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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Systemic inflammation and copd: the framing, ham heart study 显示文摘 | Walter R E Wilk J B Larson M G | 2008 | Chest2008，133，1： | 1 |
| 3 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 4 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 5 | Granulocyte-macrophage colony stimulating factor-induced immune priming of cyclophosphamide,doxorubicin,vincristine,and prednisone with rituximab chemoimmunotherapy in previously untreated patients with diffuse large B-cell lymphoma and mantle cell lympho显示文摘 | Karmali R Larson M L Wooldridge J E | | 0，，11： | 1 |
| 6 | Effect of surfactant layers on the size changes of aerosol particles as a function of relative humidity显示文摘 | ANDREWS E LARSON S M | 1993 | Envi- ronmental Science & Technology1993，27，5： | 1 |
| 7 | Impact of glucose intolerance and insulin resistance on cardiac structure and function显示文摘 | KUTTER M K BENJAMIN E J LARSON | 2003 | Circulation2003，107，3： | 1 |
| 8 | Most apparent distortion:full-reference image quality assessment and therole of strategy显示文摘 | Larson E C Chandler D M | 2010 | Journal of Electronic Imaging2010，19，1： | 1 |
| 9 | Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research显示文摘 | Liang M H Larson M G Cullen K E | 1987 | Arthritis Rheum1987，28，5： | 1 |
| 10 | Microarray analysis of diurnal and circadian-regulated genes in Arabidopsis显示文摘 | Schaffer R Landgraf J Accerbi M Simon V Larson M Wisman E | | 0，，： | 1 |
| 11 | Impact of high - normal blood pressure on the risk of cardiovascular disease 显示文摘 | Vasari R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
| 12 | Calcium carbonate saturation index and alkalinity interpretations 显示文摘 | LARSON T E BUSWELL A M | 1942 | Journal of American Water Works Association1942，34，11： | 1 |
| 13 | Deratofibrosarcoma protuberans:a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature显示文摘 | Snow S N Gordon E M Larson P O | 2004 | Cancer2004，101，1： | 1 |
| 14 | Assessment of attitudes of intensive care unit staff toward clinical practice guider lines显示文摘 | Pogorzelska M Larson E L | 2008 | Dimens Crit Care Nurs2008，27，1： | 1 |
| 15 | Impact of high normal blood pressure on the risk of cardiovascular disease显示文摘 | Vasan R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
| 16 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
| 17 | NCSOIL, a model of nitrogen and carbon transformation in soil: Description, calibration, and behavior显示文摘 | Moiina j A E Clapp C E Shaffer M J Chichester F W Larson W E | 1983 | Soil Science Society of America Journal1983，47，1： | 1 |
| 18 | Changes in microrelief and their effects on infiltration and erosion during simulated rainfall显示文摘 | Magunda M K Larson W E Linden D R | 1997 | Soil Technology1997，10，1： | 1 |
| 19 | Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate显示文摘 | Schilmiller A.L Schauvinhold I Larson M Xu R Charbonneau A.L Schmidt A Wilkerson C Last R.L and Pichersky E | | 0，，： | 1 |
| 20 | Impact of High-Normal blood pressure on the risk of cardiovascular disease显示文摘 | Vasan R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
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