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| 1 | Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats显示文摘AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells(PBMCs) were isolated from the modeled rats, and cultured with γ-secretase inhibitor DAPT and TGF-β inhibitor for 24 h. The m RNA levels of Notch and TGF-β signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-β proteins was analyzed by western blotting.RESULTS Compared to control rats, Notch and TGF-β signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-β inhibitor suppressed Notch and TGF-β signal transducer in PBMCs of model rats. DAPT reduced m RNA and protein expression of TGF-β signaling, such as TGF-β1 and Smad3. TGF-β inhibitor also downregulated Notch1, Hes1 and Hes5, and m RNA and protein expression of the Notch signaling pathway.CONCLUSION Notch and TGF-β signaling play a role in liver fibrosis. TGF-β signaling upregulates Notch signaling, which promotes TGF-β signaling. | Yi Wang Ruo-Wu Shen Bing Han Zhen Li Le Xiong Feng-Yu Zhang Bei-Bei Cong Bei Zhang | 2017 | World Journal of Gastroenterology2017，23，13： | 25 |
| 2 | Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance显示文摘AIM To investigate the hepatitis C virus(HCV)infection in the tissues of carcinoma ofextrahepatic bile duct and study theircorrelation.METHODS HCV NS5 protein and HCV RNA weredetected by labeled streptavidin biotin(LSAB)method and in situ reverse transcriptionpolymerase chain reaction(IS-RT-PCR)insections of 51 cases of carcinoma ofextrahepatic bile duct and 34 cases of controlgroup(without malignant biliary disease).RESULTS In 51 cases of carcinoma ofextrahepatic bile duct,HCV NS5 protein wasdetected in 14(27.5%),which was clearlystained in the cytoplasm of cancer cell but not inthe nucleus or cell membrane.HCV RNA wasdetected in 18(35.4%),which was located inthe nucleus of cancer cell in 12 cases and in thecytoplasm in 6 cases.HCV NS5 protein and RNAcoexistence was found in 2 cases.In 34 cases ofcontrol group,HCV RNA was detected in 2(5.9%).HCV NS5 protein and RNA positive cellswere found either scattered or in clusters.CONCLUSION The prevalence of hepatitis C viral infection in the tissues of carcinoma ofextrahepatic bile duct was significantly higherthan in control group(X^2=9.808,P=0.002).The findings suggest a correlation between HCVinfection and carcinoma of extrahepatic bileduct,which is different from the traditionalviewpoint.HCV infection might be involved inthe development of carcinoma of extrahepaticbile duct. | Ming Yi Chen Zhi Qiang Huang Le Zhen Chen Ya Bing Gao Rui Yun Peng De Wen Wang | 2000 | World Journal of Gastroenterology2000，6，6： | 19 |
| 3 | Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer显示文摘AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29(EORTC QLQ-CR29) in Chinese patients with colorectal cancer(CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire(EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale(KPS). The reliability and validity of the questionnaires were assessed by Cronbach's α coefficient, the Spearman correlation test and Wilcoxon rank sum test.RESULTS The EORTC QLQ-CR29 showed satisfactory reliability(α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability(α = 0.608). The multitrait scaling analyses showed good convergent(r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups(KPS ≤ 80; KPS > 80). body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients. | Jin-bo Lin Lei Zhang Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang Qia-Qia Li xue-Ying Zhang Yun-Feng Zhang Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei | 2017 | World Journal of Gastroenterology2017，23，10： | 12 |
