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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 3 | Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease显示文摘AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess. | Indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 4 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 5 | Meshfree particle simulation of file explosion profess for high explosive in shaped charge unlined cavity configurations显示文摘 | Lin M B Liu G R Lam K Y | 2003 | Shock Waves2003，12，6： | 1 |
| 6 | The acute effects of meno (2- ethylhexyl) phthalate (MEHP) on testes of prepubertal wistar rats显示文摘 | Dalgaard M Nellemann C Lam H R | 2001 | Toxicol Lett2001，122，1： | 1 |
| 7 | Relationship of gabbro and pillow lavas in the Lupar Formation, West Sarawak: implications for the interpretation of the Lubok Antu M lange and the Lupar Line显示文摘 | Haile N S Lam S K Banda R M | 1994 | Bulletin of the Geological Society of Malaysia1994，36，： | 1 |
| 8 | Recovery of lost or erroneously received motion vectors显示文摘 | Lam W M Reibman A R Liu B | 1993 | Minneapolis MN USA:Proceedings of ICASSP''93 Acoustics1993，5，4： | 1 |
| 9 | The acute effects of mono (2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats显示文摘 | Dalgaard M Nellemann C Lam H R | 2001 | Toxicol Lett2001，122，1： | 1 |
| 10 | Three-dimensional ultrasound features of the polycystic ovary and the effect of different phenotypic expressions on these parameters显示文摘 | LAM P M JOHNSON I R RAINE-FENNING N J | 2007 | Hum Reprod2007，22，12： | 1 |
| 11 | Culturing aerobic and anaerobic bacteria and mammalian cells with a microfluidic differential oxygenator 显示文摘 | LAM R H W KIM M C THORSEN T | 2009 | Anal Chem2009，81，14： | 1 |
| 12 | Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects显示文摘 | HOLMES M M GALEA LAM MISTLBERGER R E | 2004 | J Neuro Res2004，76，： | 1 |
| 13 | A one-dimensional meshfree parti-cle formulation for simulating shockwaves 显示文摘 | Liu M B Liu G R Lam K Y | 2003 | Shock Waves2003，13，3： | 1 |
| 14 | Numerical simulation of cross-flow around four cylinders in an in-line square configura- tion显示文摘 | Lam K Gong W Q So R M C | 2008 | Journal of Fluids and Structures2008，24，1： | 1 |
| 15 | Hyperglycemia and neurologic outcome in patient with head injury显示文摘 | LAM A M WINN H R CULLEN B F | 1991 | J Neurosurg1991，75，4： | 1 |
| 16 | Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine显示文摘 | Bouchard M J Lam D H Racaniello V R | 1995 | J Virol1995，69，8： | 1 |
| 17 | Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats显示文摘 | Majken Dalgaard Ulla Hass Anne Marie Vinggaard Kirsten Jarfelt Henrik R Lam Ilona K S?rensen Helle M Sommer Ole Ladefoged | 2003 | Reproductive Toxicology2003，，2： | 1 |
| 18 | EDTA is a better anticoagulant than heparin or citrate for delayed blood processing for plasma DNA analysis显示文摘 | Lam N Y Rainer T H Chiu R W Lo Y M | 2004 | Clin Chem2004，50，： | 1 |
| 19 | The acute effects of mono(2-ethylhexyl) phthalate (MEHP) ontestes of prepul)ertal Wistar rats显示文摘 | Dalgaard M Nellemann C Lam H R | 2001 | Toxicol Lett2001，122，： | 1 |
| 20 | Lessons from co-development of a single vessel processor: Meth- odologies for managing innovation in customer-supplier networks 显示文摘 | LAMMING R HAJEE D HORRILL M | 2002 | International Journal of Technology Man- agement2002，23，13： | 1 |
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