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| 1 | A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity显示文摘Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−1.The studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical devices.Maximizing areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal technologies.Herein,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading electrode.By specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass loading.Additionally,the 3D porous graphene network structure in LHGF ensures excellent electron and ion transport.By systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research devices.Furthermore,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries. | Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang Xu Junfei Liang Huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan | 2022 | Nano-Micro Letters2022，14，3： | 4 |
| 2 | Study on activated carbon prepared from coking fly ash with KOH activation 显示文摘 | Ouyang Shuguang Fu Lele Wang Zhi | 2012 | Advanced Materials Research2012，，： | 1 |
| 3 | Diversification for better classification trees 显示文摘 | FU Z GOLDEN B L LELE S | 2006 | Computers and Operations Research2006，33，11： | 1 |
| 4 | Insulin inhibits leukocyte–endothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion显示文摘 | Jia Li Feng Wu Haifeng Zhang Feng Fu Lele Ji Ling Dong Qiuxia Li Wenchong Liu Yuan Zhang Anlin Lv Haichang Wang Jun Ren Feng Gao | 2009 | Journal of Molecular and Cellular Cardiology2009，，4： | 1 |
| 5 | Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress显示文摘 | JI LELE FU FENG ZHANG LIHUA | 2010 | American Journal of Physiology-Endocrinology and Metabolism2010，298，4： | 1 |
| 6 | Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release显示文摘Osteoarthritis(OA)has been regarded as a lubrication deficiency related joint disease.Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA.Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required.Herein,dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt)(PDA-PSPMA)conjugate coating on hollow silica(h-SiO_(2))nanosphere surfaces to engineer functional nanoparticles(h-SiO_(2)/PDA-PSPMA).The as-prepared h-SiO_(2)/PDA-PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA-PSPMA coating and'rolling'effect of h-SiO_(2)nanospheres.In vitro drug loading-release experiments demonstrate that PDA-PSPMA coating functionalized h-SiO_(2)nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug,diclofenac sodium(DS).Such h-SiO_(2)/PDA-PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication anddrugrelease. | Qiangbing WEI Tian FU Lele LEI Huan LIU Yixin ZHANG Shuanhong MA Feng ZHOU | 2023 | Friction2023，11，3： | 0 |
| 7 | Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation显示文摘Long non-coding(lnc)RNA plays important roles in many cellular processes.The function of the vast majority of lncRNAs remains unknown.Here we identified that lncRNA-1700113A16RIK existed in skeletal muscle stem cells(MuSCs)and was significantly elevated during MuSC differentiation.Knockdown of 1700113A16RIK inhibits the differentiation of muscle stem cells.In contrast,overexpression of 1700113A16RIK promotes the differentiation of muscle stem cells.Further study shows the muscle specific transcription factor Myogenin(MyoG)positively regulates the expression of 1700113A16RIK by binding to the promoter region of 1700113A16RIK.Mechanistically,1700113A16RIK may regulate the expression of myogenic genes by directly binding to 3’UTR of an important myogenic transcription factor MEF2D,which in turn promotes the translation of MEF2D.Taken together,our results defined 1700113A16RIK as a positive regulator of MuSC differentiation and elucidated a mechanism as to how 1700113A16RIK regulated MuSC differentiation. | Xin Fu Sheng Li Minzhi Jia Bo Xu Lele Yang Ruimiao Ma Hong Cheng Wenjun Yang Ping Hu | 2022 | Cell Regeneration2022，11，1： | 0 |
| 8 | Study on Antibacterial Activity of 2-Methyl-3-(methylthio)Pyrazine Against Three Strains of Spoilage Bacteria显示文摘Previous studies have shown that glycine and proline are pharmacophores that display antibacterial activity.In the present study,glycine and proline were derivated to diketopiperazine compounds by chemical synthesis method,and their antibacterial activities were evaluated by three strains of spoilage bacteria,Escherichia coli,Pseudomonas aeruginosa and Shewanella putrefaciens,and the relationship of their antibacterial activities and structures was also investigated.Uv-vis spectrophotometry was used to determine the growth curves of three kinds of active indicator bacteria.Minimum inhibitory concentration(MIC)was determined by micro broth dilution method.The results showed that 2-methyl-3-(methylthio)pyrazine had significant antibacterial activity against three strains of the bacteria,and its MIC was 1.25%.It indicates 2-methyl-3-(methylthio)pyrazine has the potential to be developed as a kind of preservative in future. | Kun LI Guanghe ZHU Danning FU Lele LI | 2024 | Agricultural Biotechnology2024，13，1： | 0 |
