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| 1 | ERK1/2通路参与ET_A和ET_B受体介导的离体肠系膜上动脉收缩研究显示文摘目的探讨细胞外信号调节激酶1/2(ERK1/2)信号转导通路在内皮素1(ET-1)的两个G蛋白偶联受体ET_A和ET_B介导的收缩机制。方法用大鼠肠系膜上动脉器官培养模型,以敏感的离体药理学实验方法记录培养前后血管平滑肌张力,实时定量的PCR测定培养前后受体mRNA表达水平的变化。结果S6c不引起新鲜的肠系膜上动脉收缩,培养后ETB受体mRNA表达水平上调,介导的收缩明显增强(P<005);而ETA受体介导的收缩功能和mRNA均变化不大。低浓度的SB386023(10-5mol·L-1)降低S6c引起的最大收缩(Emax从239%±26%降至89%±13%,P<001),而对ET1引起的最大收缩并无影响(Emax271%±19%vs251%±16%,P>005);高浓度的SB386023(10-4mol·L-1)明显抑制ETA受体介导的收缩。结论ET-1通过ET_A受体介导新鲜动脉的收缩;动脉培养后表达ET_B受体;ERK1/2信号转导通路对ET_B受体的作用强于ET_A受体。 | 罗国刚 马爱群 徐仓宝 曹永孝 Lars Edvinsson | 2005 | 中国药理学通报2005，21，3： | 14 |
| 2 | ALTERATION IN CONTRACTILE RESPONSE TO NORADRENALINE, 5-HYDROXYTRYPTAMINE, S ARAFOTOXIN 6c, AND ANGIOTENSINⅡ IN RAT MESENTERIC ARTERY DURING ORGAN CULTURE显示文摘Objective To compare the vasoconstrictive eff ects of 9 mediators on fresh and incubated mesenteric arteries of rats. Methods The superior mesenteric artery of rat was removed and t he endothelium was denuded. The vessels were cut into 1 mm long cylindrical segm ents and subjected to organ culture for 24 hours. Fresh or incubated segments we re immersed into tissue baths and the concentration-response curves were obtain ed by cumulative administration of the vasoconstrictors. Results In fresh mesenteric artery, endothelin-1 (ET-1), 5-h ydroxytryptamine (5-HT), noradrenaline (NA), 5-carboxamidotryptamine (5-CT), and angiotensinⅡ (AngⅡ) induced potent and sustained constrictions in a concen tration-dependent manner. The contraction induced by sarafotoxin 6c (S6c) was w eak, while bradykinin (BK), des-Arg-bradykinin (DA-BK), and human urotensinⅡ (hUT-II) showed no detectable contraction. The concentraion-response curves i n order of slopes was ET-1, NA, 5-HT, 5-CT, and AngⅡ. The order of the maxim um contractions was ET-1>NA=5-HT=5-CT>AngⅡ>S6c. After organ culture, the con centration-response curves induced by S6c, NA, and 5-HT were significantly inc reased, while that induced by AngⅡ was decreased as comparing to fresh arteries . BK contracted the artery only weakly. Conclusion Organ culture changed the phenotypes towards an increased efficacy of NA, 5-HT, S6c, and a reduced efficacy of AngⅡ, which is in accordance with the results o f pharmacological characterization in some human vascular disease. | 曹永孝 贺浪冲 徐仓宝 EDVINSSON Lars | 2004 | Journal of Pharmaceutical Analysis2004，16，2： | 8 |
| 3 | 阿托品对大鼠肠系膜动脉的舒张作用及机制显示文摘目的 研究阿托品的扩血管作用及机制。方法 以大鼠肠系膜动脉为标本,考察阿托品对去甲肾上腺素(NE)预收缩血管的舒张作用以及血管内皮细胞、血管平滑肌在该效应中的作用。结果 阿托品能显著舒张NE预收缩的完整内皮血管,去内皮后该作用明显降低。L Nω硝基精氨酸甲酯、吲哚美辛、普萘洛尔及格列本脲对阿托品的舒张作用无明显影响。阿托品对KCl的量效曲线及咖啡因缩血管作用均无明显影响,但能浓度依赖性地抑制NE诱导的内钙释放以及经受体操纵性钙通道的外钙内流。结论 阿托品有明显的扩血管作用,其通过抑制受体介导的外钙内流和内钙释放而舒张血管。 | 郑建普 曹永孝 徐仓宝 Lars Edvinsson | 2005 | 药学学报2005，40，5： | 5 |
