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| 1 | Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells显示文摘 | Zhikun Li Haifeng Wan Guihai Feng Leyun Wang Zhengquan He YukaiWang Xiu-Jie Wang Wei Li Qi Zhou Baoyang Hu | 2016 | Cell Research2016，26，1： | 15 |
| 2 | Investigation of the alloying effect on deformation behavior in Mg by Visco-Plastic Self-Consistent modeling显示文摘Alloying elements can drastically alter the deformation behavior of Mg.In the present work,Visco-Plastic Self-Consistent(VPSC)modeling was employed to investigate the effect of alloying elements on Mg’s tensile behavior,in particular the relative activity of different slip and twinning modes.Mg-0.47 wt.%Ca,Mg-2 wt.%Nd,and AZ31 extruded alloys were deformed by micro-tensile tests in a scanning electron microscope(SEM).Texture and grain size measured by electron backscatter diffraction(EBSD)were used as the input for VPSC.After parameter optimization,the VPSC model successfully reproduced the stress-strain curve of each alloy.Simulation results indicate that the slip/twinning activity in the three alloys are different.Mg-0.47 wt.%Ca shows strong extrusion texture,and prismatic slip was quite active during its tensile deformation.In contrast,Mg-2 wt.%Nd shows weak extrusion texture,and basal slip was dominant.This alloy also developed more twinning activity than the other two alloys.AZ31 shows strong extrusion texture similar as Mg-0.47 wt.%Ca,but prismatic slip was less active in it.The slip/twinning activity revealed by the VPSC model can explain the difference in the tensile behavior of the three alloys. | Alireza Maldar Leyun Wang Gaoming Zhu Xiaoqin Zeng | 2020 | Journal of Magnesium and Alloys2020，8，1： | 5 |
| 3 | Grain-scale deformation in a Mg-0.8wt% Y alloy using crystal plasticity finite element method显示文摘Magnesium(Mg) alloys with hexagonal close-packed(HCP) structure usually have a poor ductility at room temperature. The addition of yttrium(Y) can improve the ductility of Mg alloys. To understand the underlying mechanism, crystal plasticity finite element method(CPFEM) was employed to simulate the tensile deformation of a Mg-0.8 wt% Y alloy. The simulated stress–strain curve and the grain-scale slip activities were compared with an in-situ tensile test conducted in a scanning electron microscope.According to the CPFEM result, basal slip is the dominant deformation mode in the plastic deformation stage, accounting for about 50% of total strain. Prismatic slip and pyramidal a slip are responsible for about 25% and 20% of the total strain, respectively. Pyramidal c + a slip and twinning, on the other hand,accommodate much less strain. | Wenxue Li Leyun Wang Bijin Zhou Chuanlai Liu Xiaoqin Zeng | 2019 | Journal of Materials Science & Technology2019，35，10： | 5 |
| 4 | Basal-plane stacking-fault energies of Mg alloys: A first-principles study of metallic alloying effects显示文摘Generalized stacking-fault energies(GSFEs) of basal-plane stacking faults I1 and I2 in Mg alloys have been studied based on first-principles calculations, where 43 alloying elements were considered. It is found that the most contributing features of alloying elements to GSFEs are bulk modulus, equilibrium volume,binding energy, atomic radius and ionization energy. Both bulk modulus and ionization energy exhibit positive relationships with GSFEs, and the others show opposite relationships. Multiple regressions have been performed to offer a quantitative prediction for basal-plane GSFEs in Mg-X systems. GSFEs, alloying effects of elements and the prediction model established within this work may provide guidelines for new Mg alloys design with better ductility. | Qing Dong Zhe Luo Hong Zhu Leyun Wang Tao Ying Zhaohui Jin Dejiang Li Wenjiang Ding Xiaoqin Zeng | 2018 | Journal of Materials Science & Technology2018，34，10： | 4 |
