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| 1 | InlB-mediated Listeria monocytogenes internalization requires a balanced phospholipase D activity maintained through phospho-cofilin显示文摘 | HAN Xuelin YU Rentao JI Lei | 2011 | Molecular Microbiology2011，81，4： | 1 |
| 2 | KH型剪切调控蛋白:星形胶质细胞炎性细胞因子生成检测点显示文摘中枢神经系统(CNS)慢性炎性反应是许多神经退行性疾病和自身免疫性疾病的主要病理特点之一。作为免疫活性细胞,星形胶质细胞(Ast)在CNS炎性反应过程中发挥了重要作用。它可表达许多细胞因子,如肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)等,这些细胞因子可直接或通过募集免疫细胞等途径间接促进炎性反应。检测点的存在可保证这些细胞因子的生成受到严密控制。细胞因子mRNA3’-非翻译区的腺苷酸/尿苷酸富含元件(ARE)由于可调节mRNA稳定性和翻译效率而扮演着主要检测点的角色。KH型剪切调控蛋白(KSRP)是一种RNA结合蛋白,可通过与ARE结合降低mRNA的稳定性。本研究检测了KSRP对Ast细胞因子表达和旁分泌表型的影响。笔者发现了一个包括TNF-α和L-1β在内的炎性介质网络。与同窝出生的对照小鼠相比,KSRP-/-小鼠Ast上述炎性介质的表达在RNA水平增高了2~4倍。而这种KSRP-/-小鼠Ast激活后产生的TNF-α和IL-1β甚至能达到对照组的15倍以上。离体情况下,KSRP-/-Ast条件性培养液有趋化作用且能诱导神经元死亡。令人惊讶的是,笔者发现仅通过特定途径激活Ast后才能观察到部分mRNA半衰期延长。荧光素酶报告系统研究显示KSRP可在转录水平和转录后水平调节细胞因子基因的表达。本研究提示KSRP在促炎介质的调控方面发挥重要作用,因此在CNS炎性和自身免疫性疾病中有广泛意义。 | XUELIN LI WEI-JYE LIN CHING-YI CHEN YING SI XIAOWEN ZHANG LIANG LU ESTHER SUSWAM LEI ZHENG PETER H. KING | 2012 | 神经损伤与功能重建2012，7，6： | 1 |
| 3 | Comparison of chemical vapor deposition diamond-,diamond-like carbon- and TiA1N-coated microdrills in graphite machining显示文摘 | Lei Xuelin Wang Liang Shen Bin Sun Fanghong | 2013 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2013，227，： | 1 |
| 4 | Tribological properties and cutting performance of boron and silicon doped diamond films on Co-cemented tungsten carbide inserts显示文摘 | WANG Liang LEI Xuelin SHEN Bin | 2013 | Diamond and Related Materials2013，33，： | 1 |
| 5 | Development of the Miocene Guangle Carbonate Platform in the South China Sea:Architecture and Controlling Factors显示文摘This study investigates the evolution of the Miocene Guangle carbonate platform(or Triton Horst)of the northwestern South China Sea margin.The platform is located at a junction area surrounded by Yinggehai basin,Qiongdongnan basin and Zhongjiannan basin.Well and regional geophysical data allow the identification of the morphologic and stratigraphic patterns.The Guangle carbonate platform was initiated on a tectonic uplift during the Early Miocene.The early platform was limited at Mesozoic granitic basement,pre-Paleogene sediments localized tectonic uplift and was small extension at the beginning stage.While during the Middle Miocene,the carbonate buildup flourished,and grow a thrived and thick carbonate succession overlining the whole Guangle Uplift.The isolated platforms then united afterward and covered an extensive area of several tens of thousands of square kilometers.However,it terminated in the Late Miocene.What are the control factors on the initiation,growth and demise of the Guangle carbonate platform?The onset of widespread carbonate deposits largely reflected the Early Miocene transgression linked with early post-rift subsidence and the opening of the South China Sea.Stressed carbonate growth conditions on the Guangle carbonate platform probably resulted from increased inorganic nutrient input derived from the adjacent uplifted mainland,possibly enhanced by deteriorated climatic conditions promoting platform drowning.Therefore,tectonics and terrigenous input could be two main controlling factors on the development of the Guangle carbonate platforms and main evolution stages. | YANG Zhen LI Xuelin HUANG Lei WANG Liaoliang WU Shiguo ZHANG Xinyuan | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 6 | Structure and defect dual-engineering of cobalt oxides for lowtemperature Zn-air batteries显示文摘The exploration of bifunctional electrocatalysts with high catalytic activity and long-term durability for low-temperature Zn-air batteries(ZABs)is an ongoing challenge.Here,quintet-shelled hollow spheres,P-doped multi-layer Co_(3)O_(4)(PM-Co_(3)O_(4)),with enriched oxygen vacancies are prepared by thermally induced mass relocation and a simple phosphating process.Various advanced characterizations reveal P anion-induced effects on internal electronic structure and local coordination environment.The finite element method elucidates that the complex multi-layer spherical nanostructure is conducive to the transport and diffusion of OH-and O_(2).Benefiting from its unique structural features and abundant oxygen vacancies,the well-designed PM-Co_(3)O_(4) presents small reversible oxygen overpotential for catalyzing oxygen reduction/evolution reactions.Accordingly,the fabricated low-temperature ZABs based on PM-Co_(3)O_(4) as air-cathode exhibit high power density(20.8 mW·cm^(-2))and long-term stability(over 600 cycles)at the ultra-low temperature of-40℃,outperforming state-of-art Pt/C+IrO_(2)-based ZABs.Furthermore,the dynamic evolution mechanism of cobalt oxide catalysts during ZAB operation is elucidated.This work provides a guideline to design efficient electrocatalysts with regulated electronic configurations and exquisite nano-/microstructures for ZABs under extreme working conditions. | Hang Lei Zhuowen Huangfu Liangjun Chen Xuelin Yang Zilong Wang Wenjie Mai | 2024 | Nano Research2024，17，5： | 0 |
