|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat显示文摘 | Joanna K. Tarlow Alexandra I. F. Blakemore Andrew Lennard Roberto Solari Howard N. Hughes Alexander Steinkasserer Gordon W. Duff | 1993 | Human Genetics1993，，4： | 2 |
| 3 | Restoration of saline land through revegetation显示文摘 | Barrett - Lennard E G | 2002 | Agr Water Manage2002，53，13： | 2 |
| 4 | Rapid on-site identification of hazardous organic compounds at fire scenes using person-portable gas chromatography-mass spectrometry(GC-MS)—part 2:water sampling and analysis显示文摘Building and factory fires pose a great risk to human and environmental health,due to the release of hazardous by-products of combustion.These hazardous compounds can dissipate into the environment through fire water run-off,and the impact can be immediate or chronic.Current laboratory-based methods do not report hazardous compounds released from a fire scene at the time and location of the event.Reporting of results is often delayed due to the complexities and logistics of laboratory-based sampling and analysis.These delays pose a risk to the health and wellbeing of the environment and exposed community.Recent developments in person-portable instrumentation have the potential to provide rapid analysis of samples in the field.A portable gas chromatograph-mass spectrometer(GC-MS)was evaluated for the on-site analysis of water samples for the identification of hazardous organic compounds at fire scenes.The portable GC-MS was capable of detecting and identifying a range of volatile and semi-volatile organic compounds in fire water run-off,and can be used in conjunction with conventional laboratory analysis methods for a comprehensive understanding of hazardous organics released at fire scenes.Deployment of this portable instrumentation provides first responders with a rapid,on-site screening tool to appropriately manage the run-off water from firefighting activities.This ensures that environmental and human health is proactively protected. | Rylee Lam Chris Lennard Graham Kingsland Paul Johnstone Andrew Symons Laura Wythes Jeremy Fewtrell David O’Brien Val Spikmans | 2020 | Forensic Sciences Research2020，5，2： | 2 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Vascular endothelial growth factor receptors in osteoclast differentiation and function显示文摘 | Aldridge S E Lennard T W J Williams | 2005 | J Biological and Biophysical Research Communications2005，335，： | 1 |
| 7 | An anterosuperior approach for proximal humeral fractures显示文摘 | Mark Webb Lennard Funk | | 0，，02： | 1 |
| 8 | Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003 显示文摘 | Lennard L Cartwright CS Wade R | 2015 | Br J Haematol2015，170，4： | 1 |
| 9 | Epithelial-to-mesenchymal transition:what is the impact on breast cancer stem cells and drug resistance显示文摘 | Mallini P Lennard T Kirby J | 2014 | Cancer Treat Rev2014，40，3： | 1 |
| 10 | A further study to investigate the detection and enhancement of latent fingerprints using visible absorption and luminescence chemical imaging显示文摘 | Gemma Payne Brian Reedy Chris Lennard Bruce Comber David Exline Claude Roux | 2004 | Forensic Science International2004，，1： | 1 |
| 11 | Interleukin--lbeta,inter- leukin - 5, interleukin - 6, interleukin - 8, and tumor necrosis factor -alpha in chronic sinusitis:response to systemic corticoste- riods显示文摘 | Lennard CM Mann EA Sun LL | 2013 | Am J Rhinol2013，14，3： | 1 |
| 12 | ttigh-performance liquid chromatographic assay of human red blood cell thiopurine methyltrans-ferase activity 显示文摘 | Lennard L Singleton tfJ | 1994 | J Chromatogr B1994，661，： | 1 |
| 13 | Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene显示文摘 | Lennard A Gorman P Carrier M | 1992 | Cytokine1992，4，： | 1 |
| 14 | High - mobility group protein 1 (Y) : metastasis - associated or metastasis - inducing 显示文摘 | Evans A Lennard TW Davies BR | 2004 | J Surg Oncol2004，88，2： | 1 |
| 15 | An evaluation of multimetal deposition II显示文摘 | Jones N Lennard C Stoilovic M | 2002 | J Forensic Identif2002，53，3： | 1 |
| 16 | Intenstity of vascular endothelial growth factor expression is associated with increased risk of recurrence and decreased disease-free survival in papillary thyroid cancer显示文摘 | Lennard CM Patel A Wilson J | 2001 | Surgery2001，129，5： | 1 |
| 17 | Control of emboli in patients with recurrent transient ischemic attacks using preoperative tanscranial Doppler directed therapy显示文摘 | Lennard NS Vijayasekar C Tiivas C | 2003 | Br J Surg2003，90，2： | 1 |
| 18 | Interleukin-1 beta,interleukin-5,interleukin-6,interleukin-8,and tumor necrosis factor alpha in chronic sinusitis:response to systemic corticosteroids显示文摘 | Lennard CM Mann EA Sun LL | 2000 | Am JRhinol2000，14，： | 1 |
| 19 | Varialion between ob- servers in describing mucosal appearances in proctocolitis 显示文摘 | Baron JH Connell AM Lennard -Jones JE | 1964 | Br Med J1964，1，3： | 1 |
| 20 | lnterleukin-1 beta, interleukin -5, interleukin -6,Interleukin -8,and lumor necros,is factor-alpha in ehronic sinusitis: response to systemic Cortieosteroids显示文摘 | Lennard C M Mann E A Sun L L el al | 2000 | Am J Rhinol2000，14，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员