| 5 | Confined interface engineering of self-supported Cu@N-doped graphene for electrocatalytic CO_(2) reduction with enhanced selectivity towards ethanol显示文摘Electroreduction of greenhouse gas CO_(2) into value-added fuels and chemicals provides a promising pathway to address the issues of energy crisis and environmental change.However,the regulations of the selectivity towards C2 product and the competing hydrogen evolution reaction(HER)are major challenges for CO_(2) reduction reaction(CO_(2)RR).Here,we develop an interface-enhanced strategy by depositing a thin layer of nitrogen-doped graphene(N-G)on a Cu foam surface(Cu-N-G)to selectively promote the ethanol pathway in CO_(2)RR.Compared to the undetectable ethanol selectivity of pure Cu and Cu@graphene(Cu-G),Cu-N-G has boosted the ethanol selectivity to 33.1%in total Faradic efficiency(FE)at−0.8 V vs.reversible hydrogen electrode(RHE).The experimental and density functional theory(DFT)results verify that the interconnected graphene coating can not only serve as the fast charge transport channel but also provide confined nanospace for mass transfer.The N doping can not only trigger the intrinsic interaction between N in N-G and CO_(2) molecule for enriching the local concentration of reactants but also promote the average valence state of Cu for C–C coupling pathways.The confinement effect at the interface of Cu-N-G can not only provide high adsorbed hydrogen(Had)coverage but also stabilize the key*HCCHOH intermediate towards ethanol pathway.The provided interface-enhanced strategy herein is expected to inspire the design of Cubased CO_(2)RR electrocatalysts towards multi-carbon products. | Dejin Zang Xuejiao JGao Leyun Li Yongge Wei Haiqing Wang | 2022 | Nano Research2022，15，10： | 3 |
| 6 | Origins of high ductility exhibited by an extruded magnesium alloy Mg-1.8Zn-0.2Ca:Experiments and crystal plasticity modeling显示文摘Low ductility and strength are major bottlenecks against Mg alloys’wide applications.In this work,we systematically design the composition and fabrication process for a low-alloyed Mg-Zn-Ca alloy,showing that it can be extruded at low temperatures(~250℃)and high speeds(~2 mm/s).After the extrusion,this alloy exhibits a substantially weakened basal texture,relatively small grain size,very high tensile elongation(~30%),and good strength.The origin of the considerably improved ductility was studied using a combination of three-dimensional atom probe tomography(3D-APT),transmission electron microscopy(TEM),electron backscattered diffraction(EBSD)in conjunction with surface slip trace analysis,in-situ synchrotron X-ray diffraction,and elasto-plastic self-consistent(EPSC)modeling.Co-segregation of Zn and Ca atoms at a grain boundary is observed and associated with texture weakening and grain boundary mediated plasticity,both improving the ductility.While basal slip and prismatic slip are identified as the dominant deformation systems in the alloy,the ratio between their slip resistances is substantially reduced relative to pure Mg and most other Mg alloys,significantly contributing to the improved ductility of the alloy.This Mg-Zn-Ca alloy exhibiting excellent mechanical properties and low fabrication cost is a promising candidate for industrial productions. | Jie Wang Gaoming Zhu Leyun Wang Evgenii Vasilev Jun-Sang Park Gang Sha Xiaoqin Zeng Marko Knezevic | 2021 | Journal of Materials Science & Technology2021，，25： | 2 |
| 7 | Clusterphene:A new two-dimensional structure from cluster selfassembly显示文摘Since the advent of graphene in 2004,two-dimensional(2D)materials had ignited the development of fascinating functional materials for almost 20 years.Currently,the main members of 2D materials family are graphene,transition metal dichalcogenides(TMDs,MoS_(2),WS_(2),and others),MXenes(Ti_(3)C_(2),Ta_(4)C_(3),and others),Xenes(B,Si,P,Ge,and Sn),organic materials(COF,covalent organic frameworks),etc.The unique sheet-like morphology(single-or few-atomic-layer thickness)endow 2D materials with unconventional physicochemical properties for promising applications in catalysis,energy storage/conversion,electronics,biomedicine,sensors,etc.Nevertheless,the exploration and preparation of novel twodimensional materials with desired characteristics through highly controlled strategy remains one of the major challenges in this field.In a recent work from Nature Chemistry published on 10 February 2022,Liu et al.reported a new member,clusterphene,in the family of two-dimensional materials. | Jian Zhou Leyun Li Xuejiao J.Gao Haiqing Wang | 2022 | Nano Research2022，15，7： | 1 |
