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| 1 | Submucosal tunnel endoscopy:Peroral endoscopicmyotomy and peroral endoscopic tumor resection显示文摘Peroral endoscopic myotomy(POEM) is an innovative,minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy(LHM), not only for all types of esophageal achalasia [classical(Ⅰ), vigorous(Ⅱ), spastic(Ⅲ), Chicago Classification], but also for advanced sigmoid type achalasia(S1 and S2), failed LHM, or other esophageal motility disorders(diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction(EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection(POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors(submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Roberta Maselli Grace Santi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 7 |
| 2 | Multicenter study on endoscopic ultrasound‐guided expandable biliary metal stent placement: Choice of access route, direction of stent insertion, and drainage route显示文摘 | Vinay Dhir Everson L. A. Artifon Kapil Gupta Juan J. Vila Roberta Maselli Mariana Frazao Amit Maydeo | 2014 | Digestive Endoscopy2014，，3： | 5 |
| 3 | Endocytoscopic visualization of squamous cell islands within Barrett's epithelium显示文摘AIM: To study the endocytoscopic visualization of squamous cell islands within Barrett's epithelium. METHODS: Endocytoscopy (ECS) has been studied in the surveillance of Barrett's esophagus, with controversial results. In initial studies, however, a soft catheter type endocytoscope was used, while only methylene blue dye was used for the staining of Barrett's mucosa. Integrated type endocytoscopes (GIF-Q260 EC, Olympus Corp, Tokyo, Japan) have been recently developed, with the incorporation of a high-power magnifying endocytoscope into a standard endoscope together with narrow-band imaging (NBI). Moreover, double staining with a mixture of 0.05% crystal violet and 0.1% of methylene blue (CM) during ECS enables higher quality images comparable to conventional hematoxylin eosin histopathological images.RESULTS: In vivo endocytoscopic visualization of papillary squamous cell islands within glandular Barrett's epithelium in a patient with long-segment Barrett's esophagus is reported. Conventional white light endoscopy showed typical long-segment Barrett's esophagus, with small squamous cell islands within normal Barrett's mucosa, which were better visualized by NBI endoscopy. ECS after double CM staining showed regular Barrett's esophagus, while higher magnification (×480) revealed the orifices of glandular structures better. Furthermore, typical squamous cell papillary protrusion, classified as endocytoscopic atypia classification (ECA) 2 according to ECA, was identified within regular glandular Barrett's mucosa. Histological examination of biopsies taken from the same area showed squamous epithelium within glandular Barrett's mucosa, corresponding well to endocytoscopic findings. CONCLUSION: To our knowledge, this is the first report of in vivo visualization of esophageal papillary squamous cell islands surrounded by glandular Barrett's epithelium. | Nicholas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Toshihisa Hosoya Roberta Maselli Shin-ei Kudo | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 2 |
| 4 | Per-oral Endoscopic Myotomy is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Re-Do Surgical Heller Myotomy: A Single Center Prospective Study显示文摘 | Manabu Onimaru Haruhiro Inoue Haruo Ikeda Akira Yoshida Esperanza Grace Santi Hiroki Sato Hiroaki Ito Roberta Maselli Shin-ei Kudo | 2013 | Journal of the American College of Surgeons2013，，： | 2 |
| 5 | 54 Clinical Results in 300 Cases of POEM for Esophageal Achalasia a Single Institute Registered Prospective Study显示文摘 | Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Hiroki Sato Esperanza Grace R. Santi Roberta Maselli Nicholas Eleftheriadis Shin-Ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，5： | 2 |
| 6 | Adjustable Intragastric Balloon vs Non-Adjustable Intragastric Balloon: Case–Control Study on Complications, Tolerance, and Efficacy显示文摘 | Alfredo Genco Daniela Dellepiane Giovanni Baglio Fulvio Cappelletti Francesca Frangella Roberta Maselli Maria Chiara Dante Romina Camoirano Michele Lorenzo Nicola Basso | 2013 | Obesity Surgery2013，，7： | 2 |
