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| 1 | A truth serum for cancer -- microRNAs have major potential as cancer biomarkers显示文摘 | Lena J Chin Frank J Slack | 2008 | Cell Research2008，18，10： | 39 |
| 2 | Senescence-specific Alteration of Hydrogen Peroxide Levels in Arabidopsis thaliana and Oilseed Rape Spring Variety Brassica napus L.cv.Mozart显示文摘In order to analyze the signaling function of hydrogen peroxide (H2O2) production in senescence in more detail, we manipulated intracellular H2O2 levels in Arabidopsis thaliala (L.) Heynh by using the hydrogen-peroxide-sensitive part of the Escherichia coli transcription regulator OxyR, which was directed to the cytoplasm as well as into the peroxisomes. H2O2 levels were lowered and senescence was delayed in both transgenic lines, but OxyR was found to be more effective in the cytoplasm. To transfer this knowledge to crop plants, we analyzed oilseed rape plants Brassica napus L. cv. Mozart for H2O2 and its scavenging enzymes catalase (CAT) and ascorbate peroxidase (APX) during leaf and plant development. H2O2 levels were found to increase during bolting and flowering time, but no increase could be observed in the very late stages of senescence. With increasing H2O2 levels, CAT and APX activities declined, so it is likely that similar mechanisms are used in oilseed rape and Arabidopsis to control H2O2 levels. Under elevated CO2 conditions, oilseed rape senescence was accelerated and coincided with an earlier increase in H2O2 levels, indicating that H2O2 may be one of the signals to inducing senescence in a broader range of Brassicaceae. | Stefan Bieker Lena Riester Mark Stahl Jürgen Franzaring Ulrike Zentgraf | 2012 | Journal of Integrative Plant Biology2012，54，8： | 3 |
| 3 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 4 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 5 | Central nervous system cavernomas in children显示文摘 | Lena G Temier J Paz-Paredes A | 2007 | Neurochirurgie2007，53，232： | 1 |
| 6 | The acute phase response and innate immunity of fish显示文摘 | Christopher J Bayne Lena Gerwick | 2001 | Developmental and Comparative Immunology2001，，8： | 1 |
| 7 | Impact of postoperative radiation therapy on survival in patients with complete resection and stageⅠ,Ⅱ,orⅢa non-small-cell lung cancer treated with adjuvant chemotherapy:the adjuvant Navelbine International Trialist Association(ANITA) Randomized Trial显示文摘 | DOUILLARD J Y ROSELL R DE LENA M | | 0，，03： | 1 |
| 8 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage Ⅰ B-Ⅲ A non-small-cell lung cancer[(Adjuvant Navelbine International Trialist Association AN1TA)]:a randomised controlled trial显示文摘 | Douillard J Y Rosell R De Lena M | | 0，，： | 1 |
| 9 | Astmphsical results with the Comeon Adaptive Optics System 显示文摘 | Lena P J | 1994 | Proc SPIE1994，22，1： | 1 |
| 10 | Outcomes following liver transplantation in intensive care unit patients显示文摘AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient survival.METHODS:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December 2010.RESULTS:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and norepinephrine.Sixteen ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to transplantation.Twenty-five ICU patients (64%) required dialysis preoperatively.At 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU patients.Patient survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU patients.When formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable analysis.These findings were consistent in multivariable analysis.Although not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (RR:4.19,P=0.033).Graft survival and patient survival were not significantly worse for patients on mechanical ventilation (RR:0.91,P=0.88 in graft loss;RR:0.69,P=0.56 in death) or patients on vasopressors (RR:1.06,P=0.93 in graft loss;RR:1.24,P=0.74 in death) immediately prior to LT.Trends toward lower graft survival and patient survival were observed for patients on dialysis immediately before LT,however these findings did not approach statistical significance (RR:1.70,P=0.43 in graft loss;RR:1.46,P=0.58 in death).CONCLUSION:Although ICU patients when compared to non-ICU patients have lower survivals,outcomes are still acceptable.Pre-transplant ventilation,hemodialysis,and vasopressors were not associated with adverse outcomes. | Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen | 2013 | World Journal of Hepatology2013，5，1： | 1 |
| 11 | The Stockholm Congestion-charging Trial 2006: Overview of Effects显示文摘 | Eliasson J Lars Hultkrantz Lena Nerhagen | 2009 | Transport Research A2009，43，3： | 1 |
| 12 | Wound infiltration with postoperative pain and PONV after breast surgery显示文摘 | ANDERS J JONAS K LENA N | 2003 | Journal of Clinical Anesthesia2003，15，： | 1 |
| 13 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Gurgel L V A de Melo J C P de Lena J C | 2009 | Bioresource Technology2009，100，13： | 1 |
| 14 | Preoperative stress conditioning prevents paralysis after experimental aortic surgery:increased heat shock protein content is associated with ischemic tolerance of the spinal cord显示文摘 | Perdrizet GA Lena C J Shapiro DS | 2002 | J Thorac Cardiovasc Surg2002，124，1： | 1 |
| 15 | Effects on ground vegetation of the application of wood ash to a Swedish Scots pine stand显示文摘 | Staffan J Lena G | 2001 | Basic and Applied Ecology2001，2，3： | 1 |
| 16 | Implementation of food safety management systems in the UK显示文摘 | Lena D M Denyse J | 2011 | Food Control2011，22，8： | 1 |
| 17 | Properties and structure of solvent - spun and viscose - type fibers in the swollen state显示文摘 | Lena J Schurz J Wrentschur E | 1993 | Colloid & Polym Sci1993，271，5： | 1 |
| 18 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected Stage Ⅰ B-Ⅲ A non-small-cell lung cancer (Adjuvant Navelbine International Tfialist Association ): a randomized controlled trial显示文摘 | Douillard J Y Rosell R De Lena M | 2006 | Lancet Oncol2006，7，9： | 1 |
| 19 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage ⅠB- Ⅲ A non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association ): a randomised controlled trial显示文摘 | Douillard J Rosell R De Lena M | 2006 | Lancet Oncol2006，7，9： | 1 |
| 20 | Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways显示文摘 | Kerstin Eriksson Peetra Magnusson Johan Dixelius Lena Claesson-Welsh Michael J Cross | 2003 | FEBS Letters2003，，1： | 1 |
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