|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Rat model of central venous catheter to study establishment of long-term bacterial biofilm and related acute and chronic infections显示文摘 | Chauhan A Lebeaux D Decante B A | | 0，，05： | 1 |
| 3 | Clinical outcome after a totally implantable venous access port-related infection in cancer patients:a prospective study and review of the literature显示文摘 | Lebeaux D Larroque B Gellen-Dautrerner J | 2012 | Medicine (Baltimore)2012，91，6： | 1 |
| 4 | Clinical outcomeafter a totally implantable venous access port-related infectionin cancer patients: a prospective study and review of theliterature显示文摘 | Lebeaux D Larroque B Gellen-Dautremer J | 2012 | Medicine (Baltimore)2012，91，6： | 1 |
| 5 | Clinical outcome after a totally implantable venous access port-related infection in cancer patients 显示文摘 | Lebeaux D Larroque B Gellen-Dautremer J | 2012 | Medicine (Baltimore)2012，91，： | 1 |
| 6 | Manage- ment of infections related to totally implantable venous - accessports:challenges and perspectives显示文摘 | Lebeaux D Fernandez - Hidalgo N Chauhan A | 2014 | Lancet Infect Dis2014，14，2： | 1 |
| 7 | The effects of methylene blue on neural tissue显示文摘 | POPPERS P J MASTRI A R LEBEAUX M L | 1970 | Anesthesiology1970，33，： | 1 |
| 8 | Therapeutic drug monitoring of posaconazole:a monocentric study with 54adults显示文摘 | Lebeaux D Lanternier F Elie C | 2009 | Antimicrob Agents Chemother2009，53，12： | 1 |
| 9 | Starvation, together with the SOS response, mediates high biofilm - specific tolerance to the flu- oroquinolone ofloxacin 显示文摘 | Bernier SP Lebeaux D Defrancesco A S | 2013 | PLoS Genet2013，9，1： | 1 |
| 10 | Locality and anaphoric binding显示文摘 | Lebeaux D | 1984 | The Linguistic Review1984，，4： | 1 |
| 11 | Clinical outcome after a totally implantable venous access port-related infection in cancer patients:a prospective study and review of the literature显示文摘 | Lebeaux D Larroque B Gellen-Dautremer J | 2012 | Medicine(Baltimore)2012，91，6： | 1 |
| 12 | A rat model of central ve- nous catheter to study establishment of long-term bacterial biofihn and related acute and chronic infections 显示文摘 | Chauhan A Lebeaux D Decante B | 2012 | PLoS One2012，7，37： | 1 |
| 13 | High prevalence of the arginine catabolic mobile element in carriage isolates of methicillin - resistant Staphylococcus epidermidis 显示文摘 | Barbier F Lebeaux D Hernandez D | 2011 | J Antimicrob Chemother2011，66，1： | 1 |
| 14 | A rat model of central ve- nous catheter to study establishment of long-term bacterial biofihn and related acute and chronic infections 显示文摘 | Chauhan A Lebeaux D Decante B | 2012 | PLoS One2012，7，37： | 1 |
| 15 | Clinical outcome after a totally implantable venous access port-related infection in cancer patients: a prospective study and review of the literature显示文摘 | Lebeaux D Larroque B Gellen-Dautremer J et at | 2012 | Medicine (Baltimore)2012，91，6： | 1 |
| 16 | Therapeutic drug monito- ring of posaconazole : a monocentric study with 54 adults 显示文摘 | Lebeaux D Lanternier F Elie C | 2009 | Antimicrob Agents Chemother2009，53，12： | 1 |
| 17 | Evolution of na- sal carriage of methicillin-resistant coagulase-negative staphy- lococci in a remote population显示文摘 | Lebeaux D Barbier F Angebault C | 2012 | Antimierob Agents Che- mother2012，56，1： | 1 |
| 18 | Long term central venous cathete~related infections 显示文摘 | Lebeaux D Joly D Zahar J R | 2014 | Rev Prat2014，64，5： | 1 |
| 19 | From in vitro to in vivo models of bacterial biofilm-related infections显示文摘 | Lebeaux D Chauhan A Rendueles O | 2013 | Pathogens2013，2，2： | 1 |
| 20 | Management of infections related to totally implantable venous-access ports: challenges and perspectives 显示文摘 | Lebeaux D Fernandez-Hidalgo N Chauhan A | 2014 | Lancet Infect Dis2014，14，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员