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您的检索式：作者名="Lederer DE"
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| 1 | Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats显示文摘Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury(SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein(GFAP) and S100 calcium-binding protein B(S100B)(astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats(aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases(first phase: no changes in the 6, 24 and 48 hours post-SCI groups; second phase: increased levels in the 72 hours post-SCI group; and a third phase: return to levels similar to control in the 7 days post-SCI group). Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury. | Mayara Ferraz de Menezes Fabricio Nicola Ivy Reichert Vital da Silva Adriana Vizuete Viviane Rostirola Eisner Leder Leal Xavier Carlos Alberto Saraiva Goncalves Carlos Alexandre Netto Regis Gemerasca Mestriner | 2018 | Neural Regeneration Research2018，13，11： | 2 |
| 2 | Thiamine pyrophosphate, a coenzyme of transketolase 显示文摘 | RACKER E DE LA HABA G LEDER I G | 1953 | J Am Chem Soc1953，75，： | 1 |
| 3 | Use of fundus auto- fluorescence images to predict geographic atrophy progression 显示文摘 | Bearelly S Khanifar AA Lederer DE | 2011 | Retina2011，31，1： | 1 |
| 4 | Comparison of color fundus photographs and fundus autofluorescence images in measuring geographic atrophy area显示文摘 | Khanifar AA Lederer DE Ghodasra JH | 2012 | Retina2012，32，9： | 1 |
| 5 | Analysis macular volume in normal and glaucomatous eyes using optical coherence tomography显示文摘 | Lederer DE Schmnan JS Hertzmark E | 2003 | Am J ophthalmol2003，135，： | 1 |
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