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| 1 | The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling显示文摘Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging. | Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou | 2022 | Bone Research2022，10，3： | 5 |
| 2 | A Novel Magnetic Carbon Based Catalyst Synthesized from Reed Straw and Electric Furnace Dust for Biodiesel Production显示文摘In the era of serious greenhouse gas emission and energy shortage,it is necessary to use solid waste to prepare new renewable materials.In this work,the potential application of reed straw and electric furnace dust was explored.Firstly,magnetic carbon carrier(EFD&C)was prepared by high temperature calcination,and then magnetic carbon catalyst(SM@EFD&C)was prepared by activation of sodium methoxide.The catalyst was used to prepare biodiesel by transesterification reaction to test its activity and stability.Reed biochar,EFD&C and SM@EFD&C were detected by Diffraction of X-rays(XRD),Fourier transform infrared(FT-IR),Inductively coupled plasma(ICP),Scanning electron microscope(SEM),Transmission electron microscope(TEM),Brunauer-Emmett-Teller(BET),Vibrating sample magnetometer(VSM),Temperature programmed desorption of CO_(2)(CO_(2)-TPD)and Thermogravimetric analysis(TG-DTG).The results showed that SM@EFD&C catalyst had some characteristics including porous structure,easy adsorption and better magnetism.Under the reaction conditions of 65℃for 2 h with 6 wt%catalyst and methanol/oil molar ratio of 15:1,the biodiesel yields from reed biochar and EFD&C were only 4.88 wt%and 0.03 wt%,respectively,while the yield from SM@EFD&C catalyst reached 93.14 wt%(89.84 wt%after 7 cycles)under the same conditions,which proved that it had good catalytic activity and stability when used in biodiesel production.This study is of great significance of carbon dioxide emission reduction and environmental protection. | Fuping Wang Lele Kang Rui Ji Tianji Liu Qing Yu Di Gao Xiaoman Wang Yitong Wang Jie Yang | 2022 | Journal of Renewable Materials2022，10，8： | 1 |
| 3 | Insulin inhibits leukocyte–endothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion显示文摘 | Jia Li Feng Wu Haifeng Zhang Feng Fu Lele Ji Ling Dong Qiuxia Li Wenchong Liu Yuan Zhang Anlin Lv Haichang Wang Jun Ren Feng Gao | 2009 | Journal of Molecular and Cellular Cardiology2009，，4： | 1 |
| 4 | Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress显示文摘 | JI LELE FU FENG ZHANG LIHUA | 2010 | American Journal of Physiology-Endocrinology and Metabolism2010，298，4： | 1 |
| 5 | Achyranthes bidentata Polypeptides Reduces Oxidative Stress and Exerts Protective Effects against Myocardial Ischemic/Reperfusion Injury in Rats显示文摘 | Ru Tie Lele Ji Ying Nan | 2013 | Int J Mol Sci International Journal of Molecular Sciences2013，14，10： | 1 |
| 6 | Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin‐interacting protein显示文摘 | Hui Su Lele Ji Wenjuan Xing Wei Zhang Heping Zhou Xinhong Qian Xiaoming Wang Feng Gao Xin Sun Haifeng Zhang | 2013 | J. Cell. Mol. Med2013，，1： | 1 |
| 7 | A Detection Method of Bolts on Axlebox Cover Based on Cascade Deep Convolutional Neural Network显示文摘This paper proposes a cascade deep convolutional neural network to address the loosening detection problem of bolts on axlebox covers.Firstly,an SSD network based on ResNet50 and CBAM module by improving bolt image features is proposed for locating bolts on axlebox covers.And then,theA2-PFN is proposed according to the slender features of the marker lines for extracting more accurate marker lines regions of the bolts.Finally,a rectangular approximationmethod is proposed to regularize themarker line regions asaway tocalculate the angle of themarker line and plot all the angle values into an angle table,according to which the criteria of the angle table can determine whether the bolt with the marker line is in danger of loosening.Meanwhile,our improved algorithm is compared with the pre-improved algorithmin the object localization stage.The results show that our proposed method has a significant improvement in both detection accuracy and detection speed,where ourmAP(IoU=0.75)reaches 0.77 and fps reaches 16.6.And in the saliency detection stage,after qualitative comparison and quantitative comparison,our method significantly outperforms other state-of-the-art methods,where our MAE reaches 0.092,F-measure reaches 0.948 and AUC reaches 0.943.Ultimately,according to the angle table,out of 676 bolt samples,a total of 60 bolts are loose,69 bolts are at risk of loosening,and 547 bolts are tightened. | Ji Wang Liming Li Shubin Zheng Shuguang Zhao Xiaodong Chai Lele Peng Weiwei Qi Qianqian Tong | 2023 | Computer Modeling in Engineering & Sciences2023，，3： | 0 |
