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| 1 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 2 | Anisotropic,Wrinkled,and Crack-Bridging Structure for Ultrasensitive,Highly Selective Multidirectional Strain Sensors显示文摘Flexible multidirectional strain sensors are crucial to accurately determining the complex strain states involved in emerging sensing applications.Although considerable efforts have been made to construct anisotropic structures for improved selective sensing capabilities,existing anisotropic sensors suffer from a trade-off between high sensitivity and high stretchability with acceptable linearity.Here,an ultrasensitive,highly selective multidirectional sensor is developed by rational design of functionally different anisotropic layers.The bilayer sensor consists of an aligned carbon nanotube(CNT)array assembled on top of a periodically wrinkled and cracked CNT-graphene oxide film.The transversely aligned CNT layer bridge the underlying longitudinal microcracks to effectively discourage their propagation even when highly stretched,leading to superior sensitivity with a gauge factor of 287.6 across a broad linear working range of up to 100%strain.The wrinkles generated through a pre-straining/releasing routine in the direction transverse to CNT alignment is responsible for exceptional selectivity of 6.3,to the benefit of accurate detection of loading directions by the multidirectional sensor.This work proposes a unique approach to leveraging the inherent merits of two cross-influential anisotropic structures to resolve the trade-off among sensitivity,selectivity,and stretchability,demonstrating promising applications in full-range,multi-axis human motion detection for wearable electronics and smart robotics. | Heng Zhang Dan Liu Jeng-Hun Lee Haomin Chen Eunyoung Kim Xi Shen Qingbin Zheng Jinglei Yang Jang-Kyo Kim | 2021 | Nano-Micro Letters2021，13，8： | 3 |
| 3 | Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles显示文摘Photodynamic therapy(PDT)has been applied in clinical treatment of tumors for a long time.However,insufficient supply of pivotal factors including photosensitizer(PS),light,and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of PDT.Nanoparticles have received an influx of attention as drug carriers,and recent studies have demonstrated their promising potential to overcome the obstacles of PDT in tumor tissue.Physicochemical optimization for passive targeting,ligand modification for active targeting,and stimuli-responsive release achieved efficient delivery of PS to tumor tissue.Various trials using upconversion NPs,two-photon lasers,X-rays,and bioluminescence have provided clues for efficient methods of light delivery to deep tissue.Attempts have been made to overcome unfavorable tumor microenvironments via artificial oxygen generation,Fenton reaction,and combination with other chemical drugs.In this review,we introduce these creative approaches to addressing the hurdles facing PDT in tumors.In particular,the studies that have been validated in animal experiments are preferred in this review over proof-of-concept studies that were only performed in cells. | Donghyun Lee Soonmin Kwon Seok-young Jang Eunyoung Park Yeeun Lee Heebeom Koo | 2022 | Bioactive Materials2022，7，2： | 2 |