| 4 | Brain natriuretic peptide is a potent vasodilator in aged human microcircula- tion and shows a blunted response in heart failure patients显示文摘BackgroundBrain natriuretic 肽(BNP ) 在在发行量的底层是通常在场的,但是它在心失败题目(CHF ) 与拥挤的度同时被提高。BNP 有 natriuretic 效果并且是有势力血管扩张药。BNP 能是在 CHF 的一种治疗学的选择,这被建议。然而,我们要求了在 CHF 的传播 BNP 的高水平可以 downregulate microvascular natriuretic 受体的反应。这被比较 15 个 CHF 病人测试(BNP >3000 ng/L ) 与 10 匹配的、健康 controls.MethodsCutaneous microvascular 血,在前臂的流动被激光 Doppler Flowmetry 测量。本地加热(+44 ° C, 10 min ) 被用来唤起一个最大的本地扩张器 BNP 或醋胆素(ACh ) 的 response.ResultsNon 侵略的 iontophoretic 管理,一个已知的内皮细胞层依赖者扩张器,在本地流动得到了增加。氮的氧化物 synthase 禁止者, l-N-Arginine- 甲基酉旨(L 名字) ,堵住了 BNP 反应(在控制) 。有趣地,对在 CHF 病人的 BNP 的回答被归结为在健康控制看见的大约三分之一那些(的增加流动:251% 在 CHF 对 908% 在控制;P <0.001 ) 。相反,对 ACh 并且到本地加热的血管扩张药回答仅仅有点在 CHF 病人被稀释。因此,发信号的扩张器能力和氮的氧化物没被影响到象调停 BNP 的膨胀的一样的程度,第一次显示后者 response.ConclusionsThe 调查结果表演的特定的 downregulation 对 BNP 的 microvascular 回答显著地在 CHF 病人被减少。这与 BNP 受体功能的假设一致是在 CHF 的 downregulated。 | Marie-Louise Edvinsson Erik Uddman Lars Edvinsson Sven E. Andersson | 2014 | Journal of Geriatric Cardiology2014，11，1： | 5 |
| 5 | Hospital utilization and costs for spinal cord stimulation compared with enhanced external counterpulsation for refractory angina pectoris显示文摘 | Susanne M. Bondesson Ulf Jakobsson Lars Edvinsson Ingalill Rahm Hallberg | 2011 | Journal of Evaluation in Clinical Practice2011，，： | 2 |
| 6 | Treatment ofmigraine attacks based on the interaction with the trigemino-cerebro-vascular system显示文摘 | Andrea Stephanie Link Aniko Kuris Lars Edvinsson | 2008 | Headache Pain2008，9，1： | 1 |
| 7 | Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system显示文摘 | Andrea Stephanie Link Anikó Kuris and Lars Edvinsson | 2008 | Headache Pain2008，9，1： | 1 |
| 8 | Cerebral Ischemia Upregulates Vascular Endothelin ETB Receptors in Rat显示文摘 | Emelie Stenman Malin Malmsj? Erik Uddman Gunilla Gid? Tadeuz Wieloch Lars Edvinsson | 2002 | Stroke: Journal of the American Heart Association2002，，9： | 1 |
| 9 | Treatmentof migraine attacks based on the interaction with the trigeminoce-rebro-vascular system显示文摘 | Andrea Stephanie Link Aniko Kuris and Lars Edvinsson | 2008 | Headache Pain2008，9，1： | 1 |
| 10 | Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries显示文摘 | Steffen Birk Lars Edvinsson Jes Olesen Christina Kruuse | 2004 | European Journal of Pharmacology2004，，1： | 1 |
| 11 | Basic mechanisms of migraine and its acute treatment显示文摘 | Lars Edvinsson Carlos M. Villalón Antoinette MaassenVanDenBrink | 2012 | Pharmacology and Therapeutics2012，，3： | 1 |
| 12 | Apolipoprotein B of low-density lipoprotein impairs nitric oxide-mediated endothelium-dependent relaxation in rat mesenteric arteries显示文摘 | Yaping Zhang Wei Zhang Lars Edvinsson Cang-Bao Xu | 2014 | European Journal of Pharmacology2014，，： | 1 |
| 13 | Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression显示文摘 | Cang-Bao Xu Jian-Pu Zheng Wei Zhang Enqi Liu Lars Edvinsson Yaping Zhang | 2013 | Vascular Pharmacology2013，，： | 1 |
| 14 | Cardiovascular risk factors regulate the expression of vascular endothelin receptors显示文摘 | Cang-Bao Xu Yang Sun Lars Edvinsson | 2010 | Pharmacology and Therapeutics2010，，2： | 1 |
| 15 | Aspect on the pathophysiology of migraine and cluster headache 显示文摘 | Lars Edvinsson | 2001 | Pharmacology & Toxicology2001，89，： | 1 |
| 16 | Treatment of migraine attacks based on the interaction with the trigemino - cerebrovascular system 显示文摘 | Lars Edvinsson | 2008 | J Headache Pain2008，9，： | 1 |