| 8 | Sperm cryopreservation of yellow drum Nibea albiflora : A special emphasis on post-thaw sperm quality显示文摘 | Tongren Dai Enhui Zhao Gang Lu Kai Che Qiutao He Yonglin Lu Qiongshan Fang Hansheng Wang Leyun Zheng Suping Li Changjiang Huang Qiaoxiang Dong | 2012 | Aquaculture2012，，： | 1 |
| 9 | 土地利用方式对黄河漫滩土壤微生物群落结构和多样性的影响显示文摘土壤微生物群落及其多样性是土壤碳和养分循环的重要生物指标。土地利用变化是影响漫滩生态系统土壤微生物群落组成的主要决定因素。然而,土壤微生物群落的结构和多样性如何响应土地利用变化,以及这些变化的主要驱动因素是什么,仍不清楚。本研究在黄河漫滩进行,以检验土地利用变化对土壤微生物群落的影响。选取了4种土地利用类型(灌丛、农田、草地和森林),其中以灌木地为对照,用磷脂脂肪酸测量了土壤微生物组成和多样性。研究结果表明,土地利用变化显著影响了总细菌、真菌和革兰氏阳性/阴性细菌。与灌丛相比,农田的总磷脂脂肪酸和细菌较高,森林的真菌较高。土壤pH值和全磷是微生物组成的最佳预测因子,分别解释了37%和26%的变异性。土壤全氮和硝态氮是影响微生物多样性的主要因素。花生农田的土壤碳含量、土壤碳储量、磷脂脂肪酸总量和微生物多样性最高,表明漫滩具有巨大的碳汇潜力。这些研究结果表明,黄河漫滩的农田对于维持土壤微生物群落和土壤碳固存至关重要。 | Xiongde Dong Leyun Yang Laura Sofie Harbo Xinyu Yan Ji Chen Cancan Zhao Yutong Xiao Hao Liu Shilin Wang Yuan Miao Dong Wang Shijie Han | 2023 | Journal of Plant Ecology2023，16，1： | 0 |
| 10 | Differential temperature responses between Plutella xylostella and its specialist endo-larval parasitoid Diadegma semiclausum—Implications for biological control显示文摘Understanding the thermal dynamics of host-parasitoid interactions is crucial to predicting how biological control of pest insects by parasitoids might be affected by geographic location and climate change.We compared performance traits of Plutella xylostella(Lepidoptera:Plutellidae)and its solitary endo-larval parasitoid Diadegma semiclausum(Hymenoptera:Ichneumonidae),over a wide range of constant rearing temperatures(10-30℃).Parasitoids reared at 30℃ experienced reductions in pupation rate,pupal mass,egg load,and adult life span when compared with those reared at lower temperatures.Our analyses of the fate of parasitoids and their hosts and intergenerational population growth at different rearing temperatures show that D.semiclausum and P.xylostella respond differently to temperature,leading to divergent outcomes under different temperature conditions.Some parasitoid larvae could not complete development at 30℃,the temperature at which the host biomass was least and the metabolic demands of the parasitoid could be high,suggesting that parasitoid development might be constrained by lack of host resources at higher temperatures.We discuss the potential mechanisms of parasitoid susceptibility to elevated temperatures,which likely explain the pronounced seasonal dynamics of D.semiclausum in subtropical regions and its failure to establish in lowland tropical regions,where P.xylostella is a serious pest.Similar interactions in other host-parasitoid associations would constrain the efficacy of parasitoids as biological control agents as global temperatures increase. | Leyun Wang Kayvan Etebari Zihua Zhao Gimme H.Walter Michael J.Furlong | 2022 | Insect Science2022，29，3： | 0 |
| 11 | Increased nitrogen fertilization inhibits the biocontrol activity promoted by the intercropping partner plant显示文摘The examination of the compatibility between agricultural practices and biocontrol activities is crucial for establishing an efficient,eco-friendly,and sustainable pest management program.In this study,we examined the population dynamics of two specialist aphids,the English grain aphid(Sitobion avenae)on potted wheat and the pea aphid(Acyrthosiphon pisum)on potted alfalfa,as well as the biocontrol activity of a generalist predator,the harlequin ladybird beetle(Harmonia axyridis).We investigated their responses to the presence of the intercropping partner plant species(alfalfa and wheat,respectively)through plant volatiles or visual cues at three nitrogen fertilizer levels in a greenhouse.In the absence of the predator,the English grain aphid population growth rate increased significantly with increasing nitrogen levels,whereas the pea aphid population increased significantly more slowly in response to high nitrogen levels.The English grain aphid and pea aphid population dynamics were unaffected by the presence of the intercropping partner.However,the presence of the intercropping partner enhanced