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| 1 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 2 | Analyzing theEnvironmental Benefits of Industrial Symbiosis: Life CycleAssessment Applied to a Finnish Forest IndustryComplex显示文摘 | Sokka L Lehtoranta S Nissinen A | 2011 | Journal of Industrial Ecology2011，15，15： | 1 |
| 3 | Sediment accumulation of nutrients(N,P) in the eastern Gulf of Finland (Baltic Sea)显示文摘 | Lehtoranta J Pitkaenen H Sandman 0 | 1997 | Water Air Soil Pollule1997，99，14： | 1 |
| 4 | Parallel Implemention of Video Encoder on Quad DSP System 显示文摘 | Olli Lehtoranta | 2002 | Microprocessors and Microsystems2002，26，： | 1 |
| 5 | Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model显示文摘 | Lehtoranta L Vuolteenaho O Laine V J | 2013 | American Journal of Physiology Endocrinology and Metabolism2013，305，5： | 1 |
| 6 | Coastal eutrophication thresholds: a matter of sediment microbial processes显示文摘 | LEHTORANTA J EKHOLM P HEIKKI P | 2009 | AMBIO2009，38，： | 1 |
| 7 | Coastal eutrophication thresholds: A matter of sediment microbial processes 显示文摘 | Lehtoranta J Ekholm P Heikki P | 2009 | AMBIO2009，38，： | 1 |
| 8 | Industrial symbiosis and the policy instruments of sustainable consxnp- tion and production显示文摘 | LEHTORANTA S NISS1NEN A MATTILA T | 2011 | Journal of Cleaner Production2011，19，16： | 1 |
| 9 | Becoming an Acquirer and Becoming Acquired显示文摘 | Lehto E Lehtoranta O | 2004 | Technological Forecasting&Social Change2004，，6： | 1 |
| 10 | Internal nutrient fluxes counteract decreases in external load : the case of the estuarial eastern Gulf of Finland, Baltic Sea 显示文摘 | PITKANEN H LEHTORANTA J RAIKE A | 2001 | AMBIO : A Journal of the Human Environment2001，30，4： | 1 |
| 11 | CYCLOSPORINE A AND PENTOSAN POLYSULFATE SODIUM FOR THE TREATMENT OF INTERSTITIAL CYSTITIS: A RANDOMIZED COMPARATIVE STUDY显示文摘 | JUKKA SAIRANEN TEUVO L.J. TAMMELA MIKAEL LEPPILAHTI MARKKU MULTANEN ILKKA PAANANEN KARI LEHTORANTA MIRJA RUUTU | 2005 | The Journal of Urology2005，，6： | 1 |
| 12 | In-dustrial symbiosis and the policy instruments of sustainableconsumption and production显示文摘 | Suvi Lehtoranta Ari Nissinen Tuomas Mattila | 2011 | Journal of Cleaner Produc-tion2011，19，16： | 1 |
| 13 | Holmium:YAG laser for urinary stones显示文摘 | Taari K Lehtoranta K Rannikko S | 1999 | Scand J Urol Nephrol1999，33，5： | 1 |
| 14 | Industrial symbiosis and the policy instruments of sus- tainable consumption and production 显示文摘 | LEHTORANTA S N1SSINEN A MATTILA T | 2011 | Journal o{ Cleaner Production2011，19，16： | 1 |
| 15 | Coastal eutrophication thresholds: A matter of sediment microbial processes 显示文摘 | Lehtoranta J Ekholm P Heikki P | 2009 | AMBIO2009，38，6： | 1 |
| 16 | Influence of O2 and H2 on NO reduction by NH3 over Ag/Al203:a transient isotopic approach显示文摘 | Evgenii V Kondratenko M Lehtoranta K | | 0，，： | 1 |
| 17 | Does control of soil erosion inhibit aquatic eutrophication显示文摘 | Ekholm P Lehtoranta J | | 0，，01： | 1 |
| 18 | Dissolved iron:phosphate ratio as an indicator of phosphate release to oxic water of the inner and outer coastal Baltic Sea显示文摘 | Jouni Lehtoranta Anna-Stiina Heiskanen | 2003 | Hydrobiologia (-)2003，，1： | 1 |
| 19 | Dissolved iron:phosphate ratio as an indicator of phosphate release to oxic water of the inner and outer coastal Baltic Sea显示文摘 | Jouni Lehtoranta Anna-Stiina Heiskanen | 2003 | Hydrobiologia (-)2003，，1： | 1 |
| 20 | Particulate N and P characterizing the fate of nutrients along the estuarine gradient of the River Neva(Baltic Sea)显示文摘 | LEHTORANTA J HEISKANENB A PITKANEN H | 2004 | Estuarine Coastal and Shelf Science2004，61，2： | 1 |
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