|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | MLVA-16 对新疆分离布鲁氏菌80/23株的鉴定与分析显示文摘为了对新疆布鲁氏菌分离株80/23株进行分型鉴定,本实验采用MLVA-16检测方法和常规生物学鉴定方法对布鲁氏80/23株进行研究,将测定结果与http://gffzzc70700eb713d4f53hnoqvuukvxob06u60.ffgz.tsg.suse.edu.cn/MLVA net提供的530株布鲁氏菌数据库比较分析,应用UPGMA进行遗传进化树分析,并构建系统进化树。结果显示,常规分型方法鉴定为羊种3型,MLVA方法鉴定该菌株与德国分离株Bruce0261菌株的亲缘关系最近,属为东地中海3型,羊种1型,两种分型方法种属结果一致。结论:MLVA-16与常规生物学鉴定方法相比,具有更高的精确性,对布鲁氏菌生物型和株间差异有很高的鉴别力。并能为布病疫情流行株的溯源进化关系提供依据。 | 任晓莉 王慧 陈创夫 王远志 张亚丽 Philippe Le Flèche | 2013 | 石河子大学学报(自然科学版)2013，31，3： | 6 |
| 3 | 软木塞基碳量子点的水热合成及其生物相融荧光成像应用显示文摘以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。用硫酸奎宁作为参考,碳量子点的量子效率为1.54%。将获得的碳量子点应用在骨髓间充质干细胞的细胞生物成像上,发现用碳量子点处理后,骨髓间充质干细胞分别在320~380 nm、450~490 nm和450~490 nm范围显示绿色、黄色和红色荧光,表明了碳量子点在荧光成像领域具有潜在的应用价值。 | Quang Ngo Khoa Hieu Nguyen Ngoc Bao Vo Van Quoc Phuoc Vo Thi Ngoc Le Xuan Diem Doc Luong Quang Tri Nguyen Minh Son Le Vu Truong Son Le Van Thanh Ha Che Thi Cam | 2022 | 新型炭材料2022，37，3： | 3 |
| 4 | Study of the location of testing area in residual stress measurement by Moiré interferometry combined with hole-drilling method显示文摘This paper investigates the effect of the location of testing area in residual stress measurement by Moiréinterferometry combined with hole-drilling method.The selection of the location of the testing area is analyzed from theory and experiment.In the theoretical study,the factors which affect the surface released radial strainεr were analyzed on the basis of the formulae of the hole-drilling method,and the relations between those factors andεr were established.By combining Moiréinterferometry with the hole-drilling method,the residual stress of interference-fit specimen was measured to verify the theoretical analysis.According to the analysis results,the testing area for minimizing the error of strain measurement is determined.Moreover,if the orientation of the maximum principal stress is known,the value of strain will be measured with higher precision by the Moiréinterferometry method. | QIN Le XIE HuiMin ZHU RongHua WU Dan CHE ZhiGang ZOU ShiKun | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 2 |
| 5 | Preparation of Al-based amorphous coatings and their properties显示文摘Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings were prepared using cold gas kinetic spray technology.The results show that Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings are achieved with the porosity about 3.2%,thickness about 893 μm,the amount of amorphous phase about 82.5%,the hardness about 300 HV0.2.The corrosion potential and anti-corrosion life of 7075 T6 alloy aluminum are about-0.78 V and 72 h,respectively.The electrochemical analysis and neutral salt spray are about-0.69 V corrosion potential and 274 h anti-corrosion life for amorphous Al-based coatings,respectively.Therefore,the life of the Albased amorphous coatings is about 3.8 times that of 7075 T6 aluminum alloy.Besides,the failure mechanism was analyzed using TEM in this investigation.In a word,Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) coatings keep dense structure,high amorphous content,favorable amorphous phase stabilizing ability and longer anticorrosion life.That is,Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) coatings have better comprehensive properties.Therefore,these findings indicate that the present Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings prepared using cold gas kinetic spray technique can protect aluminum alloy very well and they can be considered to be used in aviation field. | Lei Jin Le Zhang Kaige Liu Zhigang Che Kai Li Ming Zhang Bo Zhang | 2021 | Journal of Rare Earths2021，39，3： | 1 |
| 6 | Fermi surface gapping in the hidden order state of PrFe_(4)P_(12);by point-contact spectroscopy显示文摘We have applied point-contact spectroscopy(PCS) to investigate the nonmagnetic hidden order(HO) state of the skutterudite compound PrFe_(4)P_(12) with its transition temperature THO~6.5 K. Its point-contact conductance curves exhibit a reproducible gap structure in the HO state below THOand its temperature dependent gap magnitude follows a BCS-like mean-field behavior.A Fano-like conductance shape is observed to emerge below the coherence temperature of PrFe_(4)P_(12). In a magnetic field, the gap feature is gradually suppressed and evolves into a pronounced Fano peak, signaling the heavy fermion state and vividly demonstrating the competition between HO and the formation of heavy fermion states. Our results strongly suggest the itinerant characteristic of f electrons in PrFe_(4)P_(12), which constrains theoretical models to explain the HO mechanism. | Tian Le LiQiang Che Qi Huang Kevin Huang ZhaoFeng Ding Lei Shu Xin Lu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，3： | 1 |
| 7 | Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay显示文摘 | Le Flèche P Jacques I GrayonM | | 0，，： | 1 |
| 8 | High resolution,on-line identification of strains from the Mycobacterium tuberculosis complex based on tandem repeat typing显示文摘 | Le Flèche P Fabre M Denoeud F Koeck JL Vergnaud G | 2002 | BMC Microbiol2002，27，2： | 1 |
| 9 | MLVA-16 typing of 295 marine mammal Brucella isolates from different animal and geographic origins identifies 7 major groups within Brucella ceti and Brucella pinnipedialis显示文摘 | Maquart M Le Flèche P Foster G | | 0，，： | 1 |
