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| 1 | Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment显示文摘AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue treatment.METHODS: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-HBe and normalization of alanine aminotransferase for at least 6 months.RESULTS: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were studied.Lamivudine was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug cessation.Genotype B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16(18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21%, P=0.25) and lamivudine-treated (14 % vs 10 %,P=1.00) groups.CONCLUSION: HBeAg seroconversion after treatment by lamivudine was not influenced by the HBV genotype. | Henry Lik-Yuen Chan May-Ling Wong Alex Yui Hui Angel Mei-Ling Chim Ada Mei-Ling Tse Lawrence Cheung-Tsui Hung Francis Ka-Leung Chan Joseph Jao-Yiu Sung | 2003 | World Journal of Gastroenterology2003，9，12： | 21 |
| 2 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors显示文摘 | Ben Lawrence Bjorn I. Gustafsson Anthony Chan Bernhard Svejda Mark Kidd Irvin M. Modlin | 2011 | Endocrinology and Metabolism Clinics of North America2011，，1： | 6 |
| 4 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 5 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 6 | Structure of Apolipoprotein B-100 of Human Low Density Lipoproteins显示文摘 | Chao-yuh Yang Zi-Wei Gu Shi-ai Weng Tae W. Kim San-Hwan Chen Henry J. Pownall Paul M. Sharp Shyan-Woei Liu Wen-Hsiung Li Antonio M. Gotto Lawrence Chan | 1989 | Arteriosclerosis, Thrombosis, and Vascular Biology1989，，1： | 2 |
| 7 | Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke显示文摘 | Colin A. Graham Rebecca W.Y. Chan Dexter Y.S. Chan Cangel P.Y. Chan Lawrence K.S. Wong Timothy H. Rainer | 2011 | Clinical Biochemistry . 2011 (4-5)2011，，： | 2 |
| 8 | T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity显示文摘 | Huaizhu Wu Sudip Ghosh Xiaoyuan Dai Perrard Lili Feng Gabriela E. Garcia Jerry L. Perrard John F. Sweeney Leif E. Peterson Lawrence Chan C Wayne Smith Christie M. Ballantyne | 2007 | Circulation2007，，8： | 1 |
| 9 | Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons显示文摘 | Xuemei Shi Fuguo Zhou Xiaojie Li Benny Chang Depei Li Yi Wang Qingchun Tong Yong Xu Makoto Fukuda Jean J. Zhao Defa Li Douglas G. Burrin Lawrence Chan Xinfu Guan | 2013 | Cell Metabolism2013，，1： | 1 |
| 10 | Sfold web server for statistical folding and rational design of nucleic acids 显示文摘 | Ding Y Chan C Y Lawrence C E | 2004 | Nucleic Acids Research2004，32，1： | 1 |
| 11 | Clustering of RNA secondary structures with application to messenger RNAs显示文摘 | DING Y CHAN C Y LAWRENCE C E | 2006 | J Mol Biol2006，359，3： | 1 |
| 12 | Viruses causing lysis of the toxic bloom-forming alga Heterosigma akashiwo (Raphidophyceae) are widespread in coastal sediments of British Columbia, Canada 显示文摘 | Lawrence J E Chan A M Suttle C A | 2002 | Limnol Oceanogr2002，47，： | 1 |
| 13 | Clustering of RNA secondary structures with application to messenger RNAs显示文摘 | Ding Y Chan C Y Lawrence C E | 2006 | Journal of Mo- lecular Biology2006，359，3： | 1 |
| 14 | Erythrocytic Sedimentation Rate as a Measure of Clinical Activity in Inflammatory Bowel Disease显示文摘 | David B. Sachar Harry Smith Simon Chan Lawrence B. Cohen Simon Lichtiger Julio Messer | 1986 | Journal of Clinical Gastroenterology1986，，6： | 1 |
| 15 | Reirradiation of Locally Recurrent Nasopharynx Cancer With External Beam Radiotherapy With or Without Brachytherapy显示文摘 | Lawrence Koutcher Nancy Lee Michael Zelefsky Kelvin Chan Gilad Cohen David Pfister Dennis Kraus Suzanne Wolden | 2010 | International Journal of Radiation Oncology Biology Physics2010，，1： | 1 |
| 16 | The epidemiology of gastroenteropancreatic neuroendocrine tumors 显示文摘 | Lawrence B Gustafsson BI Chan A | 2011 | Endocrinol Metab Clin North Am2011，40，1： | 1 |
| 17 | The epidemiology of gastroenteropancreatic neuroendocrine tumors显示文摘 | Lawrence B Gustafsson BI Chan A | 2011 | Endocrinol Metab Clin North Am2011，40，1： | 1 |
| 18 | The epidemiology of gastroenteropancreatic neuroendocrine tumors 显示文摘 | Lawrence B Gustafsson BI Chan A | 2011 | Endocrinol Metab Clin North Am2011，40，1： | 1 |
| 19 | The epidemiology of gastroenteropancreatic neuroendocrine tumo~ 显示文摘 | Lawrence B Gustafsson BI Chan A | 2011 | Endocrinol Metab Clin North Am2011，40，： | 1 |
| 20 | Adiponectin regulates albuminuria and podocyte function in mice显示文摘 | Sharma Kumar RamachandraRao Satish Qiu Gang Usui Hitomi Kataoka Zhu Yanqing Dunn Stephen R Ouedraogo Raogo Hough Kelly McCue Peter Chan Lawrence Falkner Bonita Goldstein Barry J | 2008 | Journal of Clinical Investigation2008，，5： | 1 |
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