| 4 | New strategy for reversal tolerant anode for automotive polymer electrolyte fuel cell显示文摘Since the commercialization of the fuel cell electric vehicles (FCEVs), the polymer electrolyte membrane fuel cell system has been actively improved as a powertrain for ultimate environment-friendly vehicle. During the FCEV operation, various transient conditions such as start-up/shut-down and fuel starvation occur irregularly, which deteriorates the durability of the membrane electrode assembly. In particular, when fuel starvation occurs, the carbon support in the anode is oxidized within few minutes, thus the mitigation of this phenomenon is essential for securing the durability. This short review introduces the concept of reversal tolerant anode (RTA), which is a mitigation method using an oxygen evolution catalyst and reviews some previous reports. In addition, new approach for RTA suggested by authors recently, which is the replacement of Pt anode catalyst by multifunctional IrRu alloy catalyst that simultaneously exhibits the activities for the hydrogen oxidation reaction and the oxygen evolution reaction is introduced. | Chanho Pak Seung Woo Lee Chaekyung Baik Bong Ho Lee Dae Jong You Eunyoung You | 2019 | Chinese Chemical Letters2019，30，6： | 2 |
| 5 | Red meat intake and the risk of endometrial cancer:Metaanalysis of observational studies显示文摘AIM:To evaluate whether red meat intake is related to the risk of endometrial cancer(EC) using meta-analysis.METHODS:We searched Pub Med,EMBASE,and the Cochrane Library up to June 2013,using common keywords related to red meat and EC.Case-control studies and cohort studies comparing the risk of endometrial cancer among categories by the amount of intake were included.Eleven case-control studies and five cohort studies met our criteria.We performed a conventional and a dose-response meta-analysis of case-control studies using the Der Simonian-Laird method for random-effects.For cohort studies we performed a conventional meta-analysis.Publication bias was evaluated using Egger's test.RESULTS:In the meta-analysis of 11 case-control studies including 5419 cases and 12654 controls,higher red meat consumption was associated with an increased risk of EC [summary relative risk(SRR) = 1.43,95%CI:1.15-1.79;I2 = 73.3% comparing extreme intake categories).In a dose-response analysis,for red meat intake of 100 g/d,SRR was 1.84(95%CI:1.64-2.05).In contrast,in the meta-analysis of five prospective studies including a total of 2549 cases among 247746 participants,no significant association between red meat intake and EC risk(SRR = 0.97,95%CI:0.85-1.11;I2 = 4.9% comparing extreme intake categories) was observed.CONCLUSION:Our meta-analysis found a significantlinear association between red meat intake and EC risk based on case-control studies but this was not confirmed in prospective studies. | Woong Ju Na Na Keum Dong Hoon Lee Yun Hwan Kim Seung Cheol Kim Eric L Ding Eunyoung Cho | 2015 | World Journal of Meta-Analysis2015，3，2： | 2 |
| 6 | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase显示文摘Oncogenic H 地岬 G12V 和它的变体被显示了禁止肌肉区别。然而,在肌肉区别的 proto-oncogenic 地岬(c 地岬) 的角色仍然保持不清楚。地岬的活跃 GTP 固定的形式包括 Raf, phosphatidylinositol 3-kinase (PI3K ) , Ral-GDS,和播送下游的信号的另外的分子与多样的受动器为伙伴所知。我们假设那 c 地岬可以由有选择地激活 PI3K 刺激肌肉区别,为肌肉区别的一个重要调停人。在我们的实验,由 farnesyltransferase 禁止者和 H 地岬(地岬 S17N ) 的一种主导的否定形式的 c 地岬的抑制压制了肌肉区别。一致地,由 siRNAs 的 H 地岬, K 地岬,和 N 地岬击倒的个人都堵住了肌肉区别。有趣地,我们发现 c 地岬优先地与 PI3K 而非它的主要有约束力的搭挡 c-Raf 交往,在 myogenic 区别期间,与全部的 c 地岬活动仍然保持未改变。PI3K 和它的下游的 myogenic 小径, Nox2/NF-魏 B /inducible 氮的氧化物 synthase (iNOS ) 小径,被发现被 c 地岬活动的抑制在区别期间压制。而且, PI3K 的一种组成地活跃的形式的表示完全救了区别块并且在 c-Ras-inhibited 房间重新激活 Nox2/NF-魏 B /iNOS 小径。根据我们的结果,我们断定与 oncogenic 地岬相反, proto-oncogenic H 地岬, K 地岬,和 N 地岬直接经由 PI3K 和它的下游的发信号小径涉及肌肉区别的提升。另外, PI3K 小径激活与不同主要激活的 Raf/Mek/Erk 小径的并发的抑制被联系。 | Jisun Lee Kyu Jin Choi Min Jin Lim Feng Hong Tae Gyu Choi Eunyoung Tak Seonmin Lee Young-Joo Kim Sung Goo Chang Jin Man Cho Joohun Ha Sung Soo Kim | 2010 | Cell Research2010，20，8： | 2 |
