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| 1 | NADPH Thioredoxin Reductase C Is Involved in Redox Regulation of the Mg-Chelatase I Subunit in Arabidopsis thaliana Chloroplasts显示文摘 | Juan Manuel Pérez-Ruiz Manuel Guinea Leonor Puerto-Galán Francisco Javier Cejudo | 2014 | Molecular Plant2014，7，7： | 6 |
| 2 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 3 | Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats显示文摘 | Leonor Rivera Rocío Morón Antonio Zarzuelo Milagros Galisteo | 2008 | Biochemical Pharmacology2008，，6： | 2 |
| 4 | Fluoxetine response in impulsive–aggressive behavior and serotonin transporter polymorphism in personality disorder显示文摘 | Hernán Silva Patricia Iturra Aldo Solari Juana Villarroel Sonia Jerez Marco Jiménez Felipe Galleguillos Maria Leonor Bustamante | 2010 | Psychiatric Genetics2010，，1： | 1 |
| 5 | Gla-Rich Protein, a New Player in Tissue calcification?显示文摘 | Leonor Cancela M Conc e i c ao N La i z e V | 2012 | Adv Nut r2012，3，： | 1 |
| 6 | Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: A review显示文摘 | José Ramón Vielma Ernesto Bonilla Leonor Chacín-Bonilla Marylú Mora Shirley Medina-Leendertz Yanauri Bravo | 2014 | Acta Tropica2014，，： | 1 |
| 7 | The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted 显示文摘 | Cristina I Anna M Leonor N | 2011 | Autoimmunity2011，37，4： | 1 |
| 8 | In vitrobioactivity of starch thermoplastic/hydroxyapatite composite biomaterials:an in sim study using atomic force microscopy显示文摘 | Leonor I Ito A Onuma K Kanzaki N Reis R | 2003 | Biomaterials2003，24，4： | 1 |
| 9 | Emergence of NDM-1-producing Klebsiella pneumoniae in Guatemala显示文摘 | Fernando Pasteran Ezequiel Albornoz Diego Faccone Sonia Gomez Claudia Valenzuela Melissa Morales Pavela Estrada Laura Valenzuela Jorge Matheu Leonor Guerriero Enrique Arbizú Yeraldine Calderón Pilar Ramon-Pardo Alejandra Corso | 2012 | Journal of Antimicrobial Chemotherapy2012，，7： | 1 |
| 10 | Expression of Streptococcus pneumoniae antigens,PsaA and PspA by Lactobacillus casei显示文摘 | Maria Leonor S Oliveria Vicente Monedero Eliane N Miyaji | 2003 | FEMS Microbiol Lett2003，227，： | 1 |
| 11 | Identification and Selection of Regional Plants withPotential for Phytoremediation in Abandoned Open PitTailing Dams显示文摘The degree of adaptability and phytoremediation potential of the plant species, Zacate Garrapata, Zacate Banderita, Chivatillo, Oregano, Chamizo and Sotol were evaluated on different substrates (S) composed of tailing (JM) and agricultural land (TA) in different proportions in mass: S1 = 100% TA, S2 = 100% JM, S3 = 50% TA and 50 % JM, S4 = 25% JM and 75% TA, S5 = 75% JM and 25% TA. With the combination of species and substrates, 30 treatments were generated. The heavy metals evaluated were Pb, As, Cu. Fe, Cr and Zn, in root, leaf and stem. The results showed significant statistical differences (p < 0.05), with the Sotol and Zacate Garrapata species being the ones with the highest degree of adaptability and accumulation of heavy metals in interaction with S3. These two species can be used in the remediation of open pit tailing dam. | Luis Miguel Rodríguez Vázquez Ana Irán Prieto Valles Ramón Silva Vázquez Héctorávalos Loya EduardoHerrera Peraza Emilio Yanez Terrazas Francisco Rueda Ever Ulysses Torres Carrillo Leonor CortésPalacios Gilberto Sandino Aquino | 2020 | Journal of Environmental Science and Engineering(A)2020，9，2： | 0 |
| 12 | Immunomodulatory therapy for the management of critically ill patients with COVID-19:A narrative review显示文摘BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the ongoing coronavirus disease 2019(COVID-19)pandemic.Understanding the physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies.AIM To describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of hyperinflammation and abnormal immune responses to disease progression together with a complete narrative review of the different immunoadjuvant treatments used so far in COVID-19 and their indication in severe and life-threatening subsets.METHODS A comprehensive literature search was developed.Authors reviewed the selected manuscripts following the PRISMA recommendations for systematic review and meta-analysis documents and selected the most appropriate.Finally,a recommendation of the use of each treatment was established based on the level of evidence of the articles and documents reviewed.This recommendation was made based on the consensus of all the authors.RESULTS A brief rationale on the SARS-CoV-2 pathogenesis,immune response,and inflammation was developed.The usefulness of 10 different families of treatments related to inflammation and immunopathogenesis of COVID-19 was reviewed and discussed.Finally,based on the level of scientific evidence,a recommendation was established for each of them.CONCLUSION Although several promising therapies exist,only the use of corticosteroids and tocilizumab(or sarilumab in absence of this)have demonstrated evidence enough to recommend its use in critically ill patients with COVID-19.Endotypes including both,clinical and biological characteristics can constitute specific targets for better select certain therapies based on an individualized approach to treatment. | David Andaluz-Ojeda Pablo Vidal-Cortes Álvaro Aparisi Sanz Borja Suberviola Lorena Del Río Carbajo Leonor Nogales Martín Estefanía Prol Silva Jorge Nieto del Olmo JoséBarberán Ivan Cusacovich | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
| 13 | Frontal penetrating arrow injury:A case report显示文摘BACKGROUND Penetrating arrow injuries of the head and neck are exceedingly rare in pediatric patients.This pathology has high morbidity and mortality because of the presence of vital organs,the airway,and large vessels.Therefore,the treatment and removal of an arrow is a challenge that requires multidisciplinary management.CASE SUMMARY A 13-year-old boy was brought to the emergency room after an arrow injury to the frontal region.The arrowhead was lodged in the oropharynx.Imaging studies showed a lesion of the paranasal sinuses without compromising vital structures.The arrow was successfully removed by retrograde nasoendoscopy without complications,and the patient was discharged.CONCLUSION Although rare,maxillofacial arrow injuries have high morbidity and mortality and require multidisciplinary management to preserve function and aesthetics. | Alejandra Rodríguez-Ramos Carlos A Zapata-Castilleja José L Treviño-González Gerardo C Palacios-Saucedo Ramón G Sánchez-Cortés Leonor G Hinojosa-Amaya Adriana Nieto-Sanjuanero Manuel de la O-Cavazos | 2023 | World Journal of Clinical Cases2023，11，17： | 0 |
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