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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Theisolation of structural genes from libraries of eucaryotic DNA显示文摘 | Maniatis T Hardison R C Lacy Lauer J O Connell C | | Cell0，15，： | 1 |
| 3 | Dynamic site index equation for thinned stands of even-aged natural longleaf pine 显示文摘 | Lauer D K Kush J S | 2010 | Southern Journal of Applied Forestry2010，34，1： | 1 |
| 4 | Left ventricular hypertrophy, the next treatable, silent killer显示文摘 | GARDIN J M LAUER M S | 2004 | JAMA2004，292，19： | 1 |
| 5 | Situation Outlook Questionnaire: measure of the climate for creativity and change显示文摘 | Isaksen S G Lauer K J Ekvall G | 1999 | Psychological Report1999，85，： | 1 |
| 6 | Situational outlook questionnaire : a measure of the climate for creativity and change显示文摘 | Isaksen S G Lauer K J Ekvall G | 1999 | Psychological Reports1999，，85： | 1 |
| 7 | Impairments of the medial olivocochlear system increase the risk of noise-induced autory neuropathy in laboratory mice 显示文摘 | MAY B J LAUER A M ROOS M J | 2011 | Otology and neurotology2011，32，9： | 1 |
| 8 | Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration:Engineering cell-invasion characteristics显示文摘 | LUTOLF M P LAUER J L SCHMOEKEL H G | 2003 | Proc Natl Acad Sc USA2003，100，9： | 1 |
| 9 | Mossbauer studiesof FeCu thin films 显示文摘 | KEUNE W LAUER J WILLIAMSON D L | 1974 | Journal de Physique1974，35，47： | 1 |
| 10 | Construction,characterization,and use of two Listeria monocytogenes site-specific phage integration vectors显示文摘 | Lauer P Chow M Y N Loessner M J | 2002 | J Bacteriol2002，184，15： | 1 |
| 11 | The climate for creativity and change in teams 显示文摘 | ISAKSEN S G LAUER K J | 2002 | Creativity and Innovation Management2002，11，1： | 1 |
| 12 | Situational outlook questionnaire: A measure of the climate for creativity and change 显示文摘 | Isaksen S G Lauer K J Ekvall G | 1999 | Psychological Reports1999，85，2： | 1 |
| 13 | Low-dose synergistic immu- nosuppression of tdepen-dent antibody responses by polycyclic aromatic hydrocarbons and arsenic in C57BL/6J murine spleen eells显示文摘 | Li Q Lauer F T Liu K J | 2010 | Toxieol Appl Pharmacol2010，245，3： | 1 |
| 14 | Perceptions of the Best and Worst Climates for Creativity: Preliminary Validation Evidence for the Situational Outlook Questionnaire 显示文摘 | ISAKSEN S G LAUER K J EKVALL G | 2001 | Creativity Research Journal2001，13，： | 1 |
| 15 | Corpecipitation of microalgal biomass with calcium and phosphate ions显示文摘 | SUKENIK A SCHRODER W LAUER J | 1985 | Water Research1985，19，1： | 1 |
| 16 | Perceptions of the best and worst climates for creativity: Preliminary validation evidence for the situational outlook questionnaire 显示文摘 | Isaksen S G Lauer K J Ekvall G Britz A | 2001 | Creativity Research Journal2001，13，： | 1 |
| 17 | Complexe textile 13e partie显示文摘 | LAUER J 1988 | 1988 | Rossiniana1988，45，： | 1 |
| 18 | Identification of specific hemopexin - like domain residues that facilitate matrix met alloproteinase collagenolytic activity 显示文摘 | Lauer - Fields JL Chalmers M J Busby SA | 2009 | J Biol Chem2009，284，24： | 1 |
| 19 | et al Factors in uencing elevation of intracellular Ca 2+ in the MCF-10A hu- man mammary epithelial cell line by carcinogenic polycyclic aromatic hy- drocarbons 显示文摘 | TANNHEIMER SL LAUER FT LANE J | 1999 | Mol Carcinogen1999，25，： | 1 |
| 20 | Oppommities of biomass-derived' bio-oil' in European heat and power markets 显示文摘 | Bramer J G Lauer M Bridgwater A V | 2006 | Energy Policy2006，34，： | 1 |
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