| 17 | Aspect on the pathophysiology ofmigraine and clusterheadache显示文摘 | Lars Edvinsson | 2001 | Pharmacology & Toxicology2001，89，： | 1 |
| 18 | Reduced peripheral vascular reactivity in refractory angina pectoris:Effect of enhanced external counterpulsation显示文摘Objective To examine if the skin microvascular bed is altered and can be modified by enhanced external counterpulsation(EECP)in patients with chronic refractory angina.Methods Twenty patients diagnosed with refractory angina were divided into EECP(n=10)or no EECP(n=10)groups.The data were compared to matched healthy subjects(n=20).The cutaneous forearm microvascular blood flow was measured by Laser-Doppler flowmetry.The vascular responsiveness to iontophoretic administration of acetylcholine(ACh),sodium nitroprusside(SNP)and local skin warming were studied.Measurements of Canadian Cardiovascular Society(CCS)-class,blood pressure and plasma samples were registered.Results EECP patients showed reduced CCS-class compared to no EECP(P<0.05).Both EECP and no EECP(P<0.05)groups had decreased systolic blood pressure(SBP)as compared to SBP at baseline(P<0.05).There was no difference in resting blood flow between the two refractory groups at baseline as well as after EECP and seven weeks of follow-up.Responses to heating,the responses to ACh and SNP in the cutaneous microcirculation were lower in both groups of refractory angina patients as compared to healthy subjects(P<0.05).EECP patients corresponded positively to the treatment shown by reduced plasma level of soluble interleukin-2 receptor and CCS-class.Conclusions Refractory angina patients have reduced responsiveness in their cutaneous microcirculation to ACh,SNP and heat compared to healthy subjects.Although EECP reduced the CCS-class,this effect was not associated with improvements in responsiveness of the cutaneous microcirculation. | Susanne M Bondesson Marie-Louise Edvinsson Thomas Pettersson Lars Edvinsson | 2011 | Journal of Geriatric Cardiology2011，8，4： | 0 |
| 19 | Increased mortality in elderly heart failure patients receiving infusion of furosemide compared to elderly heart failure patients receiving bolus injection显示文摘Heart failure(HF)is a condition of cardiac dysfunction and fluid overload.Neurohormonal activation via the reninangiotensin-aldosterone system and the sympathetic nervous system are the pathophysiological cornerstones.[1]Furthermore,HF is a disorder widely associated with grave adverse outcomes and poor prognosis.[2]A loop diuretic is the fundamental drug used to prevent multiorgan failure and improve symptoms in these patients.[3] | Rana Sager Isak Lindstedt Lars Edvinsson Marie-Louise Edvinsson | 2020 | Journal of Geriatric Cardiology2020，17，6： | 0 |
| 20 | CGRP受体拮抗剂治疗偏头痛显示文摘在近期Lancet上,Ho及其同事发表了新型口服的降钙素基因相关肽(CGRP)受体拮抗剂telcagepant与目前最有效的药物阿米替林、佐米曲普坦和安慰剂进行对比的第一阶段Ⅲ期试验。该药物通过一种新的抗偏头痛机制发挥作用,即阻断CGRP在CGRP受体复合物中的作用。在该研究中,telcagepant与佐米曲普坦相比抗偏头痛作用无显著差异,但前者副作用较少。虽然许多科学问题仍有待解决,但其结果却为偏头痛的治疗提供了新的选择。 | Lars Edvinsson | 2009 | 世界临床医学2009，，8： | 0 |
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