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| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | Oral manifestation in inflammatory bowel disease:A review显示文摘Inflammatory bowel diseases(IBDs),including Crohn’s disease(CD)and ulcerative colitis,not only affect the intestinal tract but also have an extraintestinal involvement within the oral cavity.These oral manifestations may assist in the diagnosis and the monitoring of disease activity,whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups.Indurated tag-like lesions,cobblestoning,and mucogingivitis are the most common specific oral findings encountered in CD cases.Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of IBD.In differential diagnosis,side effects of drugs,infections,nutritional deficiencies,and other inflammatory conditions should also be considered.Treatment usually involves managing the underlying intestinal disease.In severe cases with local symptoms,topical and/or systemic steroids and immunosuppressive drugs might be used. | Kamran B Lankarani Gholam Reza Sivandzadeh Shima Hassanpour | 2013 | World Journal of Gastroenterology2013，19，46： | 10 |
| 3 | Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases显示文摘瞄准:发现是否在与 cagA 地位一起的 IL-8 基因的功能的倡导者多型性和在基因影响的休假的多型性在伊朗的病人的疾病的类型由 H pylori 感染了。方法:IL-8 -251 A/T 多型性在有经历上面的胃肠的内视镜检查法的 H pylori 感染的 233 个病人的一件样品是由 oligonucleotide 等位基因 specific PCR (ASO-PCR ) 的 genotyped。在基因也是的休假的 cagA 基因和多型性的存在由 PCR 决定了。有胃炎,消化性溃疡以及胃的癌症的发展的这些基因多型性的协会被测试。结果:当有不同临床的表明的病人根据 cagA 基因或各种各样的休假 A 遗传型的存在被比较时,仅仅休假 A 遗传型在胃炎,消化性溃疡和胃的癌症病人之中是显著地不同的(chi 2 = 17.8;P = 0.001 ) 。而且,在在有胃的癌症和良性的疾病的病人之间的 IL-8 -251 A/T 遗传型的频率有有效差量(chi 2 = 10.47;P = 0.005 ) 。结论:在 H pylori 休假的 IL-8 -251 A/T 多型性和多型性基因涉及限制感染结果到胃炎和消化性溃疡或在在伊朗的病人赞成癌症发作。 | Eskandar Kamali-Sarvestani Abdulah Bazargani Malihe Masoudian Kamran Lankarani Ali-Reza Taghavi Mehdi Saberifiroozi | 2006 | World Journal of Gastroenterology2006，12，32： | 6 |
| 4 | Fatal motorcycle accidents in Fars Province, Iran: a com- munity-based survey显示文摘ObjectiveTo 在 Fars 省识别摩托车事故的牺牲品的主要特征, Iran.MethodsThis 代表性的学习在从 2009 年 3 月在伊朗有所有 31 个省的第四张最大的人口到 2010 年 6 月的 Fars 省被进行。我们从所有 542 的 includeddata 由于机动车辆事故记录了死亡的盒子。数据从由人口统计、事故相关的信息组成的法庭的药登记被记录。人口统计的信息由名字,年龄,性别,致命的牺牲品(摩托车驱动程序对旅客) 的地位和 2 345 尸体从法庭的药档案记录的教育 level.ResultsOf 组成了,(23.1%) 542 作为机动车辆事故给了死亡的原因。这些牺牲品的吝啬的年龄是(31.4 ±16.5 ) 年,和男性到女比率是 28。头损害是在这些牺牲品的死亡的最普通的原因,并且总的来说,他们趋于有教育的底层。摩托车事故经常包含了更年轻的年龄组(15-35 年) ,并且与一顶头盔的弃权联系的头损伤是 death.ConclusionsHead 损害的最普通的原因在在我们学习了的省的牺牲品之中是经常的。这种状况可能与 victims’ 有关关于交通法律与他们的弱实施一起导致加速和这些法律的不顾的低社会经济的地位和很少教育。 | Seyed Taghi Heydari Najmeh Maharlouei Aft Foroutan Yaser Sarikhani Fariborz Ghaffarpasand Arya Hedjazi Mohammad Zarenezhad Ghasem Moafian Mohammad Reza Aghabeigi Payam Peymani Seyed Mehdi Ahmadi Maryam Dehghankhalili Hassan Joulaei Kamran B. Lankarani | 2012 | Chinese Journal of Traumatology2012，15，4： | 6 |
| 5 | COVID-19 infection and liver injury:Clinical features,biomarkers,potential mechanisms,treatment,and management challenges显示文摘It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical presentations.Liver injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 patients.In addition to the common hepatobiliary disorders caused by COVID-19,patients with pre-existing liver diseases demand special considerations during the current pandemic.Thus,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver failure.Careful monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metabolic liver injury.The purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerable patients with pre-existing liver injury.This review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients. | Gholam Reza Sivandzadeh Hassan Askari Ali Reza Safarpour Fardad Ejtehadi Ehsan Raeis-Abdollahi Armaghan Vaez Lari Mohammad Foad Abazari Firoozeh Tarkesh Kamran Bagheri Lankarani | 2021 | World Journal of Clinical Cases2021，9，22： | 5 |