| 7 | Low-temperature epitaxy of transferable high-quality Pd(111)films on hybrid graphene/Cu(111)substrate显示文摘The continuous pursuit of miniaturization in the electronics and optoelectronics industry demands all device components with smaller size and higher performance,in which thin metal film is one heart material as conductive electrodes.However,conventional metal filmns are typically polycrystalline with random domain orientations and various grain boundaries,which greatly degrade their mechanical,thermal and electrical properties.Hence,it is highly demanded to produce single-crystal metal films with epitaxy in an appealing route.Traditional epitaxy on non-metal single-crystal substrates has difficulty in exfoliating away due to the formation of chemical bonds.Newly developed epitaxy on single-crystal graphene enables the easy exfoliation of epilayers but the annealing temperature must be high(typical 500-1,000℃ and out of the tolerant range of integrated circuit technology)due to the relative weak intertacial interactions.Here we demonstrate the facile production of 6-inch transferable high-quality Pd(111)filims on single-crystal hybrid graphene/Cu(111)substrate with CMOS-compatible annealing temperature of 150℃ only.The interfacial interaction between Pd and hybrid graphene/Cu(111)substrate is strong enough to enable the low-temperature epitaxy of Pd(111)films and weak enough to facilitate the easy film release from substrate.The obtained Pd(111)films possess superior properties to polyrystalline ones with-0.25 eV higher work function and almost half sheet resistance.This technique is proved to be applicable to other metals,such as Au and Ag.As the single-crystal graphene/Cu(111)substrates are obtained from industrial Cu foils and accessible in meter scale,our work will promote the massive applications of large-area high-quality metal fims in the development of next-generation electronic and optoelectronic devices. | Zhihong Zhang Xiaozhi Xu Ruixi Qiao Junjiang Liu Yuxia Feng Zhibin Zhang Peizhao Song Muhong Wu Lan Zhu Xuelin Yang Peng Gao Lei Liu Jie Xiong Enge Wang Kaihui Liu | 2019 | Nano Research2019，12，11： | 0 |
| 8 | The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis显示文摘DNA methylation,a conserved epigenetic mark,is critical for tuning temporal and spatial gene expression.The Arabidopsis thaliana DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)initiates active DNA demethylation and is required to prevent DNA hypermethylation at thousands of genomic loci.However,how ROS1 is recruited to specific loci is not well understood.Here,we report the discovery of Arabidopsis AGENET Domain Containing Protein 3(AGDP3)as a cellular factor that is required to prevent gene silencing and DNA hypermethylation.AGDP3 binds to H3K9me2 marks in its target DNA via its AGD12 cassette.Analysis of the crystal structure of the AGD12 cassette of AGDP3 in complex with an H3K9me2 peptide revealed that dimethylated H3 K9 and unmodified H3 K4 are specifically anchored into two different surface pockets.A histidine residue located in the methyllysine binding aromatic cage provides AGDP3 with pH-dependent H3K9me2 binding capacity.Our results uncover a molecular mechanism for the regulation of DNA demethylation by the gene silencing mark H3K9me2. | Xuelin Zhou Mengwei Wei Wenfeng Nie Yue Xi Li Peng Qijie Zheng Kai Tang Viswanathan Satheesh Yuhua Wang Jinyan Luo Xuan Du Rui Liu Zhenlin Yang Honggui La Yingli Zhong Yu Yang Jian-Kang Zhu Jiamu Du Mingguang Lei | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
| 9 | Maximum Correntropy Kalman Filtering for Non-Gaussian Systems With State Saturations and Stochastic Nonlinearities显示文摘This paper tackles the maximum correntropy Kalman filtering problem for discrete time-varying non-Gaussian systems subject to state saturations and stochastic nonlinearities. The stochastic nonlinearities, which take the form of statemultiplicative noises, are introduced in systems to describe the phenomenon of nonlinear disturbances. To resist non-Gaussian noises, we consider a new performance index called maximum correntropy criterion(MCC) which describes the similarity between two stochastic variables. To enhance the “robustness” of the kernel parameter selection on the resultant filtering performance, the Cauchy kernel function is adopted to calculate the corresponding correntropy. The goal of this paper is to design a Kalman-type filter for the underlying systems via maximizing the correntropy between the system state and its estimate. By taking advantage of an upper bound on the one-step prediction error covariance, a modified MCC-based performance index is constructed. Subsequently, with the assistance of a fixed-point theorem, the filter gain is obtained by maximizing the proposed cost function. In addition, a sufficient condition is deduced to ensure the uniqueness of the fixed point. Finally, the validity of the filtering method is tested by simulating a numerical example. | Bo Shen Xuelin Wang Lei Zou | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，5： | 0 |
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