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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells 显示文摘 | Lammering G Lin PS Contessa JN | 2001 | Int J Radiation Oncology Biol Phys2001，51，3： | 1 |
| 3 | 查看详情显示文摘 | Lash T D Lammer A D Ferrence G M | | 0，，41： | 1 |
| 4 | Altered skin-temperature regulation in narcolepsy relates to sleep propensity 显示文摘 | Fronczek R Overeem S Lammers G J | 2006 | Sleep2006，29，11： | 1 |
| 5 | Dual Principles in Frame Theory显示文摘 | CASAZZA P G KUTYNIOK G LAMMER M C | 2004 | J Fourier Anal Appl2004，10，： | 1 |
| 6 | Contrastenhanced three-dimensional transcranial color-coded sonography of intracranial stenosis显示文摘 | Klotzsch C Bozzato A Lammers G | 2002 | AJNR2002，30，： | 1 |
| 7 | Shortterm hypofractionate radiotherapy followed by total mesorectal excision显示文摘 | Lammering G Hartmann K A Frenken M | 2000 | Strahlenther Onkol2000，176，12： | 1 |
| 8 | Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization显示文摘 | Lammering G Hewit T H Hawkins W T | 2001 | Natl Cancer Inst2001，9，12： | 1 |
| 9 | The hypothalamus in episodic brain disorders 显示文摘 | Overeem S van Vliet JA Lammers G J | 2002 | Lancet Neurol2002，1，7： | 1 |
| 10 | Endoluminal Stent-grafts for Infrarenal Abdominal Aortic Aneurysms显示文摘 | Blum U Voshage G Lammer J | | 0，，： | 1 |
| 11 | Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cell显示文摘 | Contessa JN Hampton J Lammering G | 2002 | Oncogene2002，21，25： | 1 |
| 12 | Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor 显示文摘 | Lammering G Valerie K Lin PS | 2001 | Clin Cancer Res2001，7，： | 1 |
| 13 | Contrast-enhanced three-dimensional transcranial color-coded sonography of intracranial stenoses显示文摘 | Klotzsch C Bozzato A Lammers G | 2002 | Am J Neuroradiol2002，23，2： | 1 |
| 14 | Radiation-inducedactivation of a common variant of EGFR confers enhancedradioresistance显示文摘 | Lammering G Valerie K Lin PS | 2004 | Radiother Oncol2004，72，3： | 1 |
| 15 | Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease显示文摘 | Matuschek C B(o)lke E Lammering G | 2010 | Eur J Med Res2010，15，： | 1 |
| 16 | Upregulation of skeletal muscle inflammatory genes links inflammation with insulin resistance in women with the metabolic syndrome显示文摘 | Poelkens F Lammers G Pardoel EM | 2013 | Exp Physiol2013，98，10： | 1 |
| 17 | Endoluminal stentgrafts for infrarenal abdominal aortic aneurysms显示文摘 | Voshage G Lammer J | 1997 | N Engl J Med1997，336，： | 1 |
| 18 | Is the fish embryotoxicity test(FET)with the zebrafish(Danio rerio)a potential alternative for thefish acute toxicity test?显示文摘 | Lammer E Carr G Wendler K | 2009 | Comp Biochem Physiol2009，149，2： | 1 |
| 19 | Endoluminal stent-grafts for infrarenal abdominal aortic aneurysms 显示文摘 | Voshage G Lammer J | 1997 | N Engl J Med1997，336，： | 1 |
| 20 | Dynamin binds to SH3 domains of phospholipase Cgamma and GRB-2 显示文摘 | Seedorf K Kostka G Lammers R | 1994 | J Biol Chem1994，269，16： | 1 |
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