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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Nurse workingconditions,organizational climate,and intent to leave in ICUs : aninstrumental variable approach part I显示文摘 | Stone P Mooney-Kane C Larson E | 2007 | Health Serv Hes2007，42，3： | 1 |
| 3 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998，112，2： | 1 |
| 4 | Most apparent distortion:full-reference image quality assessment and therole of strategy显示文摘 | Larson E C Chandler D M | 2010 | Journal of Electronic Imaging2010，19，1： | 1 |
| 5 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
| 6 | Estimating soil water retention characteristics from particle size distribution organic matter percent, and bulk density显示文摘 | GUPTA S C LARSON W E | 1979 | Water Resources Research1979，15，6： | 1 |
| 7 | NCSOIL, a model of nitrogen and carbon transformation in soil: Description, calibration, and behavior显示文摘 | Moiina j A E Clapp C E Shaffer M J Chichester F W Larson W E | 1983 | Soil Science Society of America Journal1983，47，1： | 1 |
| 8 | Economic scales for firslngener- ation biomass-gasifier/gas turbine combined cycles fueled from energy plantations显示文摘 | Larson E D Marrison C I | 1997 | Journal of Engineering for Gas Turbines and Power1997，119，2： | 1 |
| 9 | Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate显示文摘 | Schilmiller A.L Schauvinhold I Larson M Xu R Charbonneau A.L Schmidt A Wilkerson C Last R.L and Pichersky E | | 0，，： | 1 |
| 10 | Soil tempera-ture and the early growth of corn from mulched and unmulched soil显示文摘 | VAN WIJK W R LARSON W E BURROWS W C | 1959 | Soil Science Society of America Journal1959，23，6： | 1 |
| 11 | Water quality modeling of the upper Mississippi River and Lake Pepin显示文摘 | Lung W S Larson C E | 1995 | J Environ Eng1995，121，20： | 1 |
| 12 | Three-dimensional X-ray structural microscopy with submicrometre resolution 显示文摘 | LARSON B C YANG W ICE G E BUDAI J D TISCHLER J Z | 2002 | Nature2002，415，6874： | 1 |
| 13 | Project Management: The Managerial Process with MS Project显示文摘 | Kim Larson E W Gray C F | 2014 | 2014，，： | 1 |
| 14 | Understanding vaccine hesitancy around vaccines and vaccination from a global perspec- tive : A systematic review of published literature, 2007-2012 显示文摘 | Larson HJ Jarrett C Eckersberger E et at | 2014 | Vaccine2014，32，19： | 1 |
| 15 | Generation and mapping of expressed sequence tags from virus- injected swine macrophages 显示文摘 | Wang C Hawken RJ Larson E Zhang X Alexander L Rutherford MS | 2001 | Anim Biotechnol2001，12，1： | 1 |
| 16 | A broadband 10 GHz track-and-hold in Si/SiGe HBT technology 显示文摘 | Jonathan C Jensen Lawrence E Larson | 2001 | IEEE Journal of Solid-state Circuits2001，36，3： | 1 |
| 17 | Medicinal chemistry of aldose reductase inhibitors 显示文摘 | Larson E R Lipinski C A Sarges R | 1988 | Med Res Rev1988，8，： | 1 |
| 18 | Most apparent distortion: full-reference image quality assessment and the role of strategy显示文摘 | LARSON E C CHANDLER D M | 2010 | Journal of Electronic Imaging2010，19，01： | 1 |
| 19 | Estimating soil water retention characteristics from particle size distribution, organic matter percent, and bulk density 显示文摘 | GUPTA S C LARSON W E | 1979 | Water Resources Research1979，15，6： | 1 |
| 20 | Predictors of new - onset kidney disease in a communitybased population显示文摘 | FOX C S LARSON M G LEIP E P | 2004 | JAMA2004，291，7： | 1 |
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