| 10 | Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay显示文摘 | Le Flèche P Jacques I Grayon M | | 0，，： | 1 |
| 11 | A tandem repeats database for bacterial genomes:application to the genotyping of Yersinia pestis and Bacillus anthracis显示文摘 | Le Flèche P Hauck Y Onteniente L | 2001 | BMC Microbiol2001，1，1： | 1 |
| 12 | Genotyping of French Bacillus anthracis strains based on 31-loci multiloeus VNTR analysis : epidemiology, marker evaluation, and update of the in- teruet genotype database显示文摘 | Thierry S Tourterel C Le Fli~che P | 2014 | PLoS One2014，9，95： | 1 |
| 13 | MLVA-16 typing of 295 marine mammal Brucella isolates from different animal and geographic origins identifies 7 major groups within BruceUa ceti and Brucella pinnipedialis显示文摘 | Maquart M Le Fl~che P Foster G | 2009 | BMC Microbiol2009，9，： | 1 |
| 14 | Evaluation andselection of tandem repeat loci for a Brucella MLVA typ-ingassay显示文摘 | Le Flèche P Jacques I Grayon M | 2006 | BMC Microbiol2006，6，： | 1 |
| 15 | A tandem repeats database for bacterial genomes:application to the genotyping of Yersinia pestis and Bacillus anthracis显示文摘 | Le Flèche P Hauck Y Onteniente L | | 0，，： | 1 |
| 16 | High resolution,on-line indentification of strains from the Mycobacterium tuberculosis complex based on tandem repeat typing显示文摘 | Le Flèche P Fabre M Denoeud F | 2002 | BMC Microbiol2002，2，： | 1 |
| 17 | 显示文摘 | Che M Tatibouet J M | 1993 | J Catal1993，142，： | 1 |
| 18 | Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay显示文摘 | Le Flèche P Jacques I Grayon M | 2006 | BMC Microbiol2006，6，： | 1 |
| 19 | Genome size evolution of the extant lycophytes and ferns显示文摘Ferns and lycophytes have remarkably large genomes.However,little is known about how their genome size evolved in fern lineages.To explore the origins and evolution of chromosome numbers and genome size in ferns,we used flow cytometry to measure the genomes of 240 species(255 samples)of extant ferns and lycophytes comprising 27 families and 72 genera,of which 228 species(242 samples)represent new reports.We analyzed correlations among genome size,spore size,chromosomal features,phylogeny,and habitat type preference within a phylogenetic framework.We also applied ANOVA and multinomial logistic regression analysis to preference of habitat type and genome size.Using the phylogeny,we conducted ancestral character reconstruction for habitat types and tested whether genome size changes simultaneously with shifts in habitat preference.We found that 2 C values had weak phylogenetic signal,whereas the base number of chromosomes(x)had a strong phylogenetic signal.Furthermore,our analyses revealed a positive correlation between genome size and chromosome traits,indicating that the base number of chromosomes(x),chromosome size,and polyploidization may be primary contributors to genome expansion in ferns and lycophytes.Genome sizes in different habitat types varied significantly and were significantly correlated with habitat types;specifically,multinomial logistic regression indicated that species with larger 2 C values were more likely to be epiphytes.Terrestrial habitat is inferred to be ancestral for both extant ferns and lycophytes,whereas transitions to other habitat types occurred as the major clades emerged.Shifts in habitat types appear be followed by periods of genomic stability.Based on these results,we inferred that habitat type changes and multiple whole-genome duplications have contributed to the formation of large genomes of ferns and their allies during their evolutionary history. | Fa-Guo Wang Ai-Hua Wang Cheng-Ke Bai Dong-Mei Jin Li-Yun Nie AJ Harris Le Che Juan-JuanWang Shi-Yu Li Lei Xu Hui Shen Yu-Feng Gu Hui Shang Lei Duan Xian-Chun Zhang Hong-Feng Chen Yue-Hong Yan | 2022 | Plant Diversity2022，44，2： | 0 |
| 20 | Phenomic Imaging显示文摘Human phenomics is defned as the comprehensive collection of observable phenotypes and characteristics infuenced by a complex interplay among factors at multiple scales.These factors include genes,epigenetics at the microscopic level,organs,microbiome at the mesoscopic level,and diet and environmental exposures at the macroscopic level.“Phenomic imaging”utilizes various imaging techniques to visualize and measure anatomical structures,biological functions,metabolic processes,and biochemical activities across diferent scales,both in vivo and ex vivo.Unlike conventional medical imaging focused on disease diagnosis,phenomic imaging captures both normal and abnormal traits,facilitating detailed correlations between macro-and micro-phenotypes.This approach plays a crucial role in deciphering phenomes.This review provides an overview of diferent phenomic imaging modalities and their applications in human phenomics.Additionally,it explores the associations between phenomic imaging and other omics disciplines,including genomics,transcriptomics,proteomics,immunomics,and metabolomics.By integrating phenomic imaging with other omics data,such as genomics and metabolomics,a comprehensive understanding of biological systems can be achieved.This integration paves the way for the development of new therapeutic approaches and diagnostic tools. | Lizhen Lan Kai Feng Yudan Wu Wenbo Zhang Ling Wei Huiting Che Le Xue Yidan Gao Ji Tao Shufang Qian Wenzhao Cao Jun Zhang Chengyan Wang Mei Tian | 2023 | Phenomics2023，3，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员