| 4 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 5 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 6 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 7 | Surface acoustic wave humidity sensors based on uniform and thickness controllable graphene oxide thin films formed by surface tension显示文摘Graphene oxide(GO)is a promising candidate for humidity sensing,and the uniformity and thickness of GO films are important for the reproducibility and test signal strength of humidity sensors.In this paper,uniform and thicknesscontrollable GO films are first formed by the surface tension of different concentrations of GO solution and then transferred to surface acoustic wave(SAW)humidity sensors.This GO film formation and transfer process has very good repeatability and stability,as evidenced by the humidity response of the sensors.With the help of the uniform and highly oxidized GO film,the humidity sensors show a significantly high sensitivity(absolute sensitivity of 25.3 kHz/%RH and relative sensitivity of 111.7 p.p.m./%RH)in a wide test range from 10%RH to 90%RH with very little hysteresis(<1%RH).The sensors achieve good reversibility,excellent short-term repeatability and stability.Moreover,the humidity sensors also show a fast response and recovery time of<10 s. | Xianhao Le Yihan Liu Li Peng Jintao Pang Zhen Xu Chao Gao Jin Xie | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 8 | Neuroprotective effects of Asiaticoside显示文摘In the central nervous system, Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to β-amyloid. In vivo studies demonstrated that Asiaticoside could attenuate neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion animals. In addition, Asiaticoside showed anxiolytic effects in acute and chronic stress animals. However, its potential neuroprotective properties in glutamate-induced excitotoxicity have not been fully studied. We investigated the neuroprotective effects of Asiaticoside in primary cultured mouse cortical neurons exposed to glutamate-induced excitotoxicity invoked by N-methyl-D-aspartate. Pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax. Asiaticoside pretreatment also attenuated the upregulation of NR2 B expression, a subunit of N-methyl-D-aspartate receptors, but did not affect expression of NR2 A subunits. Additionally, in cultured neurons, Asiaticoside significantly inhibited Ca2+ influx induced by N-methyl-D-aspartate. These experimental findings provide preliminary evidence that during excitotoxicity induced by N-methyl-D-aspartate exposure in cultured cortical neurons, the neuroprotective effects of Asiaticoside are mediated through inhibition of calcium influx. Aside from its anti-oxidant activity, down-regulation of NR2B-containing N-methyl-D-aspartate receptors may be one of the underlying mechanisms in Asiaticoside neuroprotection. | Feng-yan Qi Le Yang Zhen Tian Ming-gao Zhao Shui-bing Liu Jia-ze An | 2014 | Neural Regeneration Research2014，9，13： | 3 |
| 9 | Relationship between lipidslevelsand right ventricular volume overload in congestive heart failure显示文摘在类脂化合物和冠的动脉疾病之间的 BackgroundThe 关系很好被建立了。然而,这在类脂化合物和心失败之间不是事实。讽刺地,高类脂化合物层次充分在心失败与更好的结果被联系,但是位于现象下面的机制不是理解。这研究被执行到由于静脉的拥挤减少了肠的类脂化合物吸收的假设可以导致的测试低类脂化合物 levels.MethodsWe 与充血的心失败在 442 个 unselected 病人收集了临床的特征, echocardiograph,和类脂化合物侧面的数据。在类脂化合物层次之间的关联[包括的全部的胆固醇( TCL ),高密度的脂蛋白胆固醇(高级数据链路控制),低密度的脂蛋白胆固醇( LDL-C ),和 triglycerides ( TG )]并且正确的室结束心脏舒张的直径( RVEDD ),左室结束心脏舒张的直径( LVEDD ),正确中庭直径( RA ),左中庭直径( LA ),或左室喷射部分( LVEF )用皮尔森关联和部分关联被分析。RVEDD, LVEDD, RA,和 LA 被索引到身体表面 area.ResultsThere 是在 TCL 层次和 RVEDD 之间的显著地反的关联(r =− 0.34, P <0.001 ) 并且 RA (r =− 0.36, P <0.001 ) 。象 LDL-C,高级数据链路控制,和 TG 那样的另外的类脂化合物与 RVEDD 和 RA 有类似的反的关联。在好久调整以后未改变的仍然是的所有这些关联,性,吸烟地位,物理活动层次, comorbidities,和药 use.ConclusionsLipid 层次相反地与充血的心失败在病人被相关到 RVEDD;然而,因为这是观察研究,进一步的调查被需要验证我们的结果以及如果有的话识别一种原因的关系。 | Ying CHEN Xiao-Mei HE Hong MENG Qing-Zhen ZHAO Yu-Zhi ZHEN Li TIAN Le WANG Li-Shuang JI Guo-Ping MA Yu TIAN Gang LIU Zhen-Guo JI Kun-Shen LIU Chao LIU | 2014 | Journal of Geriatric Cardiology2014，11，3： | 3 |
| 10 | Cobalt and nitrogen codoped porous carbon as superior bifunctional electrocatalyst for oxygen reduction and hydrogen evolution reaction in alkaline medium显示文摘Cobalt and nitrogen codoped carbon materials(Co-N-C) were fabricated by pyrolysis of the mixture of poly(4-vinylpyridine) and cobalt chloride using SiO_2 nanoparticles as hard template, which were the first transition metal/nitrogen-codoped carbon bifunctional electrocatalyst derived from noncarbonizable polymer for ORR and HER. The as-made Co-N-C possessed hierarchical pore structure and high specific surface area, achieving excellent electrocatalytic performances for ORR and HER. Its ORR catalytic performances were