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| 1 | Inhibition of intestinal and renal Na + -glucose cotransporter by naringenin显示文摘 | Jian Mei Li Chun Tao Che Clara B.S. Lau Po Sing Leung Christopher H.K. Cheng | 2005 | International Journal of Biochemistry and Cell Biology2005，，5： | 2 |
| 2 | Erastin-induced ferroptosis is a regulator forthe growth and function of humanpancreatic islet-like cell clusters显示文摘Ferroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactiveoxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently proposed forcancer treatment. Meanwhile, ROS generation and apoptosis are inherently consequent to cell apoptosis anddysfunction during islet cell preparation and transplantation. Whether ferroptosis induction is a regulator for cellviability and function in human pancreatic islet-cell clusters (ICCs) derived from pancreatic progenitor cells (PPCs)remains elusive. We thus sought to induce ferroptosis in our established cell culture system of human PPCs/ICCs,examine the effects of ferroptosis on ICCs, and explore the potential regulatory pathways involved. Our resultsshowed that ICCs were prone to the use of ferroptosis-inducing and inhibiting agents under our culture conditions.Erastin, a ferroptosis inducer, was found to trigger ferroptosis in ICCs, without the apparent detection of other typesof cell death involved, such as apoptosis and autophagy. In corroboration, the use of ferroptosis inhibitor,ferrostatin-1 (Fer-1), was found to enhance the cell viability of ICCs and prevent them from ferroptosis as well asimprove its function. Mechanistically, the erastin-induced ferroptosis in ICCs was probably mediated via activation ofJNK/P38/MAPK pathways and upregulation of NOX4 expression. Together, our findings may provide a scientificbasis of ferroptosis inhibition as a potential for the amelioration of ICC survival and functionality during islettransplantation in diabetic patients. | Xing Yu Li Po Sing Leung | 2020 | Cell Regeneration2020，9，1： | 2 |
| 3 | Balloon Dilation With Adequate Duration Is Safer Than Sphincterotomy for Extracting Bile Duct Stones: A Systematic Review and Meta-analyses显示文摘 | Wei–Chih Liao Yu–Kang Tu Ming–Shiang Wu Hsiu–Po Wang Jaw–Town Lin Joseph W. Leung Kuo–Liong Chien | 2012 | Clinical Gastroenterology and Hepatology2012，，10： | 2 |
| 4 | Following the recovery of naso-pharyngeal cancer patients by trace elements in hair using statistical pattern recognition methods显示文摘 | Po Lau Leung Han Ming Huang | 1998 | Biological Trace Element Research1998，，3： | 1 |
| 5 | Tissue renin - angiotensin system: its expression, localization, regulation and potential role in the pancreas显示文摘 | Leung PS Carlsson PO | 2001 | J Mol Endocrinol2001，26，3： | 1 |
| 6 | Evidence for a local angiotensingenerating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin Ⅱ in isolated pancreatic islets显示文摘 | Lau T Carlsson PO Leung PS | 2004 | Diabetologia2004，47，2： | 1 |
| 7 | Multielement analysis in serum of thyroid cancer patients before and after a surgical operation显示文摘 | Po Lau Leung Xiao Liang Li | 1996 | Biological Trace Element Research1996，，3： | 1 |
| 8 | The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2显示文摘 | Leung KM Po LS Tsang FC | 2002 | Cancer Res2002，62，： | 1 |
| 9 | Tissue renin-angiotensin system:its expression,localization,regulation and potential role in the pancreas 显示文摘 | Leung PS Carlsson PO | 2001 | J Mol Endocrinol2001，26，3： | 1 |
| 10 | Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin Ⅱ in isolated pancreatic islets 显示文摘 | Lau T Carlsson PO Leung PS | 2004 | Diabetologia2004，47，2： | 1 |
| 11 | Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas 显示文摘 | Leung PS Carlsson PO | 2001 | J Mol Endocrinol2001，26，3： | 1 |
| 12 | Increased messenger RNA expression of vascular endothelial growth factor and its receptors in the implantation site of the human oviduct with ectopic gestation显示文摘 | Po Mui Lam Christine Briton-Jones Che Kwok Cheung See Wai Leung Lai Ping Cheung Christopher Haines | 2004 | Fertility and Sterility2004，，3： | 1 |
| 13 | The candidate tumor suppressor ING1 b can stabilize p53 by disrupting the regulation of p53 byMDM2显示文摘 | Leung K M Po L S Tsang F C | 2002 | Cancer Res2002，62，17： | 1 |
| 14 | Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus显示文摘 | Leung PS Carlsson PO | 2005 | Pancreas2005，30，4： | 1 |
| 15 | Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin Ⅱ in isolated pancreatic islets显示文摘 | Lau T Carlsson PO Leung PS | 2004 | Diabetologia2004，47，2： | 1 |
| 16 | Different comp- liance of central line insertion bundle between intensivists and nonintensivist staffs in intensive care unit 显示文摘 | Leung PO Lin HL Lin YH | 2014 | Infect Control Hosp Epidemiol2014，35，5： | 1 |
| 17 | The candidate tumor suppressor ING1 can stabilize p53 by disrupting the regulation of p53 by MDM2显示文摘 | Leung KI Po LS Tsang FC | 2002 | Cancer Res2002，62，： | 1 |
| 18 | INGlb Decreases Cell Proliferation Through p53-dependent and Independent Mechanisms显示文摘 | Tsang F C Po L S Leung K M | 2003 | FEBS Lett2003，553，3： | 1 |
| 19 | ING1b decreases cell proliferation through p53 -dependent and - independent mechanisms 显示文摘 | Tsang FC Po LS Leung KM | 2003 | FEBS Lett2003，553，3： | 1 |
| 20 | Chemical properties and antioxidant activity of exopolysaccharides from mycelial culture of Cordyceps sinensisfungus Cs - HK1 显示文摘 | Po Hong Leung Shuna Zhao Kwok Ping Ho | 2009 | Food Chemistry2009，114，4： | 1 |
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