| 7 | Acetic acid spray enhances accuracy of narrow-band imaging magnifying endoscopy for endoscopic tissue characterization of early gastric cancer显示文摘 | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Roberta Maselli Grace Santi Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 8 | Multi-Centre European Experience with Intragastric Balloon in Overweight Populations: 13 Years of Experience显示文摘 | Alfredo Genco Gontrand López-Nava Christian Wahlen Roberta Maselli Massimiliano Cipriano Maria Mara Arenas Sanchez Chantal Jacobs Michele Lorenzo | 2013 | Obesity Surgery2013，，4： | 2 |
| 9 | Training in peroral endoscopic myotomy (POEM) for esophageal achalasia显示文摘 | Nicholas Eleftheriadis Haruhiro Inoue Shin-ei Kudo Roberta Maselli Toshihisa Hosoya Akira Yoshida Manabu Onimaru Haruo Ikeda | 2012 | Therapeutics and Clinical Risk Management (default)2012，，： | 1 |
| 10 | Multicenter study on endoscopic ultrasound‐guided expandable biliary metal stent placement: Choice of access route, direction of stent insertion, and drainage route显示文摘 | Vinay Dhir Everson L. A. Artifon Kapil Gupta Juan J. Vila Roberta Maselli Mariana Frazao Amit Maydeo | 2014 | Digestive Endoscopy2014，，3： | 1 |
| 11 | Artificial intelligence technologies for the detection of colorectal lesions: The future is now显示文摘Several studies have shown a significant adenoma miss rate up to 35%during screening colonoscopy,especially in patients with diminutive adenomas.The use of artificial intelligence(AI)in colonoscopy has been gaining popularity by helping endoscopists in polyp detection,with the aim to increase their adenoma detection rate(ADR)and polyp detection rate(PDR)in order to reduce the incidence of interval cancers.The efficacy of deep convolutional neural network(DCNN)-based AI system for polyp detection has been trained and tested in ex vivo settings such as colonoscopy still images or videos.Recent trials have evaluated the real-time efficacy of DCNN-based systems showing promising results in term of improved ADR and PDR.In this review we reported data from the preliminary ex vivo experiences and summarized the results of the initial randomized controlled trials. | Simona Attardo Viveksandeep Thoguluva Chandrasekar Marco Spadaccini Roberta Maselli Harsh K Patel Madhav Desai Antonio Capogreco Matteo Badalamenti Piera Alessia Galtieri Gaia Pellegatta Alessandro Fugazza Silvia Carrara Andrea Anderloni Pietro Occhipinti Cesare Hassan Prateek Sharma Alessandro Repici | 2020 | World Journal of Gastroenterology2020，26，37： | 1 |
| 12 | Intragastric Balloon or Diet Alone? A Retrospective Evaluation显示文摘 | Alfredo Genco Stefano Balducci Vincenzo Bacci Alberto Materia Massimiliano Cipriano Giovanni Baglio Maria Cristina Ribaudo Roberta Maselli Michele Lorenzo Nicola Basso | 2008 | Obesity Surgery2008，，8： | 1 |
| 13 | Control of severe strictures after circumferential endoscopic submucosal dissection for esophageal carcinoma: oral steroid therapy with balloon dilation or balloon dilation alone显示文摘 | Hiroki Sato Haruhiro Inoue Yasutoshi Kobayashi Roberta Maselli Esperanza Grace R. Santi Bu’Hussain Hayee Kenta Igarashi Akira Yoshida Haruo Ikeda Manabu Onimaru Yutaka Aoyagi Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，2： | 1 |
| 14 | Advanced imaging and artificial intelligence for Barrett's esophagus:What we should and soon will do显示文摘Barrett’s esophagus(BE)is a well-established risk factor for esophageal adenocarcinoma.It is recommended that patients have regular endoscopic surveillance,with the ultimate goal of detecting early-stage neoplastic lesions before they can progress to invasive carcinoma.Detection of both dysplasia or early adenocarcinoma permits curative endoscopic treatments,and with this aim,thorough endoscopic assessment is crucial and improves outcomes.The burden of missed neoplasia in BE is still far from being negligible,likely due to inappropriate endoscopic surveillance.Over the last two decades,advanced imaging techniques,moving from traditional dye-spray chromoendoscopy to more practical virtual chromoendoscopy technologies,have been introduced with the aim to enhance neoplasia detection in BE.As witnessed in other fields,artificial intelligence(AI)has