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| 1 | 浅议大学英语教学中学生跨文化交际能力的培养显示文摘大学英语教学不仅是要教给学生语言知识,培养其听说读写等应用技能,还要着力培养学生跨文化交际的能力。培养大学生跨文化交际能力的路径和方法是:利用现有教材,培养大学生的跨文化意识;在课堂教学中利用对比法、实物讲授法、任务教学法、讨论法和直观法等教学方法,以及在课外活动中,培养大学生的跨文化交际能力;教师要增强自身的跨文化意识,提高教学水平。 | 乐琼 Chauhan Ashok Kumar | 2010 | 教育探索2010，，8： | 31 |
| 2 | 不同沙棘籽提取物的抗氧化和抗菌活性研究显示文摘使用Soxhlet提取装置,用氯仿、乙酸乙酯、丙酮、甲醇4种不同溶剂对沙棘籽分别进行8小时萃取。粗提物被用来进行抗氧化和抗菌活性筛选。在离体模型(清除DPPH自由基和脂质体模型系统)中的粉末减少和抗氧化活性评价显示在各种提取物中使用甲醇作为萃取剂的提取物具有最高的抗氧化活性。甲醇提取物也具有最高的抗菌活性。最低抑制浓度(MIC)评价显示,在加入甲醇提取物对蜡状芽孢杆菌、凝结芽孢杆菌、枯草芽孢杆菌、单核细胞增生利斯特菌、小肠结肠炎耶尔森氏菌进行培养,MIC浓度分别为200,300,300,300,和350ppm。研究结果表明,沙棘种子应用于医药和食品储藏。 | P. S. Negi A. S. Chauhan G. A. Sadia Y. S. Rohinishree R. S. Ramteke 郭海 郭敏 | 2006 | 国际沙棘研究与开发2006，4，1： | 11 |
| 3 | 仙茅:对健康有众多益处的黑金(英文)显示文摘仙茅(石蒜科)是一种濒临灭绝的多年生草本植物,是印度本土药,作为强有力的适应原和春药在印度传统药物中占有重要位置。它也是多种印度传统药物处方的重要组成部分,被认为具有促进性欲、刺激免疫、保护肝脏、抗氧化、抗癌和治疗糖尿病等作用。已有报道,从仙茅中提取出多种化学成分,如植物黏胶,酚苷、皂苷和脂肪族化合物等。仙茅也是中医和日本汉方医学中各种草药处方的重要成分。本文对仙茅的多种生物活性和其不同化学成分的作用进行了综述。 | Nagendra Singh Chauhan Vikas Sharma Mayank Thakur Vinod Kumar Dixit | 2010 | 中西医结合学报2010，8，7： | 6 |
| 4 | Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents显示文摘Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.These are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical era.Alongside,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with nanodiamonds.Surface modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface chemistry.To take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological environment.This review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of nanodiamonds.For the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces. | Swati Chauhan Neha Jain Upendra Nagaich | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 5 |
| 5 | Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management显示文摘Chronic hepatitis B(CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma(HCC). Liver transplantation(LT) is considered gold standard for treatment of hepatitis B virus(HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin(HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressingviral replication and improving long-term survival. The combination of lamivudine(LAM) plus HBIG has been for many years the most widely used. However, life-long HBIG use is both cumbersome and costly, whereas long-term use of LAM results in resistant virus. Recently, in an effort to develop HBIG-free protocols, high potency nucleos(t)ide analogues, such as Entecavir or Tenofovir, have been tried either as monotherapy or in combination with low-dose HBIG with excellent results. Current focus is on novel antiviral targets, especially for covalently closed circular DNA(ccc DNA), in an effort to eradicate HBV infection instead of viral suppression. However, there are several other molecular mechanisms through which HBV may reactivate and need equal attention. The purpose of this review is to address post-LT HBV reactivation, its risk factors, underlying molecular mechanisms, and recent advancements and future of anti-viral therapy. | Ranjit Chauhan Shilpa Lingala Chiranjeevi Gadiparthi Nivedita Lahiri Smruti R Mohanty Jian Wu Tomasz I Michalak Sanjaya K Satapathy | 2018 | World Journal of Hepatology2018，10，3： | 5 |
| 6 | Magnesium based implants for functional bone tissue regeneration–A review显示文摘Magnesium(Mg)has emerged as one of the third-generation biomaterials for regeneration and support of functional bone tissue.Mg is a better choice over permanent implants such as titanium,stainless steel,cobalt-chrome as magnesium is biodegradable and does not require a second surgery for its removal after bone tissue recovery.It also reduces the risk of stress shielding as its elastic modulus is closer to human bone in comparison to permanent implants and other biodegradable metallic implants based on Iron and Zinc.Most importantly,Mg is osteoconductive thus stimulates new bone formation and possess anti-bacterial properties hence reducing the risk of failure due to infection.Despite its advantages,a major concern with pure Mg is its rapid bio-corrosion in presence of body fluids due to which the mechanical integrity of the implant deteriorates before healing of the tissue is complete.Mechanical properties of Mg-based implants can be enhanced by mechanical processing,alloying,and topology optimization.To reduce the corrosion/degradation rate,Mg has been alloyed with metals,reinforced with ceramics,and surface coatings have been applied so that the degradation rate of Mg-based implant matches with that of healing rate of bone tissue.The present review discusses the effect of alloying elements and reinforcing ceramics on microstructure,mechanical,and corrosion properties of Mg-based orthopedic implants.In addition,the biocompatibility of Mg-based alloys,composites,and coatings applied on Mg implants has been highlighted.Further,different methods of fabricating porous implants have been highlighted as making the implant porous facilitates the growth of new bone tissue through the pores. | Gavish Uppal Amit Thakur Amit Chauhan Saroj Bala | 2022 | Journal of Magnesium and Alloys2022，10，2： | 4 |
