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| 1 | Corrosion behavior of hypoeutectic Al-Cu alloys in H_2SO_4 and NaCl solutions显示文摘The aim of this work was to evaluate the electrochemical behaviour of hypoeutectic Al-Cu alloys immersed in two different solutions containing sulphate and chloride ions,respectively.The influence of Al2Cu associated to the dendritic arm spacing on the general corrosion resistance of such alloys is analysed.The typical microstruc-tural pattern was examined by using scanning electron microscope.The corrosion tests were performed in both 0.5 M sulphuric acid and 0.5 M NaCl solutions at 25°C by using an electrochemical impedance spectroscopy(EIS)technique and potentio-dynamic polarization curves.Equivalent circuits by using the ZView software,were also used to provide quantitative support for the discussions.It was found that as the Cu content increased(i.e.,increasing the Al2Cu fraction),a higher susceptibility to the corrosion action in the NaCl solution is detected.In contrast,the tests carried out in the H2SO4 solution resulted in similar corrosion rates for the three di?erent hypoeutectic alloys. | Wislei R.Osório Leandro C.Peixoto Leonardo R.Garcia Amauri Garcia | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，4： | 3 |
| 2 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 3 | SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity outcome.Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral replication.We found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.In addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)patients.The rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung tissue.These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host. | Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda | 2022 | Journal of Molecular Cell Biology2022，14，4： | 1 |
| 4 | Microstructure and mechanical properties of Sn–Bi, Sn–Ag and Sn–Zn lead-free solder alloys显示文摘 | Wislei R. Osório Leandro C. Peixoto Leonardo R. Garcia Nathalie Mangelinck-No?l Amauri Garcia | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 5 | Effect of insecticides and fungicides on the interaction between members of the mite families Phytoseiidae Stigmaeidae on citrus 显示文摘 | Mário E S Adahon R Leonardo C C Miguel F D S F | 2001 | Experimental and Applied Acarology2001，25，： | 1 |
| 6 | 流域的可持续管理:国际多个流域的案例研究显示文摘全球淡水资源正在不断受到污染和亏耗,威胁着可持续发展及人类和生态系统的健康。本文通过美国、日本、瑞士和巴西四个不同流域的案例研究,阐述了与淡水资源密切相关的可持续发展中的缺陷,指明了水资源可持续管理的总体方向。由于近几十年来人口的增长和经济的发展,每个流域的水质、流量和生物资源量都在下降。但是对于不同的流域来说,与水有关的这些问题的严重程度和文化观念大不相同,因而形成各自独特的水资源管理政策。在工业化国家,例如美国、瑞士和日本,这类政策允许采用资金密集型和能源密集型技术,使得这些国家在满足其水资源需求的同时还能尽量降低人类健康风险。然而,从可持续发展的观点看,以有限的自然资源为基础制定的这类政策,并非长久之计。对于新兴工业化国家(如巴西)来说,昂贵的水资源管理技术在经济上常常行不通,因而限制了新兴工业化国家和发展中国家对发达国家提供的技术的利用程度。要实现水资源的可持续管理,发达国家、新兴工业化国家和发展中国家都需要经历一个学习的过程。 | Walter Wagner James Gawel Hiroaki Furumai Marcelo Pereira de Souza Denilson Teixeira Leonardo Rios Shinichiro Ohgaki Alexander J.B.Zehnder Harold F.Hemond 刘林群 | 2002 | AMBIO-人类环境杂志2002，31，1： | 1 |
| 7 | Percutaneous endoscopic gastrostomy and jejunostomy:Indications and techniques显示文摘Nutritional support is essential in patients who have a limited capability to maintain their body weight.Therefore,oral feeding is the main approach for such patients.When physiological nutrition is not possible,positioning of a nasogastric,nasojejunal tube,or other percutaneous devices may be feasible alternatives.Creating a percutaneous endoscopic gastrostomy(PEG)is a suitable option to be evaluated for patients that need nutritional support for more than 4 wk.Many diseases require nutritional support by PEG,with neurological,oncological,and catabolic diseases being the most common.PEG can be performed endoscopically by various techniques,radiologically or surgically,with different outcomes and related adverse events(AEs).Moreover,some patients that need a PEG placement are fragile and are unable to express their will or sign a written informed consent.These conditions highlight many ethical problems that become difficult to manage as treatment progresses.The aim of this manuscript is to review all current endoscopic techniques for percutaneous access,their indications,postprocedural follow-up,and AEs. | Alessandro Fugazza Antonio Capogreco Annalisa Cappello Rosangela Nicoletti Leonardo Da Rio Piera Alessia Galtieri Roberta Maselli Silvia Carrara Gaia Pellegatta Marco Spadaccini Edoardo Vespa Matteo Colombo Kareem Khalaf Alessandro Repici Andrea Anderloni | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，5： | 1 |