| 8 | Few-Atom Copper Catalyst for the Electrochemical Reduction of CO to Acetate:Synergetic Catalysis between Neighboring Cu Atoms显示文摘Single-atom catalysts(SACs)are gaining increasing recognition because of their superior catalytic properties for various reactions.However,the performance of SACs is often limited by the lack of neighboring metal centers to cooperate in catalysis.Herein,a synergetic interaction between neighboring Cu atoms of a few-atom catalyst(FAC)on graphdiyne(GDY)is found to greatly enhance the production of acetate in the CO electroreduction reaction relative to Cu SACs.In a 1.0 M KOH electrolyte,this Cu FAC exhibits an acetate Faradaic efficiency of 53.8±1.5%,an ultrahigh relative purity of up to 97 wt%for liquid products,and excellent stability over 23 h continuous electrolysis at–0.8 V versus reversible hydrogen electrode.Theoretical studies suggest that the intersite catalytic communication between two neighboring metal atoms confined in each pore of GDY facilitates the formation of acetic acid through either stepwise hydrogenation of CH_(2)CO^(*)or the direct reaction of H_(2)Owith CH_(2)CO^(*).Our study demonstrates the unprecedented synergetic catalysis of Cu FAC in promoting the selective CO electroreduction toward acetate production. | Weifeng Rong Haiyuan Zou Sha Tan Enyuan Hu Fan Li Chao Tang Hao Dai Shuting Wei Yongfei Ji Lele Duan | 2023 | CCS Chemistry2023，5，5： | 0 |
| 9 | Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms显示文摘Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development.Lappaconitine(LA),a potent analgesic drug extracted from the root of natural Aconitum species,has been clinically used for years because of its effective analgesic and non-addictive properties.However,being limited to ethological experiments,previous studies have mainly investigated the analgesic effect of LA at the behavioral level,and the associated antinociceptive mechanisms are still unclear.In this study,electrocorticogram(ECoG)technology was used to investigate the analgesic effects of two homologous derivatives of LA,Lappaconitine hydrobromide(LAH)and Lappaconitine trifluoroacetate(LAF),on Sprague-Dawley rats subjected to nociceptive laser stimuli,and to further explore their antinociceptive mechanisms.We found that both LAH and LAF were effective in reducing pain,as manifested in the remarkable reduction of nocifensive behaviors and laser-evoked potentials(LEPs)amplitudes(N2 and P2 waves,and gamma-band oscillations),and significantly prolonged latencies of the LEP-N2/P2.These changes in LEPs reflect the similar antinociceptive mechanism of LAF and LAH,i.e.,inhibition of the fast signaling pathways.In addition,there were no changes in the auditory-evoked potential(AEP-N1 component)before and after LAF or LAH treatment,suggesting that neither drug had a central anesthetic effect.Importantly,compared with LAH,LAF was superior in its effects on the magnitudes of gamma-band oscillations and the resting-state spectra,which may be associated with their differences in the octanol/water partition coefficient,degree of dissociation,toxicity,and glycine receptor regulation.Altogether,jointly applying nociceptive laser stimuli and ECoG recordings in rats,we provide solid neural evidence for the analgesic efficacy and antinociceptive mechanisms of derivatives of LA. | Guixiang Teng Fengrui Zhang Zhenjiang Li Chun Zhang Libo Zhang Lele Chen Tao Zhou Lupeng Yue Ji Zhang | 2021 | Neuroscience Bulletin2021，37，11： | 0 |
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