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| 1 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 2 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 3 | Deeonvolution With a spatially-variant PSF显示文摘 | Tod R Lauer | 2002 | Proceedings of SPIE2002，4847，： | 1 |
| 4 | Role of family history and family testing in cardiovascular risk assessment显示文摘 | LAUER R M | 1999 | Am J Med1999，107，2： | 1 |
| 5 | Does childhood obesity track into adulthood 显示文摘 | Clarke W R R M Lauer | 1993 | Critical Reviews in Food Science & Nutrition1993，33，45： | 1 |
| 6 | Theisolation of structural genes from libraries of eucaryotic DNA显示文摘 | Maniatis T Hardison R C Lacy Lauer J O Connell C | | Cell0，15，： | 1 |
| 7 | Applications of cortical signals to neuroprosthetic control: A critical review显示文摘 | Lauer R T | 2000 | IEEE Transactions on Rehabilition Engineering2000，，8： | 1 |
| 8 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral arterial bypass assistance显示文摘 | Thiele H Lauer B Hambrecht R | 2001 | Circulation2001，104，： | 1 |
| 9 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral arterial bypass assistance显示文摘 | Thiele H Lauer B Hambrecht R | | 0，，： | 1 |
| 10 | Solu- tion of large scale optimal unit commitment problems显示文摘 | Lauer G S Sandell Jr N R Bertsekas N R | 1982 | IEEE Trans on power apparatus1982，101，1： | 1 |
| 11 | Hemodynamic contsequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1998 | Am J Kidney Dis1998，12，： | 1 |
| 12 | Apossible genetic source for chipping potatoes from 40 F storage显示文摘 | Lauer Shaw R | 1970 | Am Potato1970，47，： | 1 |
| 13 | Modulation of growth factor binding properties of alpha2-macroglobulin by enzyme therapy 显示文摘 | Lauer D Mailer R Cott C | 2001 | Cancer Chemother Pharmacol2001，，： | 1 |
| 14 | Application of a neuro-fuzzy network for gait event detection using electromyography in the child with cerebral palsy显示文摘 | LAUER R SMITH B BETZ R | 2005 | IEEE Transactions on Biomedical Engineering2005，52，9： | 1 |
| 15 | Association of chronotropic incompetence with echocardiographic ischemia and prognosis 显示文摘 | Lauer MS Mehta R Pashkow FJ | 1998 | J Am Coil Cardiol1998，32，： | 1 |
| 16 | Com-puter-aided 3-D 'mTc-DPD-SPECT reconstructionto assess mandibular invasion by intraoral squamouscell carcinoma: diagnostic improvement or not显示文摘 | Schimming R Juengling FD Lauer G | 2000 | JCraniomaxillofac Surg2000，28，6： | 1 |
| 17 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral atrial bypass assistance显示文摘 | Thiele H Lauer B Hambreeht R | 2001 | Circulation2001，104，： | 1 |
| 18 | Hemodynamic consequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1988 | Am J Kidney Dis1988，12，： | 1 |
| 19 | Cellular imnmne responses against hepatitis C virus:The evidence base 2002 显示文摘 | Ward S Lauer G Isba R | 2002 | Clin Exp Immunol2002，128，： | 1 |
| 20 | Association of smoking with abnormal exercise heart rate responses and long-term prognosis in a healthy,population-based cohort显示文摘 | Srivastava R Blackstone EH Lauer MS | 2000 | Am J Med2000，109，1： | 1 |
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