revolutionized the field of diagnostic endoscopy and is set to cover a pivotal role in BE as well.The aim of this commentary is to comprehensively summarize present evidence,recent research advances,and future perspectives regarding advanced imaging technology and AI in BE;the combination of computer-aided diagnosis to a widespread adoption of advanced imaging technologies is eagerly awaited.It will also provide a useful step-by-step approach for performing high-quality endoscopy in BE,in order to increase the diagnostic yield of endoscopy in clinical practice. | Marco Spadaccini Edoardo Vespa Viveksandeep Thoguluva Chandrasekar Madhav Desai Harsh K Patel Roberta Maselli Alessandro Fugazza Silvia Carrara Andrea Anderloni Gianluca Franchellucci Alessandro De Marco Cesare Hassan Pradeep Bhandari Prateek Sharma Alessandro Repici | 2022 | World Journal of Gastroenterology2022，28，11： | 1 |
| 15 | Percutaneous endoscopic gastrostomy and jejunostomy:Indications and techniques显示文摘Nutritional support is essential in patients who have a limited capability to maintain their body weight.Therefore,oral feeding is the main approach for such patients.When physiological nutrition is not possible,positioning of a nasogastric,nasojejunal tube,or other percutaneous devices may be feasible alternatives.Creating a percutaneous endoscopic gastrostomy(PEG)is a suitable option to be evaluated for patients that need nutritional support for more than 4 wk.Many diseases require nutritional support by PEG,with neurological,oncological,and catabolic diseases being the most common.PEG can be performed endoscopically by various techniques,radiologically or surgically,with different outcomes and related adverse events(AEs).Moreover,some patients that need a PEG placement are fragile and are unable to express their will or sign a written informed consent.These conditions highlight many ethical problems that become difficult to manage as treatment progresses.The aim of this manuscript is to review all current endoscopic techniques for percutaneous access,their indications,postprocedural follow-up,and AEs. | Alessandro Fugazza Antonio Capogreco Annalisa Cappello Rosangela Nicoletti Leonardo Da Rio Piera Alessia Galtieri Roberta Maselli Silvia Carrara Gaia Pellegatta Marco Spadaccini Edoardo Vespa Matteo Colombo Kareem Khalaf Alessandro Repici Andrea Anderloni | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，5： | 1 |
| 16 | Long-term multiple intragastric balloon treatment—a new strategy to treat morbid obese patients refusing surgery: prospective 6-year follow-up study显示文摘 | Genco Alfredo Maselli Roberta Cipriano Massimiliano Lorenzo Michele Basso Nicola Redler Adriano | 2013 | Surgery for Obesity and Related Diseases2013，，： | 1 |
| 17 | Microvasculature of the esophagus and gastroesophageal junction: Lesson learned from submucosal endoscopy显示文摘Advanced therapeutic endoscopy,in particular endoscopic mucosal resection,endoscopic submucosal dissection,per-oral endoscopic myotomy,submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible.Combining these information with advanced diagnostic endoscopy,the esophagus is organized,from the luminal side to outside,into five layers(epithelium,lamina propria with lamina muscularis mucosa,submucosa,muscle layer,adventitia).A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and,at the lower esophageal sphincter(LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; periesophageal veins in adventitia.These structures are particularly important to define endoscopic landmark for the gastro-esophageal junction,helpful in performing submucosal therapeutic endoscopy. | Roberta Maselli Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Esperanza Grace Santi Hiroki Sato Bu'Hussain Hayee Shin-Ei Kudo | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 0 |
