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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 3 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 4 | 香港渔农业中的鸟类保育显示文摘一场人与鸟的'争食之战'天刚亮,兰姨和丈夫陈生穿上厚衣服离开元朗大生围的家,沿着村的小路朝鱼塘走,天空还积着厚厚乌云,北风劲吹,站在电线杆的白颈鸦却悠然自得,丝毫不惧寒风。沿途的塘壆有几只小白鹭正观察水面的波动。突然,一只黑色的大鸟从水底探出,口中衔着福寿鱼的下半身,兰姨说道:'又是鸬鹚在偷鱼吃!'。 | 罗伟仁 Evans Leung(摄影) Kenny Lee(摄影) CY Wong(摄影) | 2021 | 森林与人类2021，，7： | 2 |
| 5 | Identification of differentially expressed genes in cardiac hypertrophy by analysis of expressed sequence tags显示文摘 | Hwang DM Dempsey AA Lee CY | 2000 | Genomics2000，6，1： | 2 |
| 6 | Optimal cut-off values for obesity:using simple anthropometric indices to predict cardiovascular risk factors in Taiwan显示文摘 | Lee LT Chen CY | 2002 | Int J Obes Relat Metab Disord2002，26，： | 1 |
| 7 | Immunoidentification of gonadotropin releasing hormone receptor in human sperm, pituitary and cancer cells显示文摘 | Lee CY Ho J Chow SN | 2000 | Am J Reprod Immunol2000，44，3： | 1 |
| 8 | Inhibition of colon tumur progression and angiogenesis by the INK4a/Arf locus显示文摘 | Gibson SL Dai CY Lee HW | 2003 | Cancer Res2003，63，4： | 1 |
| 9 | Typing of hantavirus from continents by polymerase chain reaction显示文摘 | Puthavathana P Lee HW Kang Cy | 1992 | Virus Res1992，26，1： | 1 |
| 10 | Glycated albumin activates PAI-1 transcription through Smad DNA binding sites in mesangial cells显示文摘 | Lee HS Moon KC Song CY | 2004 | Am J Physiol Renal Physiol2004，287，4： | 1 |
| 11 | Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occluding,zonula occludens- 1,and claudin-l显示文摘 | Lui WY Lee WM Cheng CY | 2001 | Endocrinology2001，142，5： | 1 |
| 12 | Cesarean scar defect: correlation between Cesarean section number, defect size, clinical symptoms and uterine position 显示文摘 | Wang CB Chiu WW Lee CY | 2009 | Ultrasound Obstet Gyneeol2009，34，： | 1 |
| 13 | Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats显示文摘 | Hsieh FC Lee CL Chai CY | 2013 | Nutr Metab (Lond)2013，10，1： | 1 |
| 14 | Regulafion of microglial phagocytosis and inflammatory gene expression by Cras6 Acting on the Axl/Mer family of tyrosine kinase显示文摘 | Crommes C Lee CY Wfldnson BL | 2008 | Neuroimmune Pharmacol2008，3，2： | 1 |
| 15 | Oxidized lowdensity lipoprotein and oxidat ivestress in the development of glomeru loscleros显示文摘 | Lee HS Song CY | 2009 | Am JN eph ro2009，29，： | 1 |
| 16 | Genetic regulation of the intercellular ad- hesion locus in Staphylococci显示文摘 | Cue D Lei MG Lee CY | 2012 | Front Cell Infect Microbiol2012，26，2： | 1 |
| 17 | Nitric oxide and cyclic nucleotides:their roles in junction dynamics and spermatogenesis显示文摘 | Lee NP Cheng CY | 2008 | Adv Exp Med Biol2008，636，2： | 1 |
| 18 | The efficacy of photodynamic diagnosis in defining the lateral border between a tumor and a tumor-free area during Mohs micrographic surgery 显示文摘 | Lee CY Kim KH Kim YH | 2010 | Dermatol Surg2010，36，11： | 1 |
| 19 | Heteroresistance of Helicobacter pylori from the same patient prior to antibiotic treatment 显示文摘 | Kao CY Lee AY Huang AH | 2014 | Infect Genet Evol2014，23，： | 1 |
| 20 | Lovastatin inhibits oxidized low-density lipoprotein induced plasminogen activator inhibitor and transforming growth factor-betal expression via a decrease in Ras/extracellular signal-regulated kinase activity in mesangial cells显示文摘 | Song CY Kim BC Lee HS | 2008 | Transl Res2008，151，1： | 1 |
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