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| 1 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 2 | 经腹股沟及腹股沟下显微精索静脉结扎术:精索静脉曲张的最佳手术治疗方式的荟萃分析显示文摘以往精索静脉曲张各种治疗方法疗效的荟萃分析存在不一致的结果。因此,我们进行了多种干预措施的荟萃分析,评估10种精索静脉曲张栓塞/硬化治疗方法的有效性和安全性,包括腹腔镜、腹膜后开放、经腹股沟开放和腹股沟下开放静脉结扎,腹股沟下显微和经腹股沟显微精索静脉结扎术,经皮静脉栓塞,TauberJl~行硬化,硬化逆行和期待治疗(无处理)。我们系统回顾了从1966年至2013年8月的35个随机对照试验和观察性研究。经腹股沟、腹股沟下显微手术、腹股沟开放、腹腔镜精索静脉结扎与期待治疗相比显著提高夫妻怀孕率(优势比[OR]分别为:3.48,2.68,2.92和2.9)。与腹膜后开放手术相比,经腹股沟显微手术显著提高患者的精子密度(平均差【MD]:10.60,95%CI:1.92—19.60)并改善精子运动(MD:9.09,95%CI:4.88—13.30)。经腹股沟下和腹股沟显微手术在复发率方面的表现优于开放腹膜后手术(OR分别为0.05,O.06)。Tauber顺行硬化和腹股沟下显微精索静脉结扎术的鞘膜积液形成的风险最低。与腹膜后开放精索静脉曲张术相比,腹股沟显微精索静脉结扎术的总的并发症率最低(OR=O.07,95%CI:0.02。0.19)。其次是腹股沟下显微(OR:O.09,95%CI:0.02.0.19)。经腹股沟显微和腹股沟下显微精索静脉曲张结扎术对提高患者怀孕率有良好的效果,能显著增加精子数量,并有着较低的并发症率。本文研究结果仍需要经过良好设计的随机对照临床研究进一步证实。 | Jun Wang Shu-Jie Xia Zhi-Hong Liu Le Tao Ji-Fu Ge Chen-Min Xu Jian-Xin Qiu | 2015 | Asian Journal of Andrology2015，17，1： | 16 |
| 3 | Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice显示文摘 | Li-qing WENG Wen-bin ZHANG Yong YE Pei-pei YIN Jie YUAN Xing-xu WANG Le KANG Sha-sha JIANG Jie-yun YOU Jian WU Hui GONG Jun-bo GE Yun-zeng ZOU | 2014 | Acta Pharmacologica Sinica2014，35，8： | 12 |
| 4 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 5 | Compromised cerebrovascular modulation in chronic anxiety:evidence from cerebral blood flow velocity measured by transcranial Doppler sonography显示文摘客观服的自动调整(CA ) 是尽管有变化,经常的服的血流动被在服的灌注压力维持的机制。CA 能被与 transcranial Doppler sonography (TCD ) 的服的血流动速度(CBFV ) 的动态监视评估。现在的学习试图长期的焦虑地探索 CA。有哈密尔顿焦虑的方法题目放大分数 14 被注册,响应 orthostatic 挑战的 CBFV 的动态变化用 TCD 被调查。在两个的结果焦急并且健康题目,吝啬的 CBFV 在正直的位置是显著地更低的比什么时候仰卧。然而, CBFV 变化从对仰卧笔直地不同在之间焦急并且健康的组。焦急题目与突然的站在 CBFV 显示出更显著的减少。我们的结果显示那脑血管的调整的结论长期的焦虑地被损害;焦急题目在在姿势的变化以后维持服的灌注有某不足。给焦虑和损害 CA 与心血管的疾病被联系,用 TCD 的损害脑血管的调整的早探查可能在焦急人口建议 interventional 治疗,并且改进心血管的疾病的主要预防的事实。 | Hong-Liang Zhang Zhen-Ni Guo Ge Yang Le Yang Ke Han Jiang Wu Yingqi Xing Yi Yang | 2012 | Neuroscience Bulletin2012，28，6： | 11 |
| 6 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 7 | Nonlinear fault detection based on locally linear embedding显示文摘In this paper,a new nonlinear fault detection technique based on locally linear embedding(LLE)is developed.LLE can effciently compute the low-dimensional embedding of the data with the local neighborhood structure information preserved.In this method,a data-dependent kernel matrix which can reflect the nonlinear data structure is defned.Based on the kernel matrix,the Nystr o¨m formula makes the mapping extended to the testing data possible.With the kernel view of the LLE,two monitoring statistics are constructed.Together with the out of sample extensions,LLE is used for nonlinear fault detection.Simulation cases were studied to demonstrate the performance of the proposed method. | Aimin MIAO Zhihuan SONG Zhiqiang GE Le ZHOU Qiaojun WEN | 2013 | 控制理论与应用(英文版)2013，11，4： | 8 |
| 8 | Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma显示文摘AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and TTP.RESULTS: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to OS.CONCLUSION: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter. | Jing-Huan Li Xiao-Ying Xie Lan Zhang Fan Le Ning-Ling Ge Li-Xin Li Yu-Hong Gan Yi Chen Ju-Bo Zhang Tong-Chun Xue Rong-Xin Chen Jing-Lin Xia Bo-Heng Zhang Sheng-Long Ye Yan-Hong Wang Zheng-Gang Ren | 2015 | World Journal of Gastroenterology2015，21，13： | 6 |