| 7 | Identification and characterization of genotype A and D recombinant hepatitis B virus from Indian chronic HBV isolates显示文摘AIM: To confirm the presence of recombination,full-length hepatitis B virus (HBV) from chronic patients was sequenced and analyzed.METHODS: Full-length HBV genomes from 12 patients were amplified and sequenced in an automated sequencer.Phylogenetic analysis was carried out on full-length,Core and preS2/Surface regions using MEGA software.SimPlot Boot Scanning and amino acid sequence analysis were performed for confirmation of recombination.RESULTS: Eight patients were infected with genotype D strain; one patient with genotype A and three patients had genotype A and D recombination; two of them had cirrhosis and one had hepatocellular carcinoma.Phylogenetic analysis of core and preS2/surface regions separately showed evidence of genotype A and D recombination.The breakpoints of recombination were found to be at the start of preS2 and at the end of surface coding regions.CONCLUSION: We identified and characterized recombinant A and D genotype HBV in hepatitis B surface antigen (HBsAg)-positive patients. | Ranjit Chauhan Syed Naqui Kazim Manoj Kumar Jayashree Bhattacharjee Narayanasamy Krishnamoorthy Shiv Kumar Sarin | 2008 | World Journal of Gastroenterology2008，14，40： | 4 |
| 8 | Efficient CAN catalyzed synthesis of 1H-indazolo[1,2-b] phthalazine-1,6,11-triones:An eco-friendly protocol显示文摘A convenient,economical and green approach to the synthesis of 1H-indazolo[1,2-b]phthalazine-1,6,11-trione derivatives has been achieved via a one-pot protocol using phthalhydrazide,a cyclic-β-diketone and an aldehyde in the presence of a ceric ammonium nitrate catalyst in polyethylene glycol.The simple work up,mild conditions,excellent yields,inexpensive and non-toxic catalyst and simple solvent recyclability render this protocol both attractive and economically viable. | MAZAAHIR Kidwai RITIKA Chauhan ANWAR Jahan | 2012 | Chinese Science Bulletin2012，57，18： | 3 |
| 9 | 搅拌铸造制备新型Al2024/SiC/赤泥复合材料的特性和抗拉强度(英文)显示文摘采用搅拌铸造技术制备SiC颗粒(5%,质量分数)和赤泥(5%~20%,质量分数)颗粒增强2024铝基复合材料。利用扫描电子显微镜(SEM)和电子能谱(EDS)技术表征合成的复合材料;另外,利用Taguchi实验设计方法测试混杂复合材料的抗拉强度。结果表明,混杂复合材料中的增强颗粒分散均匀,结合充分;复合材料的密度和孔隙率随着增强体含量的增加而降低,抗拉强度随着赤泥含量和时效时间的增加而增加;复合材料中赤泥含量对抗拉强度影响最大,其次是时效时间。总体来说,与基体材料Al2024铝合金相比,铝合金/SiC/赤泥复合材料在优化条件下具有更优异的抗拉强度(高34%)。 | Jaswinder SINGH Amit CHAUHAN | 2017 | Transactions of Nonferrous Metals Society of China2017，27，12： | 3 |
| 10 | Rituximab in kidney disease and transplant显示文摘Rituximab is a chimeric monoclonal antibody that binds to CD20 antigen of B‐cells. It depletes the level of mature B‐cells by various mechanisms such as mediation of antibody‐ dependent cellular cytotoxicity, complement‐dependent cytotoxicity, and B‐cell apoptosis. Rituximab is a USFDA approved drug for clinical use in non‐Hodgkin's B‐cell lymphoma (NHL), rheumatoid arthritis, chronic lymphocytic leukemia (CLL), granulomatosis with polyangiitis and pemphigus vulgaris. It is also known for its “off label” use in renal disease and renal transplant worldwide. However, the exact mechanisms by which it exerts its effect in the aforementioned condition remain unclear but may be related to its long‐term effects on plasma cell development and the impact on B‐cell modulation of T cell responses. This review discusses the current use of rituximab in renal disease and renal transplantation, and its potential role in novel therapeutic protocols. | Kajal Chauhan Anita A. Mehta | 2019 | Animal Models and Experimental Medicine2019，2，2： | 3 |