comparable to those of Pt/C catalyst and its HER catalytic performances were superior to those of most doped carbon catalysts in KOH electrolyte. Moreover, its bifunctional electrocatalytic performances for ORR and HER were better than those of most bifunctional doped carbon catalysts in alkaline electrolyte. | Xiaoxia Chen Xiangjun Zhen Hongyu Gong Le Li Jianwei Xiao Zhi Xu Deyue Yan Guyu Xiao Ruizhi Yang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 11 | A fast boundary protection for an AC transmission line connected to an LCCHVDC inverter station显示文摘For AC transmission lines connected to an LCC-HVDC inverter station,commutation failure can lead to the wrong operation of traditional protection.To solve the problem,this paper proposes a fast protection scheme using transient information from one end of the AC line.The boundary frequency characteristics of the AC line connected to LCC-HVDC inverter are analyzed first.This reveals the existence of significant attenuation on both high frequency signals and some specific frequency signals.Based on the boundary characteristics,a novel boundary protection principle utilizing a backward traveling wave is then proposed.A PSCAD/EMTDC simulation model of a±800 kV LCC-HVDC and 500 kV AC transmission system is established,and different fault cases are simulated.The simulation results prove that the novel protection principle is immune to commutation failure,fault resistance and fault type. | Zhen Liu Houlei Gao Sibei Luo Le Zhao Yuyao Feng | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 2 |
| 12 | [Bmim]Br_3 as a New Reagent for Regioselective Mono-bromination of Activated Aromatics under Solvent-free Conditions显示文摘Reaction of activated aromatics containing phenols, naphthol, methoxynaphthalenes, anisole etc. with 1-butyl-3-methylimidazolium tribromide ([Bmim]Br3) under solvent-free conditions, selectively gave the corresponding monobromination products with excellent yields. | Zhang Gao LE Zhen Chu CHEN Yi HU Qin Guo ZHENG | 2005 | Chinese Chemical Letters2005，16，8： | 2 |
| 13 | Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons显示文摘 | Le Yang Zhi-ming Yang Nan Zhang Zhen Tian Shui-bing Liu Ming-gao Zhao | 2014 | Molecular and Cellular Biochemistry . 2014 (1-2)2014，，1： | 2 |
| 14 | Comparison of the Prevalence and Characteristics Between EWGSOP1-and EWGSOP2-defined Sarcopenia in Patients with Colorectal Cancer显示文摘Background Sarcopenia,as diagnosed by the former EWGSOP1 guidelines,was prevalent in cancer patients.The aim of this study was to examine the diagnostic capabilities of the previous and current guidelines,and to compare the clinicopathological features between patients diagnosed using the algorithms comprising the EWGSOP1 and EWGSOP2 guidelines.Methods We conducted a study including colorectal cancer patients from July 2014 to July 2019.The skeletal muscle mass,muscle attenuation,handgrip strength,and 6-meter usual gait speed were prospectively measured to define sarcopenia once patients were hospitalized.Results Of a total of 840 patients,160(19.0%)patients were diagnosed with sarcopenia based on the EWGSOP1 and 241(28.7%)patients were diagnosed based on the EWGSOP2.The numbers of patients diagnosed with sarcopenia and severe sarcopenia were much higher when the EWGSOP2 guidelines were used(160 vs.241 and 74 vs.140,respectively).The patients with EWGSOP2-defined sarcopenia showed a lower plasma albumin concentration(37.4 vs.36.4,P=0.039)but higher BMI(21.01 vs.22.22,P<0.001)than the patient diagnosed based on the EWGSOP1 guidelines.Conclusion The diagnosis of sarcopenia based on screening using the EWGSOP1 and EWGSOP2 guidelines differs considerably,at least in patients with colorectal cancer.In addition,the patients with EWGSOP2-diagnosed sarcopenia also showed a trend toward a lower plasma albumin level and higher BMI. | Feng Min Zhang Zhen Yu Han Ping Shi Cheng Le Zhuang | 2020 | Journal of Nutritional Oncology2020，5，1： | 2 |