| 9 | Correlation of Deactivation of Ni-Mo-W/Al2O3 during Ultra-Low-Sulfur Diesel Production with Surface Carbon Species显示文摘The deactivation of a Ni-Mo-W/Al_2O_3 catalyst during ultra-low-sulfur diesel production was investigated in a pilot plant. The reasons of catalyst deactivation were analyzed by the methods of elemental analysis, BET and TG-MS. The results showed that the catalyst deactivation rate was notable at the beginning of run, and then gradually reached a steady state after 448 h. In the initial period the catalyst deactivation may mainly be caused by the formation of the carbon deposits. The carbon deposits blocked the catalyst pores and the accessibility of active center decreased. The TG-MS analysis identified three types of carbon species deposited on the catalysts, viz.: the low temperature carbon deposit with high H/C atomic ratio, the medium temperature carbon deposit, and the high temperature carbon with low H/C atomic ratio. The amount of high temperature carbon deposits on the catalyst determined the overall activity and, therefore the high temperature carbon was a major contributor to the deactivation of Ni-Mo-W catalyst. | Ge Panzhu Zhang Le Ding Shi Li Dadong Nie Hong | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 5 |
| 10 | Force chains based mesoscale simulation on the dynamic response of Al-PTFE granular composites显示文摘Force chains based mesoscale simulation is conducted to investigate the response behavior of aluminumpolytetrafluoroethylene(Al-PTFE)granular composites under a low-velocity impact.A two-dimensional model followed the randomly normal distribution of real Al particles size is developed.The dynamic compressive process of Al-PTFE composites with varied Al mass fraction is simulated and validated against the experiments.The results indicate that,force chains behavior governed by the number and the size of agglomerated Al particles,significantly affects the impact response of the material.The failure mode of the material evolves from shear failure of matrix to debonding failure of particles with increasing density.A high crack area of the material is critical mechanism to arouse the initiation reaction.The damage maintained by force chains during large plastic strain builds up more local stresses concentration to enhance a possible reaction performance.In addition,simulation is performed with identical mass fraction but various Al size distribution to explore the effects of size centralization and dispersion on the mechanical properties of materials.It is found that smaller sized Al particle of composites are more preferred than its bulky material in ultimate strength.Increasing dispersed degree is facilitated to create stable force chains in samples with comparable particle number.The simulation studies provide further insights into the plastic deformation,failure mechanism,and possible energy release capacity for Al-PTFE composites,which is helpful for further design and application of reactive materials. | Le Tang Chao Ge Huan-guo Guo Qing-bo Yu Hai-fu Wang | 2021 | Defence Technology(防务技术)2021，17，1： | 5 |
| 11 | Effect of wave shaper on reactive materials jet formation and its penetration performance显示文摘Wave shaper effect on formation behavior and penetration performance of reactive liner shaped charge(RLSC)are investigated by experiments and simulations.The reactive materials liner with a density of2.3 g/cm^3 is fabricated by cold pressing at a pressure of 300 MPa and sintering at a temperature of 380℃.Experiments of the RLSC with and without wave shaper against steel plates are carried out at standoffs of0.5,1.0,and 1.5 CD(charge diameter),respectively.The experimental results show that the penetration depths and structural damage effects of steel plates decrease with increasing the standoff,while the penetration depths and the damage effects of RLSC without wave shaper are much