| 11 | Bystanders or not?Microglia and lymphocytes in aging and stroke显示文摘As the average age of the world population increases,more people will face debilitating aging-associated conditions,including dementia and stroke.Not only does the incidence of these conditions increase with age,but the recovery afterward is often worse in older patients.Researchers and health professionals must unveil and understand the factors behind age-associated diseases to develop a therapy for older patients.Aging causes profound changes in the immune system including the activation of microglia in the brain.Activated microglia promote T lymphocyte transmigration leading to an increase in neuroinflammation,white matter damage,and cognitive impairment in both older humans and rodents.The presence of T and B lymphocytes is observed in the aged brain and correlates with worse stroke outcomes.Preclinical strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged subjects.In this review,we examine the role of the microglia and T and B lymphocytes in aging and how they contribute to cognitive impairment.Additionally,we provide an important update on the contribution of these cells and their interactions in preclinical aged stroke. | Justin N.Nguyen Anjali Chauhan | 2023 | Neural Regeneration Research2023，18，7： | 3 |
| 12 | Evaluation of Cytogenetic Effects of Isoproturon on the Root Meristem Cells of Allium sativum显示文摘Objective\ To validate the use of Allium sativum as a reliable test model for genotoxicity, isoproturon, a substituted phenylalkylurea herbicide, was evaluated on the root meristem cells by this plant system. Method\ Test concentrations were selected by determining EC50 and root tips were exposed to various concentrations for 6 or 24 hr. EC50 concentration was calculated to be 70.8 ppm for the root growth. In addition to root growth retardation exposure to isoproturon induced morpholoogical changes like discolouration and stiffness of roots. Results\ Exposure to various experimental concentrations of isoproturon (35-280 ppm), including EC50, significantly and dose-dependently inhibited the mitotic index and induced chromosome breaks/mitotic aberrations at 6 or 24 hr. Conclusion\ The frequency of aberrations was found to be decreased in a dose dependant manner at 24 or 48 hr post exposure, however in comparison of control cells the frequency of aberrations was considerably high which indicates genotoxicity potentials of isoproturon. Further, present study also suggests that Allium sativum is a sensitive, efficient, and reliable test system for measuring the genotoxicity potential of environmental chemicals. | L. K. S. CHAUHAN, P. N. SAXENA, AND S. K. GUPTA1Cell Biology Section, Industrial Toxicology Research Centre, P. B. No. 80, M. G. Marg, Lucknow- 226001, India\ \ | 2001 | Biomedical and Environmental Sciences2001，14，3： | 3 |
| 13 | siRNA-mediated downregulation of TC21 sensitizes esophageal cancer cells to cisplatin显示文摘AIM:To determine the functional significance of TC21 in esophageal squamous cell carcinoma(ESCC).METHODS:TC21 siRNA transfection was carried out using Hyperfectamine to knock down TC21,and transcripts were analyzed by reverse transcription-polymerase chain reaction and protein by Western blotting.We demonstrated the effect of TC21 downregulation of cell signaling in esophageal cancer cells by assessing the phosphorylation status of its downstream targets,phosphoinositide 3-kinase(PI3K),phosphatase and tensin homolog(PTEN),protein kinase B(pAkt),nuclear factor-B(NF-B) and cyclinD1 using specific antibodies.Cell survival analysis after cisplatin treatment was carried out by cell viability assay and cell cycle analysis using flow cytometry.RESULTS:TC21 knockdown in human ESCC cell line TE13 cells,showed only a marginal increase(14.2%) in cell death compared with control cells.The expressions of the signaling proteins PI3K and pAkt,transcription factor NF-B,and cell cycle protein cyclin D1 were markedly decreased in response to TC21 downregulation,whereas the level of pPTEN,an antagonist of PI3K,was increased.In addition,we evaluated the potential of TC21 as a putative target for sensitizing ESCC cells to the chemotherapeutic agent cisplatin.Increased cell death(38.4%) was observed in cells treated with cisplatin after TC21 knockdown compared with cells which were treated with cisplatin alone(20% cell death).CONCLUSION:Results suggest that TC21 mediates its effects via the PI3K-Akt pathway,NF-B and cyclin D1,and enhances chemoresistance in esophageal cancer cells. | Md.Raghibul Hasan Shyam Singh Chauhan Rinu Sharma Ranju Ralhan | 2012 | World Journal of Gastroenterology2012，18，31： | 3 |