| 9 | Dietary ribose supplementation improves flesh quality through purine metabolism in gibel carp(Carassius auratus gibelio)显示文摘Since the aquaculture industry is currently observing a deterioration in the flesh quality of farmed fish,the use of nutrients as additives to improve the flesh quality of farmed fish species is a viable strategy.The aim of this study was to investigate the effect of dietary D-ribose(RI)on the nutritional value,texture and flavour of gibel carp(Carassius auratus gibelio).Four diets were formulated containing exogenous RI at 4 gradient levels:0(Control),0.15%(0.15RI),0.30%(0.30RI)and 0.45%(0.45RI).A total of 240 fish(150±0.31 g)were randomly distributed into 12 fibreglass tanks(150 L per tank).Triplicate tanks were randomly assigned to each diet.The feeding trial was carried out in an indoor recirculating aquaculture system for 60 d.After the feeding trial,the muscle and liver of gibel carp were analysed.The results showed that RI supplementation did not result in any negative impact on the growth performance and 0.30RI supplementation significantly increased the whole-body protein content compared to the control group.The contents of collagen and glycogen in muscle were enhanced by RI supplementation.The alterations in the flesh indicated that RI supplementation improved the texture of the flesh in terms of its water-holding capacity and hardness,therefore improving the taste.Dietary RI facilitated the deposition of amino acids and fatty acids in the muscle that contributed to the meaty taste and nutritional value.Furthermore,a combination of metabolomics and expression of key genes in liver and muscle revealed that 0.30RI activated the purine metabolism pathways by supplementing the substrate for nucleotide synthesis and thereby promoting the deposition of flavour substance in flesh.This study offers a new approach for providing healthy,nutritious and flavourful aquatic products. | Wanjie Cai Lele Fu Cui Liu Linyue He Haokun Liu Dong Han Xiaoming Zhu Yunxia Yang Junyan Jin Shouqi Xie | 2023 | Animal Nutrition2023，，2： | 0 |
| 10 | Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritis in vivo显示文摘Osteoarthritis is a prevalent global joint disease,which is characterized by inflammatory reaction and cartilage degradation.Cyasterone,a sterone derived from the roots of Cyathula officinalis Kuan,exerts protective effect against several inflammationrelated diseases.However,its effect on osteoarthritis remains unclear.The current study was designed to investigate the potential antiosteoarthritis activity of cyasterone.Primary chondrocytes isolated from rats induced by interleukin(IL)-1βand a rat model stimulated by monosodium iodoacetate(MIA)were used for in vitro and in vivo experiments,respectively.The results of in vitro experiments showed that cyasterone apparently counteracted chondrocyte apoptosis,increased the expression of collagen II and aggrecan,and restrained the production of the inflammatory factors inducible nitric oxide synthase(iNOS),cyclooxygenase-2(COX-2),a disintegrin and metalloproteinase with thrombospondin motifs-5(ADAMTS-5),metalloproteinase-3(MMP-3),and metalloproteinase-13(MMP13)induced by IL-1βin chondrocytes.Furthermore,cyasterone ameliorated the inflammation and degenerative progression of osteoarthritis potentially by regulating the nuclear factor kappa B(NF-κB)and mitogen-activated protein kinase(MAPK)pathways.For in vivo experiments,cyasterone significantly alleviated the inflammatory response and cartilage destruction of rats induced by monosodium iodoacetate,where dexamethasone was used as the positive control.Overall,this study laid a theoretical foundation for developing cyasterone as an effective agent for the alleviation of osteoarthritis. | TENG Li SHEN Yue QU Yuhan YANG Longfei YANG Yuting JIAN Xi FAN Shengli ZHANG Lele FU Qiang | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 0 |
| 11 | Identification of Bulbocodin D and C as novel STAT3 inhibitors and their anticancer activities in lung cancer cells显示文摘Cancer stands as one of the predominant causes of mortality globally, necessitating ongoing efforts to develop innovative therapeutics. Historically, natural products have been foundational in the quest for anticancer agents. Bulbocodin D (BD) and Bulbocodin C (BC), two bibenzyls derived from Pleione bulbocodioides (Franch.) Rolfe, have demonstrated notable in vitro anticancer activity. In human lung cancer A549 cells, the IC50s for BD and BC were 11.63 and 11.71 μmol·L^(−1), respectively. BD triggered apoptosis, as evidenced by an upsurge in Annexin V-positive cells and elevated protein expression of cleaved-PARP in cancer cells. Furthermore, BD and BC markedly inhibited the migratory and invasive potentials of A549 cells. The altered genes identified through RNA-sequencing analysis were integrated into the CMap dataset, suggesting BD’s role as a potential signal transducer and activator of transcription 3 (STAT3) inhibitor. SwissDock and MOE analyses further revealed that both BD and BC exhibited a commendable binding affinity with STAT3. Additionally, a surface plasmon resonance assay confirmed the direct binding affinity between these compounds and STAT3. Notably, treatment with either BD or BC led to a significant reduction in p-STAT3 (Tyr 705) protein levels, regardless of interleukin-6 stimulation in A549 cells. In addition, the extracellular signal-regulated kinase (ERK) was activated after BD or BC treatment. An enhancement in cancer cell mortality was observed upon combined treatment of BD and U0126, the MEK1/2 inhibitor. In conclusion, BD and BC emerge as promising novel STAT3 inhibitors with potential implications in cancer therapy. | HE Xinyu FU Jiarui LYU Wenyu HUANG Muyang MO Jianshan CHENG Yaxin XU Yulian ZHENG Lijun ZHANG Xiaolei QI Lu ZHANG Lele ZHENG Ying HUANG Mingqing NI Lin LU Jinjian | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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