 | Type 2 antidiabetic activity of bergenin from the roots of Caesalpinia digyna Rottler显示文摘 | Rajesh Kumar Dinesh K. Patel Satyendra K. Prasad Damiki Laloo Sairam Krishnamurthy S. Hemalatha | 2011 | Fitoterapia2011，，2： | 1 |
| 10 | African dust clouds are associated with increased paediatric asthma accident and emergency admissions on the Caribbean island of Trinidad显示文摘 | K. Gyan W. Henry S. Lacaille A. Laloo C. Lamsee-Ebanks S. McKay R. M. Antoine M. A. Monteil | 2005 | International Journal of Biometeorology2005，，6： | 1 |
| 11 | A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia 显示文摘 | Simon D Laloo B Barillot M | 2010 | Human molecular genetics2010，19，10： | 1 |
| 12 | Saharan dust clouds and paediatric asthma in the Caribbean Island of Trinidad显示文摘 | Keshav Gyan Winoah Henry Sherard Lacaille Anita Laloo Chela Lamsee-Ebanks Samantha McKay Beverley Gulston Robin M. Antoine Michele A Monteil | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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