| 14 | Ayurvedic concept of Shatkriyakala:a traditional knowledge of cancer pathogenesis and therapy显示文摘The term Kriyakala refers to the recognition of the stage of a disease's progress,which helps to determine appropriate measure to correct the imbalance in Doshas(biological factors).It is a compound expression,comprised of Kriya and Kala,where Kriya means the choice to treatment(medicine,food and daily-routine) used to improve the disturbance in Doshas,and Kala refers to the stage of progress of a disease.Sushruta,an ancient Indian surgeon,has described the concept of Kriyakala in Varnaprashnadhyaya,an ancient Vedic Sanskrit text,which seeks to explain the incidence of Varnas in terms of Doshic disturbances.Varna,in modern parlance,may be described as an inflammatory process that may lead ulceration and chronic inflammation,promoting all stages of carcinogenesis.Abnormal interactions between Prakriti(genotype) and environmental factors vitiate the Doshas and impair immunity,which can lead to aberrant cell growth and cancer.Moreover,the interaction between vitiated Doshas and weak Dhatus(body tissues) manifests as cancers of a specific organ.Shatkriyakala(six stages of progress of a disease),on the other hand,provides a framework to assess the cancer and its pathogenesis in different stages.According to Ayurvedic concepts,all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas,rejuvenating Dhatus and restoring immunity in cancer patients.The present review describes the six stages of Shatkhyakala in detail,with an emphasis on research areas to validate the concept of Shatkhyakala.This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages. | Ashutosh Chauhan Deepak Kumar Semwal Satyendra Prasad Mishra Ruchi Badoni Semwal | 2017 | Journal of Integrative Medicine2017，15，2： | 3 |
| 15 | Nutrition in alcohol-related liver disease:Physiopathology and management显示文摘Malnutrition encompassing both macro-and micro-nutrient deficiency,remains one of the most frequent complications of alcohol-related liver disease(ArLD).Protein-energy malnutrition can cause significant complications including sarcopenia,frailty and immunodepression in cirrhotic patients.Malnutrition reduces patient’s survival and negatively affects the quality of life of individuals with ArLD.Moreover,nutritional deficit increases the likelihood of hepatic decompensation in cirrhosis.Prompt recognition of at-risk individuals,early diagnosis and treatment of malnutrition remains a key component of ArLD management.In this review,we describe the pathophysiology of malnutrition in ArLD,review the screening tools available for nutritional assessment and discuss nutritional management strategies relevant to the different stages of ArLD,ranging from acute alcoholic hepatitis through to decompensated end stage liver disease. | Umair Kamran Jennifer Towey Amardeep Khanna Abhishek Chauhan Neil Rajoriya Andrew Holt | 2020 | World Journal of Gastroenterology2020，26，22： | 3 |
| 16 | A study on the performance and emission of a diesel engine fueled with Jatropha biodiesel oil and its blends显示文摘 | Bhupendra Singh Chauhan Naveen Kumar Haeng Muk Cho | 2011 | Energy2011，，1： | 2 |
| 17 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 18 | Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer显示文摘 | Nidhi Singh Prasenjit Das Siddhartha Datta Gupta Peush Sahni R. M. Pandey Surabhi Gupta Shyam S. Chauhan Anoop Saraya | 2013 | Cancer Investigation2013，，7： | 2 |
| 19 | Milk exosomes:Nature’s abundant nanoplatform for theranostic applications显示文摘Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles.Exosomes have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological processes.Among various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications.To be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking characteristics.Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications.This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches.It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents.This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle. | Benilde Adriano Nycol M.Cotto Neeraj Chauhan Meena Jaggi Subhash C.Chauhan Murali M.Yallapu | 2021 | Bioactive Materials2021，6，8： | 2 |
| 20 | 白念珠菌SSK1突变株对氟康唑敏感性的初步研究显示文摘目的探讨氟康唑作用于白念珠菌双组分信号传导途径SSK1突变株SSK21后药物敏感性的变化。方法采用微量液体稀释法和固醇测定法测定野生株(CAF2-1)和突变株(SSK21)的最小抑菌浓度(MIC);并应用RT-PCR观察氟康唑作用前后,SSK1的表达变化。结果氟康唑对CAF2-1的MIC为16μg/mL,对SSK21为0.032μg/mL。加入氟康唑后,CAF2-1的SSK1表达明显增加,60min时达到最多。结论 SSK21对氟康唑高度敏感,SSK1基因及其相关的重要基因与药物敏感性的关系值得进一步研究,从而为新的抗真菌药物和治疗途径的研发提供参考。 | 李筱芳 Neeraj Chauhan Richard Calderone 刘维达 | 2010 | 中国真菌学杂志2010，5，5： | 2 |
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