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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 3 | Processing aspects of the space shuttle orbiter's ceramic reusable surface insu- lation显示文摘 | Banas R P Gzowski E R Larson W L | 1983 | Ceram Eng Sci Proc1983，4，78： | 1 |
| 4 | Rebound of five one-dimensionally compressed unsaturated granular soils显示文摘 | STONE J A LARSON W E | 1980 | Soil Science Society of America Journal1980，44，4： | 1 |
| 5 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
| 6 | Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly populationfrom Seattle显示文摘 | OLSEN G W CHURCH T R LARSON E B | 2004 | Washington Chemosphere2004，54，： | 1 |
| 7 | Corn growth as affected by soil temperature and mulch显示文摘 | Willis W O Larson W E Kirkham D | 1957 | Agronomy Journal1957，49，： | 1 |
| 8 | Estimating soil water retention characteristics from particle size distribution organic matter percent, and bulk density显示文摘 | GUPTA S C LARSON W E | 1979 | Water Resources Research1979，15，6： | 1 |
| 9 | NCSOIL, a model of nitrogen and carbon transformation in soil: Description, calibration, and behavior显示文摘 | Moiina j A E Clapp C E Shaffer M J Chichester F W Larson W E | 1983 | Soil Science Society of America Journal1983，47，1： | 1 |
| 10 | Changes in microrelief and their effects on infiltration and erosion during simulated rainfall显示文摘 | Magunda M K Larson W E Linden D R | 1997 | Soil Technology1997，10，1： | 1 |
| 11 | The threat of soil erosion to long-term crop production显示文摘 | Larson W E Pierce F J Dowdy R H | 1983 | Science1983，219，9： | 1 |
| 12 | Denitrification of wastewater influents with methane显示文摘 | Sollo F W Mueller H F Larson T E | 1976 | Journal of Water Pollution Control Fed1976，48，7： | 1 |
| 13 | Soil tempera-ture and the early growth of corn from mulched and unmulched soil显示文摘 | VAN WIJK W R LARSON W E BURROWS W C | 1959 | Soil Science Society of America Journal1959，23，6： | 1 |
| 14 | Productivity of soils: assessing long term changes due to erosion' s long term effects显示文摘 | PIERCE F J LARSON W E DOWDY R H | 1983 | Journal of Soil and Water Conservation1983，38，： | 1 |
| 15 | A digital calibration method for synthetic aperture radar systems显示文摘 | LARSON R W JACKSON P L KASISCHKE E S | 1988 | IEEE Trans Geosei Remote Sensing1988，26，： | 1 |
| 16 | A reputation mechanism for layered communities显示文摘 | Fourquet E Larson K Cowan W | 2006 | ACM SIGECOM Exchanges2006，6，1： | 1 |
| 17 | The dynamics of soil quality as a measure of sustainable management显示文摘 | Larson W E Pierce F J | 1994 | 35:37-511994，35，： | 1 |
| 18 | A digital calibration method for synthetic aperture radar systems 显示文摘 | LARSON R W JACKSON P L KASISCHKE E S | 1988 | IEEE Transactions on Geoscience and Remote Sensing1988，26，6： | 1 |
| 19 | Precise nanometer localization analysis for individual fluorescent probes显示文摘 | Thompson R E Larson D R Webb W W | 2002 | Biophysical Journal2002，82，5： | 1 |
| 20 | Water quality modeling of the upper Mississippi River and Lake Pepin显示文摘 | Lung W S Larson C E | 1995 | J Environ Eng1995，121，20： | 1 |
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