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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘 | Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 20 |
| 3 | 文献快报(9):近视发病年龄与成年后高度近视的风险相关显示文摘中山大学中山眼科中心眼科国家重点实验室的何明光教授团队最近在《JAMA Ophthalmol》上发表新的研究结果,提示了近视发病年龄与成年后高度近视的风险的相关性。这项研究是一项基于人群的双胞胎前瞻性队列研究,从2006年7月11日在中国广州开始进行。该研究分析了从基线到2018年8月31日的数据。 | HU Y DING X GUO X 麦锦城(编译) | 2020 | 中国学校卫生2020，41，12： | 14 |
| 4 | The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘 | Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 5 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 6 | Eudesmanes and Eudesmanoic Glucosides from Laggera pterodonta显示文摘EudesmanesandEudesmanoicGlucosidesfromLaggerapterodonta￥YuZHAO;JianMinYue;JingKaiDING;ZhongWenLinandHanDongSUN(Laboratoryofph... | Zhao, Y Yue, JM Ding, JK Lin, ZW Sun, HD | 1996 | Chinese Chemical Letters1996，7，12： | 7 |
| 7 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 8 | Recognition Interactions of Metal-complexing Imprinted Polymer显示文摘Molecularly imprinted polymer, exhibiting considerable enantioselectivity for L-mandelic acid, was prepared using metal coordination-chelation interaction. By evaluating the recognition characteristics in the chromatographic mode, the recognition interactions were proposed: specific and nonspecific metal coordination-chelation interaction and hydrophobic interaction were responsible for substrate binding on metal-complexing imprinted polymer; while the selective recognition only came from specific metal coordination-chelation interaction and specific hydrophobic interaction. | Liu, Y Ding, GS De Wang, J | 2005 | Chinese Chemical Letters2005，16，6： | 5 |
| 9 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 10 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 11 | Characteristics of alpha-synucleinopathy in centenarians显示文摘 | Ding ZT Wang Y Jiang YP Hashizume Y Yoshida M Mimuro M Inagaki T Iwase T | 2006 | 中国生物学文摘2006，20，8： | 4 |
| 12 | Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘 | Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 4 |
| 13 | Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice显示文摘Background:Acetaminophen(APAP)overdose can cause liver injury and liver failure,which is one of the most common causes of drug-induced liver injury in the United States.Pharmacological activation of autophagy by inhibiting mechanistic target of rapamycin(mTOR)protects against APAP-induced liver injury likely via autophagic removal of APAP-adducts and damaged mitochondria.In the present study,we aimed to investigate the role of genetic ablation of mTOR pathways in mouse liver in APAP-induced liver injury and liver repair/regeneration.Methods:Albumin-Cre(Alb-Cre)mice,mTOR^(f/f) and Raptor^(f/f) mice(C57BL/6J background)were crossbred to produce liver-specific mTOR knockout(L-mTOR KO,Alb Cret/-,mTOR^(f/f))and liver-specific Raptor KO(L-Raptor,Alb Cret/-,Raptor^(f/f))mice.Alb-Cre littermates were used as wild-type(WT)mice.These mice were treated with APAP for various time points for up to 48 h.Liver injury,cell proliferation,autophagy and mTOR activation were determined.Results:We found that genetic deletion of neither Raptor,an important adaptor protein in mTOR complex 1,nor mTOR,in the mouse liver significantly protected against APAP-induced liver injury despite increased hepatic autophagic flux.Genetic deletion of Raptor or mTOR in mouse livers did not affect APAP metabolism and APAP-induced c-Jun N-terminal kinase(JNK)activation,but slightly improved mouse survival likely due to increased hepatocyte proliferation.Conclusions:Our results indicate that genetic ablation of mTOR in mouse livers does not protect against APAP-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose. | Hua Sun Hong-Min Ni Jennifer M.McCracken Jephte Y Akakpo Sam Fulte Tara McKeen Hartmut Jaeschke Hua Wang Wen-Xing Ding | 2021 | Liver Research2021，5，2： | 3 |
