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| 1 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 2 | Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice显示文摘BackgroundHyperhomocysteine 是冠的心疾病(CHD ) 的一个独立风险因素。然而, hyperhomocysteine 是否影响动脉粥样硬化的前进,是不清楚的。在现在的学习,我们在低密度的脂蛋白在动脉粥样硬化的形成上检验了 hyperhomocysteine 的效果受体缺乏(LDLr −/−) mice.MethodsForty -- 八只 7-week-old LDLr −/− 老鼠被分到下列组:老鼠喂了一本标准啮齿类动物食谱(控制组) ,老鼠喂了一本高蛋氨酸的食谱(高蛋氨酸的组) ,老鼠喂了一本高脂肪的食谱(高脂肪的组) ,并且老鼠在蛋氨酸和脂肪(高蛋氨酸、高脂肪的组) 高喂了一本食谱。在 19, 23,和 27 个星期岁时,在在每个组的每间隔的四个鼠标是 sacrificed.ResultsAt 学习的结束,鼠标没在大动脉的湾穴和大动脉的表面显示出动脉粥样硬化患者损害直到在控制组旧的 27 个星期。然而,动脉粥样硬化患者损害在 19 个星期在另外的三个组发展了。大动脉的表面上的动脉粥样硬化患者损害的数量比在高脂肪的组在高蛋氨酸的组是更低的(P <0.001 ) 。在高蛋氨酸、高脂肪的组的大动脉的表面上的动脉粥样硬化患者损害是最严重的。在大动脉的湾穴的动脉粥样硬化患者损害的吝啬的区域比在高脂肪的组在高蛋氨酸的组与大动脉的表面上的动脉粥样硬化患者损害相比是更低的(P <0.001 ) 。在在高蛋氨酸、高脂肪的组的大动脉的湾穴的动脉粥样硬化患者损害是大多数 severe.ConclusionsHomocysteinemia 加速动脉粥样硬化患者损害并且在 LDLr −/− 老鼠独立地导致早动脉粥样硬化。减少 homocysteinemia 的水平可能为 CHD 的预防和处理是有益的。 | Hang-Yuan GUO Fu-Kang XU Hai-Tao LV Long-Bin LIU Zheng JI Xiao-Ya ZHAI Wei-Liang TANG Ju-Fang CH | 2014 | Journal of Geriatric Cardiology2014，11，1： | 23 |
| 3 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 4 | Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro显示文摘INTRODUCTION Salvianolic radix,one of the most commonly usedtraditional Chinese herbs,was widely studied aboutits actions against liver injury and fibrosis,and wasone of the focuses of recent research.Salvianolic acid-A(SA-A)was an aqueous solublecomponent of Salvianolic radix.In our | Hu YY Liu CH Wang RP Liu C Liu P Zhu DY | 2000 | World Journal of Gastroenterology2000，6，3： | 15 |
| 5 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 6 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 7 | Contour representation based on wedgelet显示文摘Aiming at the shortcomings of the existing wed gelet compression arithmetics, a novel contour-representing algorithm based on wedgelets is presented in this paper. Firstly the input image is binarized and the most optimized wedgelets ar e found by means of quadtree framework. Then the contours are reconstructed by a pplying the wedgelets, the data volume is compressed, and the shortcomings of th e contour representation based on normal wavelet are ameliorated, the better ef fect for the visualization is obtained, too. | Liu Zeyi~1, Sun Ziqiang~ 2,3 , Xu Ling~2 & Peng Xiang~ 4,5 1. Dept. of Mathematics of Science Coll., Shenzhen Univ., Shenzhen 518060, P.R. China 2. Dept. of Mathematics of Science Coll., Tianjin Univ., Tianjin 300072, P.R. Ch ina 3.Tianjin Foreign Studies Univ., Tianjin 300204, P.R. China 4. Inst. of Optoelectronics, Shenzhen Univ., Shenzhen 518060, P.R. China 5. National Lab of Precision Measurement Technology and Instrumentation, Tianjin 300072, P.R. China | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 2 |
| 8 | The Crosstalk of mTOR/S6K1 and Hedgehog Pathways显示文摘 | Yan Wang Qingqing Ding Chia-Jui Yen Weiya Xia Julie G. Izzo Jing-Yu Lang Chia-Wei Li Jennifer L. Hsu Stephanie A. Miller Xuemei Wang Dung-Fang Lee Jung-Mao Hsu Longfei Huo Adam M. LaBaff Dongping Liu Tzu-Hsuan Huang Chien-Chen Lai Fuu-Jen Tsai Wei-Chao Ch | 2012 | Cancer Cell2012，，3： | 2 |
| 9 | Antifungal activity of Artemisia annua endophyte cultures against some phytopathogenic fungi 显示文摘 | | 2001 | Journal of Biotechnology2001，38，： | 1 |
| 10 | MicroRNA miR-326 regulates Th-17 differentiation and is associated with the pathogenesis of multiple sclerosis 显示文摘 | Du CH Liu C Kang JK | 2009 | Nature Immunology2009，10，： | 1 |
| 11 | Activity changes of calmodulin and Ca^2+-ATPase during low temperature-induced anthocyanin accumulation in Alternanthera betzickiana显示文摘 | WANG CH Q ZHANG Y F LIU T | 2005 | Physiologia Plantarum2005，124，： | 1 |
| 12 | Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infeetion: a multieenter, randomized eontrolled trial显示文摘 | Liu CH Liu CJ Lin CL | 2008 | Clin Infect Dis2008，47，10： | 1 |
| 13 | From glycerol to allyl alcohol: iron oxide catalyzed dehydration and consecutive hydrogen transfer显示文摘 | LIU Y Ti]YSi]Z H JIA CH J | 2010 | Chem Commun2010，46，8： | 1 |
| 14 | Rational development of serum-free medium for Chinese hamster ovary cells 显示文摘 | Liu CH Chang TY | 2006 | Proc Biochem2006，41，： | 1 |
| 15 | Anterior approach for postero- medial tibial plateau fractures 显示文摘 | Hsieh CH Huang hT Liu PC | 2010 | Kaohsiung J Med Sci2010，26，3： | 1 |
| 16 | Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase显示文摘 | Kuo YC Su CH Liu CY | 2009 | Int J Cancer2009，124，11： | 1 |
| 17 | Cytokine interactions in mesenchy- real stem cells from cord blood 显示文摘 | Liu CH Hwang SM | 2005 | Cytokine2005，32，6： | 1 |
| 18 | Pegylated interferon - e2a with or without low -dose ribavirin for treatment -naive patients with hepatitis C virus genotype 1 receiving hemodial- ysis: a randomized trial 显示文摘 | LIU CH HUANG CF LIU C J | 2013 | Ann Intern Med2013，159，： | 1 |
| 19 | The expression of LytM is down-regulated by RNAⅢ in Staphylococcus aureus显示文摘 | Mu CH Liu Y Gao YP | 2012 | Journal of Basic Microbiology2012，52，6： | 1 |
| 20 | Changing epidemiology of noso- comial bloodstream intections in llteaching hospitals in Taiwan between 1993 and 2006显示文摘 | Liu CY Liao CH Chen YC | 2010 | Wei Mian Yu Gan Ran Za Zhi2010，43，5： | 1 |
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