| 15 | Contribution of Temperature Increase to Restrain the Transmission of COVID-19显示文摘The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still under discussion.Here,we elucidated these relationships by utilizing two unique scenarios,repeated measurement and natural experiment,using the COVID-19 cases reported from January 23–February 21,2020,in China.The modeling results revealed that higher temperature was most strongly associated with decreased COVID-19 transmission at a lag time of 8 days.Relative humidity(RH)appeared to have only a slight effect.These findings were verified by assessing SARSCoV-2 infectivity under the relevant conditions of temperature(4C–37C)and RH(>40%).We concluded that temperature increase made an important,but not determined,contribution to restrain the COVID19 outbreak in China.It suggests that the emphasis of other effective controlling polices should be strictly implemented to restrain COVID19 transmission in cold seasons. | Mengyuan Ren Rongjuan Pei Bahabaike Jiangtulu Junxi Chen Tao Xue Guofeng Shen Xiaoru Yuan Kexin Li Changxin Lan Zhen Chen Xinwen Chen Yun Wang Xiaoqian Jia Zewu Li Audil Rashid Tippawan Prapamontol Xiuge Zhao Zhaomin Dong Yali Zhang Le Zhang Rongwei Ye Zhiwen Li Wuxiang Guan Bin Wang | 2021 | The Innovation2021，2，1： | 2 |
| 16 | Blue AIEgens bearing triphenylethylene peripheral:adjustable intramolecular conjugation and good device performance显示文摘The new approaches to construct deep blue aggregation-induced emission(AIE) materials have been explored, which control the conjugation by two different strategies, to make a great step for the commercialization of organic light-emitting diodes. In order to shorten the intramolecular conjugation length, triphenylethylene(t PE)was utilized to construct blue AIEgens as peripheral groups,instead of tetraphenylethylene(TPE), the famous AIE star molecule, to yield three blue AIEgens of 3,4-Bt PE-PI, 4,4-Bt PE-PI and 4,4-Bt PE-PPI. Nondoped electroluminescence devices are fabricated by using these three AIEgens as the emitting material layer, the best performance of 3.8 cd/A as the maximum current efficiency achieved at the commission internationale de l'Eclairage coordinates of(0.17, 0.18). | Can Wang Le Li Xuejun Zhan Zhijun Ruan Yujun Xie Quanyuan Hu Shanghui Ye Qianqian Li Zhen Li | 2016 | Science Bulletin2016，61，22： | 2 |
| 17 | Racial/ethnic differences in influenza vaccination coverage in high - risk adults显示文摘 | Egede LE Zhen D | 2003 | Am J Public Health2003，93，12： | 1 |
| 18 | Grafting of Hexafluoropropylene onto Polytetramethylene Glycol by Radical Reaction显示文摘A well-defined modification of polytetramethylene glycol (PTMG) was realized by radical grafting with hexafluoropropylene (HFP). The structure of grafted product was confirmed by means of IR, 1H NMR and 13C NMR. The effects of the amount of initiator, reaction time and temperature on the grafting HFP onto PTMG were investigated. | Zhen GE Xing Yuan ZHANG Jia Bing DAI Xiao Le TAO | 2005 | Chinese Chemical Letters2005，16，12： | 1 |
| 19 | A critical review on the technique and mechanism of microwave-based denitrification in flue gas显示文摘Microwave radiation has received extensive attention due to its significant thermal and nonthermal effects, and the development of MW-based denitrification in flue gas has become one of the most promising methods to avoid the defects of ammonia escape, high temperature and cost in traditional SCR. This review introduces the thermal and non-thermal effects of microwaves and divides MW-based denitrification methods into MW reduction and oxidation denitrification, systematically summarizes these denitrification methods, including MW discharge reduction, MW-induced catalytic reduction using active carbon, molecular sieves, metal oxides(transition metals, perovskites, etc.), MW-induced oxidation denitrification with and without additional oxidant, and discusses their removal pathway and mechanism. Finally, several research prospects and directions regarding the development of microwave-based denitrification methods are provided. | Bo Yuan Zhen Qian Zili Zhangc Le Fu Shihang Pan Runlong Hao Yi Zhao | 2022 | Journal of Environmental Sciences2022，34，10： | 1 |
| 20 | Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis显示文摘 | Le Yang Na Chang Xin Liu Zhen Han Tieping Zhu Changyong Li Lin Yang Liying Li | 2012 | The American Journal of Pathology2012，，1： | 1 |
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