| 18 | Endoscopic management of benign biliary strictures:Looking for the best stent to place显示文摘Benign biliary strictures(BBS)might occur due to different pancreaticobiliary conditions.The etiology and location of biliary strictures are responsible of a wide array of clinical manifestations.The endoscopic approach endoscopic retrograde cholangiopancreatography represents the first-line treatment for BBS,considering interventional radiology and surgery when endoscopic treatment fails or it is not suitable.The purpose of this review is to provide an overview of possible endoscopic treatments for the optimal management of this subset of patients. | Matteo Colombo Edoardo Forcignanò Leonardo Da Rio Marco Spadaccini Marta Andreozzi Carmelo Marco Giacchetto Silvia Carrara Roberta Maselli Piera Alessia Galtieri Gaia Pellegatta Antonio Capogreco Davide Massimi Kareem Khalaf Cesare Hassan Andrea Anderloni Alessandro Repici Alessandro Fugazza | 2023 | World Journal of Clinical Cases2023，11，31： | 0 |
| 19 | Role of endoscopic ultrasound in vascular interventions:Where are we now?显示文摘From a mere diagnostic tool to an imperative treatment modality,endoscopic ultrasound(EUS)has evolved and revolutionized safer efficient options for vascular interventions.Currently it is an alternative treatment option in the management of gastrointestinal bleeding,primarily variceal type bleeding.Conventional treatment option prior to EUS incorporation had limited efficiency and high adverse events.The characterization and detail provided by EUS gives a cutting edge towards a holistically successful management choice.Data indicates that EUS-guided combination therapy of coil embolization and glue injection has the higher efficacy for the treatment of varices.Conversely,similar treatment options that exist for esophageal and other ectopic variceal bleeding was also outlined.In conclusion,many studies refer that a combination therapy of coil and glue injection under EUS guidance provides higher technical success with fewer recurrence and adverse events,making its adaptation in the guideline extremely favorable.Endo-hepatology is a novel disciple with a promising future outlook,we reviewed topics regarding portal vein access,pressure gradient measurement,and thrombus biopsy that are crucial interventions as alternative of radiological procedures.The purpose of this review is to provide an update on the latest available evidence in the literature regarding the role of EUS in vascular interventions.We reviewed the role of EUS in variceal bleeding in recent studies,especially gastric varices and novel approaches aimed at the portal vein. | Alessandro Fugazza Kareem Khalaf Matteo Colombo Silvia Carrara Marco Spadaccini Glenn Koleth Edoardo Troncone Roberta Maselli Alessandro Repici Andrea Anderloni | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，6： | 0 |
| 20 | Artificial intelligence and inflammatory bowel disease: Where are we going?显示文摘Inflammatory bowel diseases,namely ulcerative colitis and Crohn’s disease,are chronic and relapsing conditions that pose a growing burden on healthcare systems worldwide.Because of their complex and partly unknown etiology and pathogenesis,the management of ulcerative colitis and Crohn’s disease can prove challenging not only from a clinical point of view but also for resource optimization.Artificial intelligence,an umbrella term that encompasses any cognitive function developed by machines for learning or problem solving,and its subsets machine learning and deep learning are becoming ever more essential tools with a plethora of applications in most medical specialties.In this regard gastroenterology is no exception,and due to the importance of endoscopy and imaging numerous clinical studies have been gradually highlighting the relevant role that artificial intelligence has in inflammatory bowel diseases as well.The aim of this review was to summarize the most recent evidence on the use of artificial intelligence in inflammatory bowel diseases in various contexts such as diagnosis,follow-up,treatment,prognosis,cancer surveillance,data collection,and analysis.Moreover,insights into the potential further developments in this field and their effects on future clinical practice were discussed. | Leonardo Da Rio Marco Spadaccini Tommaso Lorenzo Parigi Roberto Gabbiadini Arianna Dal Buono Anita Busacca Roberta Maselli Alessandro Fugazza Matteo Colombo Silvia Carrara Gianluca Franchellucci Ludovico Alfarone Antonio Facciorusso Cesare Hassan Alessandro Repici Alessandro Armuzzi | 2023 | World Journal of Gastroenterology2023，29，3： | 0 |
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