greater than that with wave shaper at the same standoff.To understand the unusual experimental results,numerical simulations based on AUTODYN-2 D code are conducted to discuss the wave shaper effect,including the propagation behavior of detonation wave,the velocity and temperature distribution of reactive jet,and penetration depth of reactive jet.The simulations indicate that,compared with RLSC without wave shaper,there is a higher temperature produced inside reactive jet with wave shaper.This unusual temperature rise effects are likely to be an important mechanism to cause the initiation delay time of reactive jet to decline,which results in significantly decreasing its penetration performance. | Huan-guo Guo Yuan-feng Zheng Le Tang Qing-bo Yu Chao Ge Hai-fu Wang | 2019 | Defence Technology(防务技术)2019，15，4： | 4 |
| 12 | Leveraging proficiency and preference for online Karaoke recommendation显示文摘Recently,many online Karaoke(KTV)platforms have been released,where music lovers sing songs on these platforms.In the meantime,the system automatically evaluates user proficiency according to their singing behavior.Recommending approximate songs to users can initialize singers5 participation and improve users,loyalty to these platforms.However,this is not an easy task due to the unique characteristics of these platforms.First,since users may be not achieving high scores evaluated by the system on their favorite songs,how to balance user preferences with user proficiency on singing for song recommendation is still open.Second,the sparsity of the user-song interaction behavior may greatly impact the recommendation task.To solve the above two challenges,in this paper,we propose an informationfused song recommendation model by considering the unique characteristics of the singing data.Specifically,we first devise a pseudo-rating matrix by combing users’singing behavior and the system evaluations,thus users'preferences and proficiency are leveraged.Then we mitigate the data sparsity problem by fusing users*and songs'rich information in the matrix factorization process of the pseudo-rating matrix.Finally,extensive experimental results on a real-world dataset show the effectiveness of our proposed model. | Ming HE Hao GUO Guangyi LV Le WU Yong GE Enhong CHEN Haiping MA | 2020 | Frontiers of Computer Science2020，14，2： | 3 |
| 13 | Various atomic structures of monolayer silicene fabricated on Ag(111)显示文摘 | Zhi-Long Liu Mei-Xiao Wang Jin-Peng Xu Jian-Feng Ge Guy Le Lay Patrick Vogt Dong Qian Chun-Lei Gao Canhua Liu Jin-Feng Jia | 2014 | New Journal of Physics2014，，： | 3 |
| 14 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 15 | Probability hypothesis density filter with adaptive parameter estimation for tracking multiple maneuvering targets显示文摘The probability hypothesis density(PHD) filter has been recognized as a promising technique for tracking an unknown number of targets. The performance of the PHD filter, however, is sensitive to the available knowledge on model parameters such as the measurement noise variance and those associated with the changes in the maneuvering target trajectories. If these parameters are unknown in advance, the tracking performance may degrade greatly. To address this aspect, this paper proposes to incorporate the adaptive parameter estimation(APE) method in the PHD filter so that the model parameters, which may be static and/or time-varying, can be estimated jointly with target states. The resulting APE-PHD algorithm is implemented using the particle filter(PF), which leads to the PF-APE-PHD filter. Simulations show that the newly proposed algorithm can correctly identify the unknown measurement noise variances, and it is capable of tracking multiple maneuvering targets with abrupt changing parameters in a more robust manner, compared to the multi-model approaches. | Yang Jinlong Yang Le Yuan Yunhao Ge Hongwei | 2016 | Chinese Journal of Aeronautics2016，29，6： | 2 |
