|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 3 | The role of root exudates in rhizosphere interactions with plants and other organisms显示文摘 | Harsh P B Tiffany L W Laura G P | 2006 | Plant Biology2006，57，： | 1 |
| 4 | Structurally tailored organic-inorganic perovskites: Optical properties and solution-processed channel material for thin-film transistors显示文摘 | David B Mitzi Christos D Dimitrakopoulos Laura L Kosbar | 2001 | Chem Mater2001，13，： | 1 |
| 5 | High resolutionFIB-TEM and FIB-SEM characterization of electrode/elec-trolyte interfaces in solid oxide fuel cells materials显示文摘 | Analia L Soldati Laura B Horacio T | 2011 | Inter-national Journal of Hydrogen Energy2011，，36： | 1 |
| 6 | Effect of culture parameters on the production of the edible mushroom Grifola frondosa (maitake) in tropical weathers显示文摘 | Sandra M B Maryeimy V L Laura L | | 0，，08： | 1 |
| 7 | Hysterosalpingography:A Reemerging Study显示文摘 | William L Simpson Laura G B | 2006 | Education Exhibit2006，26，2： | 1 |
| 8 | Con stitutive nuclear factor- kappa B activity is required for central neuron survival显示文摘 | ASHA L B LAURA L T CHRISTINE Z | 2002 | J Neurosci2002，22，： | 1 |
| 9 | Hyperspectral microwave atmospheric sounding显示文摘 | WILLIAM B J LAURA B J VINCENT L R | | 0，，01： | 1 |
| 10 | A study of the retrograda- tion process in five argentine rice starches显示文摘 | LAURA B I de MISHIMA B L MARIA C A | 2010 | LWT-Food Science and Technology2010，43，4： | 1 |
| 11 | Biosensors and Bioelectronics 显示文摘 | Laura G Rosana B L Marta E D | 2008 | 23(7): 1101-11082008，23，7： | 1 |
| 12 | Measuring core- stability显示文摘 | Wendell P L Ted A B Laura H G | 2005 | J Strength Condres2005，19，3： | 1 |
| 13 | Logistics education:A look at the current state of the art and science显示文摘 | HEATHER L LAURA B | 2013 | Supply Chain Management:An International Journal2013，18，： | 1 |
| 14 | Mitomycin C in Corneal Refractive Surgery 显示文摘 | Miguel A T Laura B L Jorge L A | 2009 | Survey of Oph- thalmology2009，54，4： | 1 |
| 15 | Nanosilver Particle Effects on Drug Metabolism In Vitro 显示文摘 | JOHN G L LAURA B H MARK A M | 2010 | Drug Metab Dispos2010，38，12： | 1 |
| 16 | Journal o{ Inorganic Biochemistry 显示文摘 | Wolfhardt F Loria M Alessandra C Chiara B Keith F T Wolf gang L Laura El C | 2008 | 102 13292008，102，： | 1 |
| 17 | Methanogens : a window into ancient sulfur metabolism 显示文摘 | Liu Y C Laura L B William B | 2012 | Trends in Microbiology May2012，21，5： | 1 |
| 18 | Radial basis functions for the multivariate interpolation of large scattered data sets 显示文摘 | Damiana L Laura B M | 2002 | Journal of Computational and Applied Mathematics2002，140，： | 1 |
| 19 | High-mobility Ultrathin Semiconducting Films Prepared by Spin Coating显示文摘 | David B M Laura L K Conal E M | 2004 | Letters to Nature2004，428，： | 1 |
| 20 | Wide-gene expression analysis of lipid-relevant genes in nutri- tionally challenged gilthead sea bream (Sparus aurata)显示文摘 | Laura B P Gabriel B L Jaume P S | 2014 | Gene2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员