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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | ^(99m)Tc-MIBISPECT检测梗塞区存活心肌(与^(18)F-FDGPET结果比较)显示文摘评价99mTc-甲氧基异丁基异腈(MIBI)SPECT定量分析在心肌梗塞(MI)区存活心肌判断中的准确性,及视觉判断99mTc-MIBISPECT结果在缺血与坏死心肌鉴别中的局限性.方法:34例MI患者进行了99mTc-MIBISPECT心肌灌注显像及18F标记的脱氧葡萄糖(FDG)PET显像.结果:当局部心肌99mTc-MIBI放射性小于左室心肌峰计数的40%,存活心肌存在的可能性仅为24%左右;相反,当局部99mTc-MIBI放射性大于左室心肌峰计数的40%,则90%以上的心肌节段均为存活心肌.故视觉判断不可逆性缺损明显低估存活心肌.约59%的不可逆性缺损节段在PET显像中有明确18F-FDG摄取,提示为存活心肌.结论:99mTc-MIBISPECT定量分析能明显提高存活心肌的定位诊断,慎重判断及定义心肌灌注显像中的不可逆性缺损区,重视定量分析的研究及应用对MI区存活与坏死心肌的鉴别诊断有重要价值. | 黄钢 赵惠扬 陈可靖 Landoni C Lucignani G Fazio F | 1995 | 中华核医学杂志1995，15，3： | 9 |
| 3 | Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors显示文摘AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral center.METHODS Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and CT.RESULTS Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and pathology.CONCLUSION MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET. | Salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni | 2017 | World Journal of Gastroenterology2017，23，17： | 4 |
| 4 | Pancreaticoduodenectomy in patients ≥ 75 years of age:Are there any differences with other age ranges in oncological and surgical outcomes? Results from a tertiary referral center显示文摘AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy(PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years(late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic and pathological features and survival outcomes of LE patients with 2 exact matched cohorts of younger patients [≥ 40 to 64 years of age(adults, A) and ≥ 65 to 74 years of age(young elderly, YE)] submitted to PD, according to selected variables. RESULTS The final LE population, as well as the control groups, were made of 96 subjects. Up to 71% of patients was operated on for a periampullary malignancy and pancreatic cancer(PDAC) accounted for 79% of them. Intraoperative data(estimated blood loss and duration of surgery) did not differ among the groups. The overall complication rate was 65.6%, 61.5% and 58.3% for LE, YE and A patients, respectively, P = NS). Reoperation and cardiovascular complications were significantly more frequent in LE than in YE and A groups(P = 0.003 and P = 0.019, respectively). When considering either all malignancies and PDAC only, the three groups did not differ in survival. Considering all benign diseases, the estimated mean survival was 58 and 78 mo for ≥ and < 75 years of age(YE + A groups), respectively(P = 0.012). CONCLUSION Age is not a contraindication for PD. A careful selection of LE patients allows to obtain good surgical and oncological results. | Salvatore Paiella Matteo De Pastena Tommaso Pollini Giovanni Zancan Debora Ciprani Giulia De Marchi Luca Landoni Alessandro Esposito Luca Casetti Giuseppe Malleo Giovanni Marchegiani Massimiliano Tuveri Enrico Marrano Laura Maggino Erica Secchettin Deborah Bonamini Claudio Bassi Roberto Salvia | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 5 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 6 | Usability and impact of digital libraries: a review显示文摘 | Sudatta Chowdhury Monica Landoni Forbes Gibb | 2006 | Online Information Review2006，，6： | 2 |
| 7 | Radiation exposure of person- nel during intraoperative radiotherapy(IORT) : radiation protection aspects显示文摘 | Strigari L Soriani A Landoni V | 2004 | J Exp Clin Cancer Res2004，23，3： | 1 |
| 8 | The incidence and risk of acute renal failure after cardiac surgery显示文摘 | Bove T Calabro MG Landoni G | | 0，，02： | 1 |
| 9 | Cardiac protection by volatile anaesthetics, a multicentre randomized controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass显示文摘 | TRITAPEPE L LANDONI G GUARRACINO F | 2007 | Eur J Anaesthesiol2007，24，4： | 1 |
| 10 | Analysis of treatment failures and survival of patients with fallopian tube carcinoma:a cooperation task force(CTF)study显示文摘 | Gadducci A Landoni F Sartori E | 2001 | Gynecol Oncol2001，81，： | 1 |
| 11 | Desflurane and sevoflurane in eardiac surgery: a meta - analysis of ran- domized clinical trials 显示文摘 | Landoni G Biondi - Zoccai GGL Zangrillo A | 2007 | Journal of cardiothoracic and vas- cular anesthesia2007，21，4： | 1 |
| 12 | Serum half- life of CA125 during early chemotherapy as an iudependent prognostic variable for patients with advanced epithelial ovarian cancer: results of a multieentric Italian study 显示文摘 | GADDUCCI A ZOLA P LANDONI F | 1995 | Gynecol Oncol1995，58，1： | 1 |
| 13 | Early lung cancer detection with spiral CT and positron emission tomography in heavy smokers:2-year results显示文摘 | Pastorino U Bellomi M Landoni C | 2003 | Lancet2003，362，： | 1 |
| 14 | The incidence and risk of acute renal failure after cardiac surgery显示文摘 | Bore T Calabro M Landoni G | | 0，，04： | 1 |
| 15 | Chemo-conization in early cervical cancer显示文摘 | Landoni F Parma G Peiretti M | | 0，，1： | 1 |
| 16 | E - Books, e - publishers and e - book builders for children显示文摘 | Shiratuddin N Landoni M | 2002 | New Review of Children''s Literature and Librarianship2002，8，1： | 1 |
| 17 | Fluorodeoxyglucose positron emission tomography improves preoperative staging of resectable lung metastasis显示文摘 | Pastorino U Veronesi G Landoni C | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 18 | Comparison ofdual-head coincidence PET versus ring PET in tumor patients显示文摘 | Landoni C Gianolli L Lucignani G | 1999 | J Nucl Med1999，40，10： | 1 |
| 19 | Myocardial damage prevented by volatile anesthetics: a muhicenter randomized controlled study显示文摘 | GUARRACINO F LANDONI G TRITAPEPE L | 2006 | J Cardiothorac Vasc Anesth2006，20，4： | 1 |
| 20 | Neoadjuvant che- motherapy prior to pelvic exenteration in patients with recur- rent cervical cancer: single institution experience 显示文摘 | Landoni F Zanagnolo V Rosenberg PG | 2013 | GynecolOncol2013，130，1： | 1 |
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