| 6 | Epidemiological characteristics of fatal pedestrian ac- cidents in Fars Province of Iran: a community-based survey显示文摘ObjectiveTo 决定在 Iran.MethodsThis 代表性的学习的 Fars 省的致命的步行事故的流行病学的特征从 2009 年 3 月在一个 29 月的时期期间在伊朗的 Fars 省被进行到 2011 年 7 月。数据从 Fars 法庭的药登记。在 4 923 记录道路交通事故死亡, 971 死亡由于步行事故。人口统计、事故相关的信息被社会科学统计套装软体版本 11.5 分析。不到 0.05 被认为死者的 significant.ResultsThe 平均数年龄的 P 价值是(47.2 ±26.2 ) 年,从 6 个月到 103 岁。男性们说明了 69.8% 所有死亡。致命的事故在 9 月是很普通的;56.1% 致命的损害发生在 intracity 道路上并且 33.1% 在 extracity 道路上。致命的头损害在 60.54% 盒子中是在场的。损害地点的评估和死亡的原因发现他们显著地与年龄被联系,在损害和死亡之间的间隔。而且,道路的类型在 mortality.ConclusionAlthough 起了一个重要作用损伤病人的临床的管理在最近的十年在我们的国家被改进了,减少损害的负担在损伤系统组织之中需要协作。 | Payam Peymani Seyed Taghi Heydari Amin Hoseinzadeh Yaser Safikhani Arya Hedjazi Mohammad Zarenezhad Ghasem Moafian Mohammad Reza Aghabeigi Najmeh Maharlouei All Foroutan Seyed Mehdi Ahmadi FariborzGhaffarpasand Hassan Joulaei Kamran B Lankarani | 2012 | Chinese Journal of Traumatology2012，15，5： | 5 |
| 7 | Promoter polymorphism of transforming growth factor-β1 gene and ulcerative colitis显示文摘AIM: To elucidate the possible difference in two promoter polymorphisms of the transforming growth factor-β1 (TGF-β1) gene (-800G > A, -509C > T) between ulcerative colitis (UC) patients and normal subjects.METHODS: A total of 155 patients with established ulcerative colitis and 139 normal subjects were selected as controls. Two single nucleotide polymorphisms within the promoter region of TGF-β1 gene (-509C > T and -800G > A) were genotyped using PCR-RFLP. RESULTS: There was a statistically significant difference in genotype and allele frequency distributions between UC patients and controls for the -800G > A polymorphism of the TGF-β1 gene (P < 0.05). The frequency of the TGF-β1 gene polymorphism at position -800 showed that the AA genotype and the allele A frequencies significantly differed between the patients and healthy controls (P < 0.05). At position -509, there was no statically significant difference in genotype and allele frequency between the patients and control subjects.CONCLUSION: The results of our study indicate that there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-β1 gene promoter between Iranian patients with UC and normal subjects. | B Tamizifar KB Lankarani S Naeimi M Rismankar Zadeh A Taghavi A Ghaderi | 2008 | World Journal of Gastroenterology2008，14，2： | 4 |
| 8 | Educational level and age as contributing factors to road traffic accidents显示文摘在 Fars 省的道路交通事故(RTA ) 上的 ObjectiveThis 研究分析数据,其道路在在伊朗的高度危险的之中。它调查涉及 RTA 以便发现能阻止或减少的模式的教育水平和年龄 accidents.MethodsThis 研究使用了数据可视化技术发现模式隐藏。数据在 Fars 省包括了与 RTA 有关的死亡率并且从从 2010 年 3 月 21 日盖住 1 年的一个时期到 2011 年 3 月 21 日的 Fars 法庭的药登记被获得。所有数据用社会科学统计套装软体 11.5 被分析。结果作为象频率(百分比) 那样的描述的索引被报导。Chisquare 测试有关教育水平和年龄被用于数据。不到 0.05 被认为 significant.ResultsIn 的 P 价值提及的时期, 1 831 个人被打死,从谁 un/lowly 教育了人(69.6%) 说明了最高的死亡率。在教育水平和死亡率之间的重要关系被发现(X 2=275.98, P < 0.0001 ) 。另外三是在年龄和死亡率之间的一个重要协会(X 2=371.20, P < 0.0001 ) 。年轻人(在 20 和 29 年之间的年龄) 与另外的年龄 groups.ConclusionThe 相比贡献更高的 RTA 死亡率教育水平和年龄显著地被相关到死亡率。青春和 un/lowly 教育了人承受更多的致命的 RTA。 | Ashkan Sami Ghasem Moafian Arman Najafi Mohammad Reza Aghabeig Navid Yamin Seyed Taghi Heydari Kamran B Lankarani | 2013 | Chinese Journal of Traumatology2013，16，5： | 2 |