| 8 | Review on renal recovery after anatrophic nephrolithotomy:Are we really healing our patients?显示文摘The main goals for urinary stone treatment are to preserve renal function, reduce or avoid complications related to calculi, and to render the patient free of calculi as soon as possible. Anatrophic nephrolithotomy(ANL) is a valid and useful alternative for conventional staghorn calculi excision. Although excellent stone free rates can be achieved with ANL there are some drawbacks that may be of concern. Morbidity related to intraoperative and postoperative complications isone of them. Another, great concern is the possibility of reduction on renal function related to the procedure itself. This may be related to nephron injury during nephrotomy and parenchymal closure or to ischemic injury. In this review we assess functional results after anatrophic nephrolithotomy. | Leonardo de Albuquerque dos Santos Abreu Douglas Gregório Camilo-Silva Gustavo Fiedler Gustavo Barboza Corguinha Matheus Miranda Paiva Jo?o Antonio Pereira-Correia Valter José Fernandes Muller | 2015 | World Journal of Nephrology2015，4，1： | 1 |
| 9 | Effects of environmental conditions and space on species turnover for three plant functional groups in Brazilian savannas显示文摘Aims Different plant functional groups display diverging responses to the same environmental gradients.Here,we assess the effects of environmental and spatial predictors on species turnover of three functional groups of Brazilian savannas(Cerrado)plants—trees,palms and lianas—across the transition zone between the Cerrado and Amazon biomes in central Brazil.Methods We used edaphic,climatic and plant composition data from nine one-hectare plots to assess the effects of the environment and space on species turnover using a Redundancy Analysis and Generalized Dissimilarity Modeling(GDM),associated with variance partitioning.Important Findings We recorded 167 tree species,5 palms and 4 liana species.Environmental variation was most important in explaining species turnover,relative to geographic distance,but the best predictors differed between functional groups:geographic distance and silt for lianas;silt for palms;geographic distance,temperature and elevation for trees.Geographic distances alone exerted little influence over species turnover for the three functional groups.The pure environmental variation explained most of the liana and palm turnover,while tree turnover was largely explained by the shared spatial and environmental contribution.The effects of geographic distance upon species turnover leveled off at about 300 km for trees,and 200 km for lianas,whereas they were unimportant for palm species turnover.Our results indicate that environmental factors that determine floristic composition and species turnover differ substantially between plant functional groups in savannas.Therefore,we recommend that studies that aim to investigate the role of environmental conditions in determining plant species turnover should examine plant functional groups separately. | Hélio Menegat Divino Vicente Silvério Henrique A.Mews Guarino R.Colli Ana Clara Abadia Leonardo Maracahipes-Santos Lorrayne A.Gonçalves Jhany Martins Eddie Lenza | 2019 | Journal of Plant Ecology2019，12，6： | 1 |
| 10 | How does Cariniana estrellensis respond to different irradiance levels?显示文摘Based on reports that variables related to photosynthesis(net assimilatory ratio and chloroplast pigments)are more plastic than the morphological and biochemical variables in a climax tropical species,Cariniana estrellensis,under contrasting irradiance,we hypothesised that plasticity of gas exchange variables is higher in relation to growth,biochemical and anatomical variables.Plants that were 14 months old were subjected to200 up to 2000 lmol m^(-2)s^(-1) of photo synthetically active radiation(PAR)for 140 days.Growth increased up to1400 lmol m^(-2)s^(-1)PAR and then decreased at 2000 lmol m^(-2)s^(-1) PAR(full sunlight).This was related to the rate of photosynthesis(A)which showed the same tendency as photosystem Ⅱ performance index(PI_(ABS)).The greater thickness of the secondary xylem at 1400 lmol m^(-2)s^(-1) PAR indicated a higher water conductance capacity.The decrease in specific leaf area,elongation of mesophyll cells,and increase in stomatal density observed at higher irradiances were associated with higher leaf fructose and sucrose concentrations.We concluded that the better growth in partial shade was due to higher photosynthetic capacity.On the other hand,photosynthesis was inhibited equally in full sun and deep shade.The high adjustment capacity of C.estrellensis to wide amplitudes of irradiance was provided by greater plasticity of gas exchange variables in relation to growth,anatomical,and biochemical variables. | Flávia Carolina Santos Portela Bernardo Pretti Becacici Macieira Leonardo Valandro Zanetti Vinícius Novo Gama Diolina Moura Silva Camilla Rozindo Dias Milanez Geraldo Rogério Faustini Cuzzuol | 2019 | Journal of Forestry Research2019，30，1： | 0 |