| 16 | miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition显示文摘Human dental pulp stem cells(DPSCs)have emerged as an important source of stem cells in the tissue engineering,and hypoxia will change various innate characteristics of DPSCs and then affect dental tissue regeneration.Nevertheless,little is known about the complicated molecular mechanisms.In this study,we aimed to investigate the influence and mechanism of miR-140-3p on DPSCs under hypoxia condition.Hypoxia was induced in DPSCs by Cobalt chloride(CoCl_(2))treatment.The osteo/dentinogenic differentiation capacity of DPSCs was assessed by alkaline phosphatase(ALP)activity,Alizarin Red S staining and main osteo/dentinogenic markers.A luciferase reporter gene assay was performed to verify the downstream target gene of miR-140-3p.This research exhibited that miR-140-3p promoted osteo/dentinogenic differentiation of DPSCs under normoxia environment.Furthermore,miR-140-3p rescued the CoCl_(2)-induced decreased osteo/odontogenic differentiation potentials in DPSCs.Besides,we investigated that miR-140-3p directly targeted lysine methyltransferase 5B(KMT5B).Surprisingly,we found inhibition of KMT5B obviously enhanced osteo/dentinogenic differentiation of DPSCs both under normoxia and hypoxia conditions.In conclusion,our study revealed the role and mechanism of miR-140-3p for regulating osteo/dentinogenic differentiation of DPSCs under hypoxia,and discovered that miR-140-3p and KMT5B might be important targets for DPSC-mediated tooth or bone tissue regeneration. | Han Zheng Ning Wang Le Li Lihua Ge Haichao Jia Zhipeng Fan | 2021 | International Journal of Oral Science2021，13，4： | 2 |
| 17 | Composition and emission dynamics of migratory locust volatiles in response to changes in developmental stages and population density显示文摘化学通讯在蝗虫在密度依赖者阶段变化起一个重要作用。然而,迁移的蝗虫的不稳定的部件和排出物模式,草之小穗 migratoria,大部分是未知的。在这研究,我们从身体和排汇物识别了化学作文和蝗虫 volatiles 的排放动力学并且把他们与发展阶段,性和阶段变化联系了。迁移的蝗虫与荒芜的蝗虫(Schistocerca gregaria ) 分享很多个不稳定的部件,但是二蝗虫种的排放动力学是显著地不同的。在迁移的蝗虫的群居的美女的身体气味由 phenylacetonitrile (平底锅) 组成了, benzaldehyde, guaiacol,酚,脂肪族的酸和 2,3-butanediol,和平底锅是主导不稳定。从美女的烘便的小团的 Volatiles 首先由 guaiacol 和酚组成。主要部件分析(PCA ) 在在群居、独居的蝗虫之间的不稳定的侧面显示出重要差别。平底锅和 4-vinylanisole 集中比在独居的蝗虫在群居的个人是显著地更高的。群居的成熟男性比成熟女性和两性的不成熟的成年人在成人生活期间释放了平底锅和 4-vinylanisole 的显著地更高的数量。而且,平底锅和 4-vinylanisole 完全在 solitarization 过程期间在群居的美女被失去,但是被独居的美女在 gregarization 期间获得。benzaldehyde, guaiacol 和酚的数量仅仅单向性地减少了从对拥挤的处理独居。脂肪族的醛(到 C10 的 C7 ) 以前作为蝗虫 volatiles 被报导,是作为环境沾染物识别的现在。因此,我们的结果在发展阶段,性和阶段变化期间说明迁移的蝗虫的精确气味侧面。然而,平底锅和另外的芳香的混合物的功能和角色需要在阶段转变期间推进调查。 | Jianing Wei Wenbo Shao Xianhui Wang Jin Ge Xiangyong Chen Dan Yu Le Kang | 2017 | Insect Science2017，24，1： | 2 |
| 18 | In Vivo and In Vitro Pharmacological Studies of Methoxycarbonyl-Carboetomidate显示文摘 | Ervin Pejo Joseph F. Cotten Elizabeth W. Kelly Ri Le Ge Gregory D. Cuny Joydev K. Laha Jifeng Liu Xiang Jie Lin Douglas E. Raines | 2012 | Anesthesia & Analgesia2012，，： | 2 |
| 19 | Temporal branch retinal vein obstruction: a review显示文摘 | Magargal LE Sanborn GE Kimmel AS | 1986 | Ophthal Surg1986，17，4： | 1 |
| 20 | Constitu-tive protease-activated receptor-2-mediated migrationof MDA MB-231 breast cancer cells requires both beta-arrestin-1 and-2 显示文摘 | GE L SHENOY S LE FKOWITZ R J | 2004 | J Biol Chem2004，279，55： | 1 |
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