the control of both aphid populations by the harlequin ladybird beetle.Increasing nitrogen fertilizer levels decreased the predation rates,which were otherwise increased by the intercropping partner.The beneficial effects of the intercropping partner were eventually non-existent at the highest nitrogen level tested.These results imply that the interaction between the presence of intercropping partner and the nitrogen fertilizer application affects the biocontrol activity of the natural enemies of insect pests.Thus,the compatibility between agricultural intensification and biocontrol strategies in integrated pest management programs need to be investigated. | Leyun Wang Hongying Cui Xinyue Chang Mengmeng Zhu Zihua Zhao | 2021 | Insect Science2021，28，4： | 0 |
| 12 | Generation of rat-mouse chimeras by introducing single cells of rat inner cell masses into mouse blastocysts显示文摘In the field of developmental biology and regenerative medicine,mammalian interspecific chimeras have been proved very useful for investigating early embryonic development and the immune system establishment,and extended to a promising potential for human organ generation(Rossant et al.,1982).In the | TiANDa Li Leyun Wang Xinxin Zhang Liyuan Jiang Yufei Li Junjie Mao Tongtong Cui Wei Li Liu Wang Qi Zhou | 2018 | Journal of Genetics and Genomics2018，45，6： | 0 |
| 13 | Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12i^(Max)显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated gene(Cas) system is continually optimized to achieve the most efficient gene editing effect. The Cas12i^(Max), a Cas12i variant, exhibits powerful DNA editing activity and enriches the gene editing toolbox. However, the application of Cas12i^(Max)in large domestic animals has not yet been reported. To verify the efficiency and feasibility of multiple gene editing in large animals, we generated porcine fibroblasts with simultaneous knockouts of IGF2, ANPEP, CD163,and MSTN via Cas12i^(Max)in one step. Phenotypically stable pigs were created through somatic cell nuclear transfer technology. They exhibited improved growth performance and muscle quality. Furthermore, we simultaneously edited three genes in bovine fibroblasts. A knockout of MSTN and PRNP was created and the amino acid Q-G in CD18 was precisely substituted. Meanwhile, no off-target phenomenon was observed by sum-type analysis or off-target detection. These results verified the effectiveness of Cas12i^(Max)for gene editing in livestock animals and demonstrated the potential application of Cas12i^(Max)in the field of animal trait improvement for agricultural production. | Jilong Ren Tang Hai Yangcan Chen Ke Sun Zhiqiang Han Jing Wang Chongyang Li Qingwei Wang Leyun Wang Huabing Zhu Dawei Yu Wei Li Shanjiang Zhao | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 14 | Interface diffusion of sputtered CoZrNb films on silicon substrate显示文摘The amorphous CoZrNb films were deposited by DC magnetron sputtering. The depth distributions of the elements were analyzed by Rutherford backscattering spectrometry (RBS). The results indicate that when the deposition time is longer than 37 min, the film composition keeps constant along the depth. When the deposition time is longer than 45 min, the Co concentration at the interface of the silicon substrate is higher than the average value in the whole film. When the deposition time is longer than 52 min, the Co atoms diffuse into the substrate during the deposition. According to the Co composition profile in the substrate, which were determined from the RBS spectra, the Co diffusion coefficients in the substrate were calculated using the solution of Fick′s second law corresponding to an infinite source with a constant diffusion coefficient. The calculated diffusion coefficients indicate an interstitial assisted diffusion mechanism. | LI Xiaowei WANG Leyun YANG Jing ZENG Fei PAN Feng | 2006 | Rare Metals2006，25，z2： | 0 |