| 14 | Molecular dynamics simulation and continuum modelling of granular surface flow in rotating drums显示文摘Numerical simulations of granular flows in rotating drums operated at medium to high rates (Fr=0.1― 0.2) have been carried out by using a Molecular Dynamics (MD) algorithm that incorporates inelastic particle interactions, sliding friction and rolling friction. The results indicate that the behavior of granular flow in rotating drums can be classified into two distinct zones: a shear active layer at the bed surface and a quasi-static plug flow region adjacent to the wall. The residence time of a tracer particle in the active layer is approximately a third or a half of that in the plug flow region. The thickness of the active layer at mid-chord is about 0.57―0.61 times that of the plug flow region. It is found that all cases simulated in this work are in the rolling-cascading intermediate regime instead of the pure rolling re-gime. The simulated tangential velocity at the mid-chord is also compared with experimental results reported in the literature and good agreement has been obtained. Based on the MD simulations and experimental results, a continuum approach has also been developed. It is shown that the behavior of granular solids in the plug flow region experiences plastic deformation along the radial direction from the wall with the velocity profiles well described by an exponential function, whereas the active layer velocity follows a simple expression for the Couette shear flow. Discussion has also been made on the granular temperature and concentration profiles. | LI ShuiQing YAO Qiang CHEN Bing ZHANG Xuan DING Y L | 2007 | Chinese Science Bulletin2007，52，5： | 3 |
| 15 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 16 | Research and experiments of the dynamical model system for short-term climate prediction显示文摘 | Ding Y H Liu Y .M Song J | | 气候与环境研究0，，： | 2 |
| 17 | Numerical simulations of morphological changes in barrier islands induced by storm surges and waves using a supercritical flow model显示文摘在这份报纸,一个先进明确的有限体积流动模型在二尺寸为模仿 supercritical 被介绍在一个潮汐 / 沿海的入口和障碍岛的沿海的流动和词法变化由于暴风雨巨浪和波浪。这个流动模型被结合存在波浪行动模型和沉积运输模型。结果综合沿海的过程模型能够模仿象快速的沿海的水流导致的波浪和波浪那样的极端条件导致的流动。这个发达 supercritical 流动模型与 Coriolis 力量,不平的深测术,风压力,和波浪放射压力的效果基于非线性的浅水方程的保守形式的答案。前面的 Euler 计划被用于不稳定的条款;并且对流条款是用与不一致的直线格子上的 HLL Riemann 解答者一起的 Godunov 类型 shockcapturing 计划的 discretized。发达模型的精确性被解决一个试验性的水坝裂缝测试用例调查。由于严重暴风雨攻击的突破的障碍岛,溢出和冲洗被模仿,联系到事件的预言的词法变化被分析在所有物理力量是在场的海岸调查模型的适用性。 | Soumendra Nath KUIRY Yan DING Sam S Y WANG | 2014 | Frontiers of Structural and Civil Engineering2014，8，1： | 2 |
| 18 | Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin显示文摘 | Y Ding J Li X Luan Y.H Ding Q Lai J.A Rafols J.W Phillis J.C Clark F.G Diaz | 2004 | Neuroscience2004，，3： | 2 |
| 19 | 基于影像表现预测骨关节炎进展显示文摘目前常用X线检查评估骨关节炎(OA)进展,MRI可了解OA初期至晚期关节功能丧失阶段进展规律。最新研究表明,MRI检测到的关节结构异常变化,如软骨缺损和骨髓水肿增加,软骨体积和厚度减少,软骨成分改变等可用于评估OA进展。肥胖、肌肉萎缩、关节内外翻、代谢性疾病、炎症和关节疼痛等临床危险因素及软骨损伤、骨髓水肿、半月板病变、滑膜炎等影像学特征等关节结构因素均与OA进展有关。改善这类危险因素,可减缓疾病进展;利用MRI监测疾病进展,发现新的危险因素,并对危险因素进行干预,有助于阻断OA进展。对处于高危险因素人群进行临床试验研究,可减少试验样本量和随访时间,增强临床试验研究效率。该文主要介绍OA进展的最新流行病学和临床研究证据,以及与OA进展相关的危险因素。 | 徐勤光 韦宋谱 王学宗 丁道芳 庞坚 郑昱新 曹月龙 詹红生 Ding C Zhang Y Hunter D | 2013 | 国际骨科学杂志2013，34，2： | 2 |
| 20 | 儿童结节性硬化症研究揭示其基因型和表型关系显示文摘背景结节性硬化综合症(Tuberous sclerosi complex,TSC)(OMIM 54#191100,#613254)是最常见的神经皮肤综合征,为常染色体显性遗传病目前已知的致病基因为TSC1(OMIM:605 284)和TSC2(OMIM:101 092)。人群患病率为1/20 000发病率为1/(6 000~10 000)活产婴儿。TSC1/TSC2基因的突变导致mTOR通路的异常,从而出现各系统症状。 | 丁一峰 王艺 Ding Y Wang J Zhou S | 2020 | 癫痫杂志2020，6，6： | 2 |
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