| 11 | The Impact of Credit Ratings on Financial Performance (ROA) and Value Creation (Tobin’s Q)显示文摘This study employs a bibliometric and systematic approach to examine the impact of credit ratings as a measure of financial performance for companies listed in the S&P 500 index.The study identified a knowledge gap as only two researches were found,one suggesting and another using credit ratings to measure financial performance.Most researches use leverage,profitability,liquidity,and Share Return measures to explain financial performance.The empirical analysis uses the data of 2,398 observations of 240 companies rated by S&P Global Ratings for the period 2009-2013,applying a Generalized Method of Moments(GMM)methodology to estimate the models due to its ability to address potential endogeneity issues.The study considers Return on Assets(ROA)and Tobin’s Q as dependent variables.It incorporates credit ratings(CRWLTA)along with variables such as Total Debt to Total Assets(TDTA),Total Shareholder Return(TSR),EBITDA Interest coverage(EBITDAICOV),Quick Ratio(QR),Altman’s Z-Score(AZS),as well as macroeconomic factors like Gross Domestic Product(GDP)growth,inflation(Consumer Price Index-CPI),and the Federal Reserve Interest Rate(FDRI)as independent variables.The study argues that credit ratings,which incorporate historical data and confidential information about companies’strategies,provide reliable forward-looking creditworthiness assessments to the market.It is supported by specialized rating agencies that employ their methodologies.However,the findings suggested that CRWLTA,had a negative relationship with Q Tobin,although it was not statistically significant,and a negative relationship with ROA that was on the verge of significance. | Nazário Augusto de Oliveira Leonardo Fernando Cruz Basso | 2023 | Chinese Business Review2023，22，2： | 0 |
| 12 | Endoscopic management of benign biliary strictures:Looking for the best stent to place显示文摘Benign biliary strictures(BBS)might occur due to different pancreaticobiliary conditions.The etiology and location of biliary strictures are responsible of a wide array of clinical manifestations.The endoscopic approach endoscopic retrograde cholangiopancreatography represents the first-line treatment for BBS,considering interventional radiology and surgery when endoscopic treatment fails or it is not suitable.The purpose of this review is to provide an overview of possible endoscopic treatments for the optimal management of this subset of patients. | Matteo Colombo Edoardo Forcignanò Leonardo Da Rio Marco Spadaccini Marta Andreozzi Carmelo Marco Giacchetto Silvia Carrara Roberta Maselli Piera Alessia Galtieri Gaia Pellegatta Antonio Capogreco Davide Massimi Kareem Khalaf Cesare Hassan Andrea Anderloni Alessandro Repici Alessandro Fugazza | 2023 | World Journal of Clinical Cases2023，11，31： | 0 |
| 13 | Artificial intelligence and inflammatory bowel disease: Where are we going?显示文摘Inflammatory bowel diseases,namely ulcerative colitis and Crohn’s disease,are chronic and relapsing conditions that pose a growing burden on healthcare systems worldwide.Because of their complex and partly unknown etiology and pathogenesis,the management of ulcerative colitis and Crohn’s disease can prove challenging not only from a clinical point of view but also for resource optimization.Artificial intelligence,an umbrella term that encompasses any cognitive function developed by machines for learning or problem solving,and its subsets machine learning and deep learning are becoming ever more essential tools with a plethora of applications in most medical specialties.In this regard gastroenterology is no exception,and due to the importance of endoscopy and imaging numerous clinical studies have been gradually highlighting the relevant role that artificial intelligence has in inflammatory bowel diseases as well.The aim of this review was to summarize the most recent evidence on the use of artificial intelligence in inflammatory bowel diseases in various contexts such as diagnosis,follow-up,treatment,prognosis,cancer surveillance,data collection,and analysis.Moreover,insights into the potential further developments in this field and their effects on future clinical practice were discussed. | Leonardo Da Rio Marco Spadaccini Tommaso Lorenzo Parigi Roberto Gabbiadini Arianna Dal Buono Anita Busacca Roberta Maselli Alessandro Fugazza Matteo Colombo Silvia Carrara Gianluca Franchellucci Ludovico Alfarone Antonio Facciorusso Cesare Hassan Alessandro Repici Alessandro Armuzzi | 2023 | World Journal of Gastroenterology2023，29，3： | 0 |
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