| 7 | Chitosan-g-mPEG- supported palladium (0) catalyst for Suzuki cross-couplingreaction in water显示文摘 | Sin Eunyoung Yi Song Se Lee Yoon Sik | 2010 | Journal of Molecular Catalysis A: Chemica2010，315，1： | 1 |
| 8 | Paraquat intoxication in Korea显示文摘 | Hwang Kyuyoon Lee Eunyoung Hong saeyong | 2002 | Arch Environ Health2002，57，2： | 1 |
| 9 | Chitosan-supported palladium ( O ) catalyst for microwareprompted Suzuki cross-coupling reaction in water 显示文摘 | YI Songse LEE Dongho SIN Eunyoung | 2007 | Tetrahedron Letters2007，48，： | 1 |
| 10 | Determination of illegally bused sedative-hypnotics in hair samples from drug offenders 显示文摘 | Sooyeun Lee Eunyoung Han Sanghwan In | 2011 | Journal of Analytical Toxicology2011，，35： | 1 |
| 11 | High-throughput detection of spore contamina- tion in food packages and food powders using tiered ap- proach of ATP bioluminescence and real-time PCR显示文摘 | Wannasawat Ratphitagsanti Eunyoung Park Chang Soo Lee | 2012 | LWT Food Science and TechnoLogy2012，46，1： | 1 |
| 12 | Effect of Hypobaric Packaging on Respiration and Quality of Strawberry and Curled Lettuce显示文摘 | Duck Soon An Eunyoung Park Dong Sun Lee | 2009 | Postharvest Biology and Technology2009，52，1： | 1 |
| 13 | Chitosan-supported palladium(O) catalyst for microware-prompted Suzuki cross-coupling reaction in water显示文摘 | Song-Se Yi Dong-Ho Lee Eunyoung Sin | 2007 | Tetrahedron Letters2007，48，： | 1 |
| 14 | Devel-oping a Common Health Information Exchange Platformto Implement a Nationwide Health Information Networkin South Korea 显示文摘 | Minho Lee Eunyoung Heo Heesook Lim | 2015 | Healthc Inform Res2015，21，1： | 1 |
| 15 | Interferon-gamma InhibitsHealing Post Scald Bum Injury显示文摘 | Haitao Shen Pamela Yao Eunyoung Lee | 2012 | Wound Repair Regen2012，20，4： | 1 |
| 16 | Rapid quantitative analysis of oxiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry显示文摘 | Junghyun Son Jaeick Lee Mijin Lee Eunyoung Lee Kyung Tae Lee Sookie La Dong-Hyun Kim | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，，1： | 1 |
| 17 | Source identification of PM 10 pollution in subway passenger cabins using positive matrix factorization显示文摘 | Duckshin Park Miseok Oh Younghun Yoon Eunyoung Park Kiyoung Lee | 2011 | Atmospheric Environment2011，，： | 1 |
| 18 | Dual positional specificity and expression of non-traditional lipoxygenase induced by wounding and methyl jasmonate in maize seedlings显示文摘 | Eun-Seon Kim Eunyoung Choi Youngsun Kim Kyoungwon Cho Ayoung Lee Jaehan Shim Randeep Rakwal Ganesh Kumar Agrawal Oksoo Han | 2003 | Plant Molecular Biology2003，，6： | 1 |
| 19 | Photocatalytic bacterial inactivation by polyoxometalates显示文摘 | Eunyoung Bae Jae Won Lee | 2008 | Chemospere2008，71，1： | 1 |
| 20 | Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials显示文摘Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial resistance.However,the effective minimal antibiotic duration for AOM remains unclear.Moreover,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been assessed.Methods We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October 2021.Network meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 years.For the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day regimens.Compared to amoxicillin,a shorter treatment duration was tolerable with amoxicillin-clavulanate.Conclusions Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 days.Otherwise,5-day regimens would be sufficient for a modest treatment goal.Our findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established. | Min Seo Kim Jae Han Kim Seohyun Ryu Seung Won Lee Dong Keon Yon Eunyoung Kim Ai Koyanagi Elena Dragioti Jae Il Shin Lee Smith | 2024 | World Journal of Pediatrics2024，20，3： | 0 |
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