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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 3 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996，275，20： | 1 |
| 4 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 5 | Amelioration of ischemia- reperfusion injury with cyclic peptide blockade of ICAM-1 显示文摘 | Merchant S Gurule D Larson R | 2003 | Am J Physiol Heart Circ Physiol2003，284，4： | 1 |
| 6 | Long-term trends in the incidence of and survival with heart failure显示文摘 | LEVY D KENCHAIAH S LARSON M G | 2002 | N Engl J Med2002，347，18： | 1 |
| 7 | Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to longdistance transfers显示文摘 | Larson D M Duval S Sharkey S W | 2012 | Eur Heart J2012，33，10： | 1 |
| 8 | Long-term trends in the in- cidence and survival with heart faihtre 显示文摘 | Levy D Kenehaiah S Larson MG | 2002 | N Engl J Med2002，347，18： | 1 |
| 9 | Traumatic intracranial aneurysms显示文摘 | Larson P S Reisner A Morassutti D J | | 0，，01： | 1 |
| 10 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 11 | lncreased incidence of well-differentiated thyroid cancer associated with Hashimoto's thyroiditis and the role of the PI3K/AKT pathway显示文摘 | Larson S D Jackson L Riall T | 2007 | J Am Coil Surg2007，204，5： | 1 |
| 12 | Tea tree oil 显示文摘 | LARSON D JACOB S E | 2012 | Dermatitis2012，23，1： | 1 |
| 13 | Long-term trends in the incidence of and survival with heart failure显示文摘 | Levy D Kenchaiah S Larson MG | 2002 | N Engl J Med2002，347，18： | 1 |
| 14 | The roter interaction analysis system: Utility and flexibility for analysis of medical interactions显示文摘 | Roter D Larson S | 2002 | Patient Education and Counselling2002，46，4： | 1 |
| 15 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
| 16 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
| 17 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 18 | Design principles for multicuhannel fringing electric field sensors显示文摘 | Li Xiaobei B Larson Sam D Zyuzin Alexei S | 2006 | IEEE Sensors Journal2006，6，2： | 1 |
| 19 | 美国髋膝关节置换患者有多少?显示文摘越来越多的个人生活与髋膝关节置换密切相关。作者对美国的髋膝关节置换情况做了流行病学调查,从美国国家出院调查和医疗成本数据库中调取了1969-2010年的数据,并加以分析。结果发现,行髋、膝关节置换的患者分别占总人口的0.83%和1.52%,女性高于男性;80岁以上人群中,行髋、膝关节置换的患者分别占到10.38%和5.26%;且发病率趋向年轻化。 | Maradit Kremers H Larson D R Crowson C S 李军 | 2015 | 临床骨科杂志2015，18，6： | 1 |
| 20 | Benefits and risks of tight glucose control in critically ill adults:A meta-a- nalysis显示文摘 | Wiener R S Wiener D C Larson R J | 2008 | JAMA2008，300，8： | 1 |
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