| 9 | An epidemiologic survey of road traffic accidents in Iran: analysis of driver-related factors显示文摘ObjectiveRoad 交通事故(RTA ) 和它的相关损害在伊朗贡献疾病的负担的重要部分。这份报纸在 countryMethodsThis 探索在司机相关的因素和 RTA 之间的协会代表性的学习从 2010 年 3 月 20 日关于 RTA 在伊朗和所有数据被进行到 2010 年 6 月 10 日从交通警察部门被获得。我们包括了 538 588 RTA 记录,它被分类为主要 confounders 控制:事故类型,事故的最后的原因,事故的时间和司机相关的因素。司机相关的因素包括了性,教育水平,许可证类型,损害的类型,在事故之间的持续时间并且得到驾驶执照和 538 588 位司机的 driver’s 错误 type.ResultsA 总数(91.83% 男性,几乎 13:1 的性比率) 涉及 RTA。在他们之中 423 (78.71%) 932 是未受损伤的;224 (41.74%) 818 有证书度。等级 2 驾驶执照代表了所有驾驶执照的最高的比例(290 811, 54.00%) 。事故的最大的数字发生在 12:00-13:59 (75 024, 13.93%) 。涉及 RTA 的司机的比例在在 10 以后得到一个驾驶执照到 3.13% 的第一年里从 15.90% 减少了; years’驾驶经验。规定的疏忽是交通碰撞的最普通的原因(345 589, 64.17%) 。到前面的优先级和疏忽的违反是死亡的最经常的最后的原因(138 175, 25.66% 和 129 352, 24.02% ,分别地) 。我们发现了在事故和性的类型之间的重要协会,教育,许可证类型,事故的时间,事故的最后的原因,在事故之间的 driver’s 错误以及持续时间并且得到驾驶执照(所有 P ;< ; 0.001 ) .ConclusionOur 结果将改进交通法律实施措施,它将改变司机的不恰当的行为并且保护最不富有经验的道路用户。 | Ghasem Moafian Mohammad Reza Aghabeigi Seyed Taghi Heydari Amin Hoseinzadeh Kamran Bagheri Lankarani Yaser Sarikhani | 2013 | Chinese Journal of Traumatology2013，16，3： | 2 |
| 10 | A contact force model with hysteresis damping for impact analysis of multibody systems 显示文摘 | Lankarani H M Nikravesh P E | 1990 | Journal of Mechanical Design (S 1050-0472)1990，112，： | 1 |
| 11 | Evaluation of insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome显示文摘 | Lankarani M Valizadeh N Heshrnat R | 2009 | Gynecol Endocrinol2009，25，8： | 1 |
| 12 | Impact analysis of plates using quasi-static approach显示文摘 | Shivaswamy S Lankarani H M | 1997 | J Mech Des1997，119，： | 1 |
| 13 | A contact force model with hysteresis damping for impact analysis of multibody systems 显示文摘 | Lankarani H M Nikravesh P E | 1990 | Journal of Mechanical Design1990，112，3： | 1 |
| 14 | Contact force model with hysteresis damping for impact analysis of multibody systems 显示文摘 | Lankarani H M Nikravesh P E | 1990 | Journal of Mechanisms Transmissions and Automation in Design1990，112，3： | 1 |
| 15 | Dynamics of multibody systems with spherical clear- ance joints显示文摘 | P Flores J Ambr6io J C P Claro H M Lankarani | 2006 | Journal of Computational and Non- linear Dynamics2006，1，： | 1 |
| 16 | Continuous contact force modes for impact analysis in multi-body systems显示文摘 | Lankarani H M Nikravesh P E | 1994 | Nonlinear Dynamics1994，5，2： | 1 |
| 17 | A contact force model with hysteresis damping for impact analysis of muhibody systems 显示文摘 | Lankarani H M Nikravesh P E | 1990 | Journal of Mechanical Design1990，112，3： | 1 |
| 18 | Castleman's Disease of the Porta Hepatis显示文摘 | Geramizadeh B Fattahi MR Bagheri Lankarani K | 2012 | Middle East J Dig Dis2012，4，： | 1 |
| 19 | A contact force model with hysteresis damping for impact analysis of multibody systems 显示文摘 | LANKARANI H M NIKRAVESH P E | 1990 | Journal of Mechanical Design(AMSE)1990，112，3： | 1 |
| 20 | A contact force model with hysteresis da- mping for impact anslysis of multibody systems显示文摘 | ] Lankarani H M Nikravesh P E | 1990 | Journal of Mechanical Design(S1050-0472)1990，，112： | 1 |
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