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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 4 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 3 |
| 5 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | 2013 (9882)2013，，9882： | 3 |
| 6 | Fow cytometric quantitation of imunflurence intensity: problems and perspectives显示文摘 | Gratama JW D'hautcort JL Mandy F | 1998 | Cytometry1998，33，： | 1 |
| 7 | The hepatitis B virus core and e antigens elicit different Th cell subsets:antigen structure can affect Th cell phenotype显示文摘 | Milich D R Schodel F Hughes JL | 1997 | J Virol1997，71，3： | 1 |
| 8 | A three-arm study comparing immediate tacrolimus therapy with Antithymocyte globulin induction therapy followed by Tacrolimus or Cyclospoine A in adult Renal transplant recipients显示文摘 | Charpentier B Rostaing L Berthoux F Lang P Civati G Touraine JL Squifflet JP Vialtel P Abramowicz D | 2003 | Transplantation2003，75，6： | 1 |
| 9 | Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF 显示文摘 | Quigley M Pereyra F Nilsson B Porichis F Fonseca C Eichbaum Q Julg B Jcsneck JL Brosnahan K Imam S Russell K Toth I Piechocka-Trocha A Dolfi D Ange- losanto J Crawford A Shin H Kwon DS Zupkosky J Francisco L Freeman GJ Wherry Kaufmann DE Walker BD Ebert B Haining WN | 2010 | Nat Med2010，16，10： | 1 |
| 10 | Diploid Musa acuminata genetic diversity as- sayed with sequence -tagged microsatellite sites 显示文摘 | Grapin A Noyer JL Carreel F Dambier D Baurens FC Lanaud C Lagoda PJ | 1998 | Electrophoresis1998，19，： | 1 |
| 11 | Perspectives on the use of new diagnostic tools in the treatment of chronic lym phocytic leukemia 显示文摘 | Binet JL Caligaris-Cappio F Catovsky D | 2006 | Blood2006，107，3： | 1 |
| 12 | Comer treatment by assigning dual tractions to every node for elastodynamics in TD-BEM显示文摘 | Jl D F LEI W D LI H J | 2016 | Applied Mathematics and Computation2016，284，： | 1 |
| 13 | Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cell:the potential role of transcription factor NF-kappaB显示文摘 | Li D Saldeen T Romeo F Mehta JL | 2000 | Circulation2000，102，16： | 1 |
| 14 | The new IL-1 family member IL-1F8 stimulates productionof inflammatory mediators by synovial fibroblasts and articu-lar chondrocytes显示文摘 | Magne D Palmer G Barton JL Mezin F Talabot-Ayer D Bas S Duffy T Noger M Guerne PA Nicklin MJ GabayC | 2006 | Arthritis Res Ther2006，8，3： | 1 |
| 15 | T-614, a novel immunomodulator, at- tenuates joint inflammation and articular damage in collagen-induced arthritis 显示文摘 | Fang D Liang JL Qiong F | 2008 | Arthritis Resrareh Therapy2008，10，6： | 1 |
| 16 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 1 |
| 17 | A Novel Approach to Supplier Selection Based on Vague Sets Group Decision 显示文摘 | Zhang D F Zhang JL Lai KK | 2009 | Expert Systems with Applications2009，37，6： | 1 |
| 18 | 查看详情显示文摘 | JL Holmes F Davisa S D Collyer | | 0，，09： | 1 |
| 19 | Outcomes following Microvascular Free Tissue Transfer in Reconstructing Skull Base Defects显示文摘 | Llorente JL Lopez F Camporro D | 2014 | J Neurol Surg B Skull Base2014，74，5： | 1 |
| 20 | Physical exercise:evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals显示文摘 | Chaouloff F Laude D Elghozi JL | 1989 | J Neural Transm1989，78，2： | 1 |
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