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| 1 | Mechanical Behaviour and Microstructure Evolution of Superplastic Mg-8.4 wt pct Li Alloy and Effect of Grain Size and Phase Ratio on Its Elongation显示文摘Mechanical properties and microstructure evolution of Mg-8.4 wt pct Li alloy have been investi- gated. The superplastic elongation-to-failure 920% at 573 K and initial strain rate of 5 × 10-4 s-1 at low nominal stress 2 MPa has been demonstrated. It was shown through optical microstructure that the average grain sizes at gauge length section before and after superplastic tension and at grip section were 7.5 μm, 31.7 μm and 20 μm respectively, indicating significant deformation induced grain growth and static grain growth. Comparison of experiment data with published data for superplastic Mg-Li alloys shows that fine grain size and about 50 to 50 phase ratio contribute to achieving the largest superplasticity. Some related research works in other alloys are compiled and further evidences to such theoretic argument are provided. | Cao, FR Cui, JZ Wen, JL Lei, F | 2000 | Journal of Materials Science & Technology2000，16，1： | 5 |
| 2 | Effect of physical training on the age-related changes of acetylcholinesterase-positive fibers in the hippocampal formation and parietal cortex in the C57BL/6J mouse显示文摘 | Chen YC Lei JL Chert QS | 1995 | Mech Ageing Dev1995，102，1： | 1 |
| 3 | Structure-function analysis of human glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type la显示文摘 | Lei KJ Pan CJ Liu JL Shelly LL Chou JY | 1995 | J Biol Chem1995，270，11： | 1 |
| 4 | Therapeutic benefit of intravenous administration of bone marrow stromal cells after cere bral ischemia in rats显示文摘 | Chen JL Li Y Lei Wang L | 2001 | Stroke2001，32，： | 1 |
| 5 | Fecal microbiota transplantation (FMT) in multiple sclerosis (MS) 显示文摘 | Borody TJ Leis SM Campbell JL | 2011 | Am J Gastroenterol2011，106，： | 1 |
| 6 | Comer treatment by assigning dual tractions to every node for elastodynamics in TD-BEM显示文摘 | Jl D F LEI W D LI H J | 2016 | Applied Mathematics and Computation2016，284，： | 1 |
| 7 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 8 | Endarterectomy versus angioplasty in patients with symptomatic severe carotid stenosis (eva-3s) trial: results up to 4 years fi-om a randomised, multicentre trial显示文摘 | Mas JL Trinquart L Leys D | 2008 | Lancet Neurol2008，7，10： | 1 |
| 9 | Neuroprotective effects of Abacop- terin E from Abacopteris penangiana against oxidative stress-induced neurotoxicity 显示文摘 | Lei YF Fu W Chen JL | 2011 | J Ethnopharmacol2011，134，2： | 1 |
| 10 | Vascular protective potential of the total flavanol glycosides from Abacopteris penangiana via modula- ting nuclear transcription factor-kB signaling pathway and oxidative stress 显示文摘 | Chen JL Chen XL Lei YF | 2011 | J Ethnopharmacol2011，136，1： | 1 |
| 11 | Physical training modifies the age-related decrease of GAP-43 and synaptophysin in the hippocampal formation in C57BL/6J mouse显示文摘 | Chen YC Chen QS Lei JL Wang SL | 1998 | Brain Res1998，806，2： | 1 |
| 12 | Role of Toll-like receptor 4 in intlam- marion-induced pretenn delivery 显示文摘 | Li LP Kang JL Lei WH | 2010 | Mol Hum Reprod2010，16，4： | 1 |
| 13 | Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain 显示文摘 | Lei ZM Rao CV Kornyei JL | 1993 | Endocrinology1993，132，5： | 1 |
| 14 | Endarterectomy versus stenting in Patients with Symptomic Severe Carotid Stenosis (EVA-3S) trial:results up to 4 years from a randomised, multicentre trial 显示文摘 | Mas JL Trinquart L Leys D | 2008 | Lancet Neurol2008，7，： | 1 |
| 15 | Chemical- and irradiation-inducedmutants of indica rice IR64 for forward and reverse genetics 显示文摘 | Wu JL Wu C Lei C | 2005 | Plant Mol Biol2005，59，： | 1 |
| 16 | Cellular responses to ionizing radiation damage 显示文摘 | Lei L Michael S Randy JL | 2001 | Int J Radiat Oncol Biol Phys2001，49，4： | 1 |
| 17 | The developmental stages of mullet Mugil so-iug Basilewsky 显示文摘 | Lei JL | 1979 | Acta Oceanologia Sinica1979，1，： | 1 |
| 18 | Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis(EVA-3S)trial:results up to 4 years from a randomised,multicentre trial显示文摘 | Mas JL Trinquart L Leys D | | 0，，： | 1 |
| 19 | Cellular responses to ionizing radiation damage 显示文摘 | LEI L MICHAEL S RANDY JL | 2001 | Int J Radiat Oncol Biol Phys2001，，49： | 1 |
| 20 | Vitamain D receptor gene polymorphisms influence susceptibility to type I diabetes mellitus in the Taiwanese population 显示文摘 | Chang TJ Lei HH Yeh Jl | 2000 | Clinical Endocrinology2000，52，5： | 1 |
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