| 15 | Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution显示文摘Dear Editor,The placenta connecting the fetus to the matermal uterus provides material exchange and an immune-tolerant environment for the embryo in all eutherian mammals(Shao et al.,2022).The representative mouse placenta displays a multilayered structure with distinct characteristics and functions,including the matermal decidua,junctional zone,and labyrinth layer(Marsh and Blelloch,2020).The decidua,which is thought to be derived from the matermal endometrium(and further undergoes decidualization),provides an anchor for fetal trophoblast invasion.The junctional zone predominantly contains spongiotrophoblasts(SpT),glycogen trophoblasts(GlyT),and trophoblast giant cells(TGCs).The labyrinth is the innermost two-layer structure,which mainly consists of syncytiotrophoblast cells(SynTI and SynTII),sinusoidal TGCs(S-TGCs),and fetal endothelial cells(Simmons and Cross,2005). | Liyuan Jiang Xin Wang Leyun Wang Sinan Ma Yali Ding Chao Liu Siqi Wang Xuan Sha Ying Zhang Zhikun Li Wei Li Guihai Feng Qi Zhou | 2023 | Protein & Cell2023，14，12： | 0 |
| 16 | Overexpression of Stella improves the efficiency of nuclear transfer reprogramming显示文摘In mammalians,the state of a somatic cell can be reversed from the terminal state to the totipotent state by means of somatic cell nuclear transfer(SCNT)(Gurdon,1962)or induced pluripotent stem cells(iPSCs)(Takahashi and Yamanaka,2006).The DNA methylation and transcriptome profiles of embryonic stem cells(ESCs)derived from SCNT embryos(NT-ESCs)correspond | Leyun Wang Fei Teng Xuewei Yuan Chao Liu qiang Wang Yufei Li Tongtong Cui Tianda Li Zhonghua Liu Qi Zhou | 2017 | Journal of Genetics and Genomics2017，44，7： | 0 |
| 17 | Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging显示文摘Epigenetic alterations and metabolic dysfunction are two hallmarks of aging.However,the mechanism of how their interaction regulates aging,particularly in mammals,remains largely unknown.Here we show ELOVL fatty acid elongase 2(Elovl2),a gene whose epigenetic alterations are most highly correlated with age prediction,contributes to aging by regulating lipid metabolism.We applied artificial intelligence to predict the protein structure of ELOVL2 and the interaction with its substrate.Impaired Elovl2 function disturbs lipid synthesis with increased endoplasmic reticulum stress and mitochondrial dysfunction,leading to key aging phenotypes at both cellular and physiological level.Furthermore,restoration of mitochondrial activity can rescue age-related macular degeneration(AMD)phenotypes induced by Elovl2 deficiency in human retinal pigmental epithelial(RPE)cells;this indicates a conservative mechanism in both human and mouse.Taken together,we revealed an epigenetic-metabolism axis contributing to aging and illustrate the power of an AI-based approach in structure-function studies. | Xin Li Jiaqiang Wang LeYun Wang Yuanxu Gao Guihai Feng Gen Li Jun Zou Meixin Yu Yu Fei Li Chao Liu Xue Wei Yuan Ling Zhao Hong Ouyang Jian-Kang Zhu Wei Li Qi Zhou Kang Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
| 18 | A highly degradable Mg-Al-Ca alloy with superior anti-tumor efficacy显示文摘Molecule hydrogen(H_(2)) has been used to suppress tumor growth. To employ the H_(2) therapy, it is necessary to use a proper agent for continuous generation of H_(2). As a biodegradable metal, magnesium(Mg) generates H_(2) in an aqueous environment, but the H_(2) release rate is still too low. Here, we design a Mg-Al-Ca(AX) alloy that degrades very rapidly due to the presence of a secondary phase Al_(2)Ca. Having a reduction potential much higher than Mg and any other Mg-based secondary phases, Al_(2)Ca accelerates the corrosion of the Mg matrix by a micro-galvanic process. Al_(2)Ca also enhances the strength and ductility of the AX alloy. AX alloy rods show better anti-tumor efficacy than pure Mg rods in vivo. Moreover, implanted AX alloy rods can be heated under an alternating magnetic field to suppress large-size tumors.This work suggests that the H_(2) therapy using highly degradable Mg alloys may provide an effective cancer treatment. | Qiwen Chen Yunhao Fan Shu Dong Ping Han Tian Xie Chenchen Wang Xiaoqin Zeng Wenjiang Ding Zhiqiang Meng Leyun Wang | 2023 | Journal of Magnesium and Alloys2023，11，11： | 0 |
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