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| 1 | Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances显示文摘Colorectal anastomotic leakage(CAL) remains a major complication after colorectal surgery. Despite all efforts during the last decades, the incidence of CAL has not decreased. In this review, we summarize the available strategies regarding prevention, prediction and intervention of CAL and categorize them into three categories: communication, infection and healing disturbances. These three major factors actively interact during the onset of CAL. We aim to provide an integrated approach to CAL based on its etiology. The intraoperative air leak test, intraoperative endoscopy, radiological examinations and stoma construction mainly aim to detect and to prevent communication between the intra- and extra-luminal content. Other strategies including postoperative drainage, antibiotics, and infectious-parameter evaluation are intended to detect and prevent anastomotic or peritoneal infection. Most currently available interventions for CAL focus on the control of communication and infection, while strategies targeting the healing disturbances such as lifestyle changes, oxygen therapy and evaluation of metabolic biomarkers still lack wide clinical application. This simplified categorization may contribute to an integrated understanding of CAL. We strongly believe that this integrated approach should be taken into consideration during clinical practice. An integrated approach to CAL could contribute to a better understanding of the etiology of CAL and eventually better patient outcome. | Cloe L Sparreboom Zhou-Qiao Wu Jia-Fu Ji Johan F Lange | 2016 | World Journal of Gastroenterology2016，22，32： | 9 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | Heterogeneous nucleating in the crystallization of polyolefins:Part 2 Kinetics of crystallization of nucleated polyolefins显示文摘 | Binsbergen F L De Lange B G M | 1970 | Polymer1970，11，6： | 2 |
| 4 | Early clinical worsening in patients with TIA or minor stroke: The Austrian Stroke Unit Registry显示文摘 | J Ferrari M Knoflach S Kiechl J Willeit S Schnabl L Seyfang W Lang | 2010 | Neurology2010，，2： | 2 |
| 5 | The epidemiological study of women with urinary incontinence and risk factors for stress urinary incontinence in China显示文摘 | Zhu L Lang J Liu C | 2009 | Menopause2009，16，4： | 1 |
| 6 | Disentangling the Incentive and entrenchment effects of large Shareholdings 显示文摘 | Claessens S Djankov S FAN J Lang L H P | 2002 | Journal of Finance2002，57，6： | 1 |
| 7 | Hydrothermal epitaxy of KTaO3 thin films显示文摘 | GOH G K L LEVI C G LANGE F F | 2002 | J Mater Res2002，17，11： | 1 |
| 8 | Detection of residual toxin in tissues of ricin-poisoned mice by sandwich enzyme-linked immunosorbent assay and immunoprecipitation显示文摘 | Men J Lang L Wang C | 2010 | Anal Biochem2010，401，2： | 1 |
| 9 | Recruitment of knee joint ligaments显示文摘 | Blankevoort L Huiskes R De Lange A | 1991 | ASME J Biomech Eng1991，113，1： | 1 |
| 10 | Application of flowcytometry and fluorescent in situ hybridization for assessment of exposures to airborne bacteria显示文摘 | Lange J L Thorne P S Lyncjh N 2001 | 2001 | Applied and Environmental Microbiology2001，63，4： | 1 |
| 11 | Engineering a recombinant Deinococcus radiodurans for ollganopollutant degradation in radioactive mixed waste environment 显示文摘 | LANGE C C WACKETT L P MINTON K W | 1998 | Nat Biotechnol1998，16，10： | 1 |
| 12 | High- level expression of the native barley u-amylase/subtili- sin inhibitor in Pichia pastoris显示文摘 | Micheelsen P O lDstergaard P R Lange L | 2008 | J Biotechnol2008，133，： | 1 |
| 13 | The epidemiological study of women with urinary incontinence and risk factors for stress urinary inconti- nence in China 显示文摘 | Zhu L Lang J Liu C | 2009 | Menopause2009，16，4： | 1 |
| 14 | The Reaction of a Phosphorus Ylide with Aroyl Cyanides显示文摘 | Soulen R L Carlson S D Lang F | 1973 | J Org Chem1973，38，3： | 1 |
| 15 | FDA issues statement on diethylene glycol and melamine food contamination显示文摘 | Lang L | 2007 | Gastroenterology2007，133，1： | 1 |
| 16 | Temporary cov- ers maintain fall bermudagrass quality, enhance spring green- up, and increase stem carbohydrate levels 显示文摘 | Goatley J M Maddox V L Lang D L etal | 2005 | HortScienee2005，40，1： | 1 |
| 17 | Three - dimensional ech- ocardiography: The benefits of the additional dimension 显示文摘 | Lang RM Mor - Avi V Sugeng L | 2006 | J Am Coil Cardiol2006，48，： | 1 |
| 18 | The Separation of Ownership and Control in East Asian Corporations 显示文摘 | Claessens S Djankov S Lang L H P | 2000 | Journal of Fi- nancial Economics2000，58，1： | 1 |
| 19 | The antisecretory factors:inducible proteins which modulate secretion in the small intestine显示文摘 | L nnroth I Lange S Skadhuge E | 1988 | Comp Biochem Physiol1988，，90： | 1 |
| 20 | Me or we: The effects of CEO organizational identification on agency costs显示文摘 | Boivie S Lange D McDonald M L | 2011 | Academy of Management Journal2011，54，3： | 1 |
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