|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia显示文摘 | Lantu Gou Mingde Fu Yanhua Xu Ying Tian Bingyu Yan Luchuan Yang | 2005 | American Heart Journal2005，，5： | 1 |
| 2 | Telomerase expression in lung preneoplasia and neoplasia显示文摘 | Lantu e joul S Salon C Soria JC Brambilla g | 2007 | Int J Cancer2007，120，9： | 1 |
| 3 | Pulmonary venoocclusive disease and pulmonary capillary hemangiomatosis:a clinicopathologic study of 35 cases显示文摘 | Lantuéjoul S Sheppard MN Corrin B | 2006 | Am J Surg Pathol2006，30，7： | 1 |
| 4 | Inertialconfinementfusionneutronimages显示文摘 | DisdierL RouyerA LantuéjoulI etal | 2006 | PhysPlasmas2006，13，05： | 1 |
| 5 | Use of watersheds in contour detection显示文摘 | BEUCHER S LANTU JOUL C | 1979 | Pattern Recognition1979，21，5： | 1 |
| 6 | 查看详情显示文摘 | Disdier L Rouyer A Lantuéjoul I | | 0，，： | 1 |
| 7 | Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia显示文摘 | Lianqun Jia Mingde Fu Ying Tian Yanhua Xu Lantu Gou Haoming Tian Li Tian | 2006 | International Journal of Cardiology2006，，3： | 1 |
| 8 | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling显示文摘 | Xiangzheng Chen Yangping Wu Yangfu Jiang Yan Zhou Yuxi Wang Yuqin Yao Cheng Yi Lantu Gou Jinliang Yang | 2012 | Journal of Molecular Medicine2012，，11： | 1 |
| 9 | Inertial confinement fusion neutron images显示文摘 | Disdier L Rouyer A Lantuéjoul I | 2006 | Phys Plasmas2006，13，05： | 1 |
| 10 | A novel pro- apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice显示文摘 | YAN Fei GOU Lantu YANG Jinliang | 2009 | Biochimie2009，91，4： | 1 |
| 11 | Inertial confinement fusion neutron images显示文摘 | Disdier L Rouyer A Lantuéjoul I | 2006 | Physics of Plasmas2006，13，05： | 1 |
| 12 | Antibody-drug conjugates:Recent advances in payloads显示文摘Antibody-drug conjugates(ADCs),which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing,show great clinical therapeutic value.The ADCs’payloads play a key role in determining the efficacy of ADC drugs and thus have attracted great attention in the field.An ideal ADC payload should possess sufficient toxicity,low immunogenicity,high stability,and modifiable functional groups.Common ADC payloads include tubulin inhibitors and DNA damaging agents,with tubulin inhibitors accounting for more than half of the ADC drugs in clinical development.However,due to clinical limitations of traditional ADC payloads,such as inadequate efficacy and the development of acquired drug resistance,novel highly efficient payloads with diverse targets and reduced side effects are being developed.This perspective summarizes the recent research advances of traditional and novel ADC payloads with main focuses on the structure-activity relationship studies,co-crystal structures,and designing strategies,and further discusses the future research directions of ADC payloads.This review also aims to provide valuable references and future directions for the development of novel ADC payloads that will have high efficacy,low toxicity,adequate stability,and abilities to overcome drug resistance. | Zhijia Wang Hanxuan Li Lantu Gou Wei Li Yuxi Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 13 | ALK阳性非小细胞肺癌的细胞异质性的技术因素分析——非生物学解释显示文摘2007年在肺腺癌一个小亚群中发现的间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)基因重排界定了一类新的非小细胞肺癌(non-small-cellcarcinoma,NSCLC)分子亚型[1]。这些ALK-重排的肿瘤中腺癌最常见,经常可见印戒黏液细胞,无表皮生长因子受体(EGFR)或结直肠癌基因——K R A S突变,更多出现于不吸烟或轻度吸烟患者中,但一些ALK-重排的NSCLC不符合以上描述。目前已确定多种基因融合变异;最常见的为2号染色体短臂发生倒位形成的EML4-ALK基因融合。 | Anne McLeer-Florin Sylvie Lantuéjoul 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，3： | 0 |
| 14 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 15 | On the Same Origin of Legal Compulsoriness and the Compulsoriness of Legal Discourse显示文摘It’s been about half a decade since Michel Foucault delivered his famous inaugural lecture “Orders of Discourse”. Descriptive research into legal discourse, however, still predominates over the exploration of the hidden power relationship. This article aims to apply Foucault’s insights into discourse to the field of law and further shed light on the in-depth interactive mechanism of power and discourse. By investigating how legal norms were legitimized from the very beginning, it’s found that the legal compulsoriness and the compulsoriness of legal discourse are of the same origin. | XIAO Peng LI Lantu | 2019 | Journal of Philosophy Study2019，9，8： | 0 |
| 16 | Chemokine Ligand 13 Expression is Abundant in the Tumor Microenvironment and Indicates Poor Prognosis of Kidney Clear Cell Carcinoma显示文摘The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma(KIRC)and its correlation with tumor-infiltrating immune cells(TIICs).A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry(IHC).Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas(TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB.Results showed that high CXCL13 expression in TME was associated with shorter progression-free survival(PFS),disease-specific survival(DSS),and overall survival(OS).KIRC cell lines,as well as several other cancer cell lines,had negative CXCL13 expression.IHC staining from the Human Protein Atlas(HPA)and our tissue array indicated that CXCL13 might be mainly expressed by TIICs,but not KIRC tumor cells.CXCL13 expression was strongly and positively correlated withγδT cell abundance in TME.Besides,γδT cell infiltration was associated with poor survival of KIRC.Methylation 450k array data showed that CXCL13 promoter hypomethylation was common in TIICs.The methylation level of cg16361705 within the CXCL13 promoter might play an important role in modulating CXCL13 transcription.In conclusion,our study revealed that CXCL13 expression andγδT cell infiltration in TME is associated with unfavorable survival of KIRC.TIICs,most possiblyγδT cells,are the dominant source of CXCL13 in KIRC TME. | MENGDAN WU MENGYAO SUN QINHUAI LAI YIN LU YUYIN FU YUJIA PENG WEIRONG LAI LISHI ZENG SHENGYAN ZHAO YUYAN LI ZHIXIONG ZHANG XIAOFENG CHEN FAN QIAO YIWEN ZHANG SHIJIE ZHOU LANTU GOU JINLIANG YANG | 2021 | BIOCELL2021，45，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员