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| 1 | Experimental study of an aircraft fuel tank inerting system显示文摘In this work, a simulated aircraft fuel tank inerting system has been successfully established based on a model tank. Experiments were conducted to investigate the influences of different operating parameters on the inerting effectiveness of the system, including flow rate of the inert gas(nitrogen-enriched air), inert gas concentration, fuel load of the tank and different inerting approaches. The experimental results show that under the same operating conditions, the time span of a complete inerting process decreased as the flow rate of inert gas was increased; the time span using the inert gas with 5% oxygen concentration was much longer than that using pure nitrogen;when the fuel tank was inerted using the ullage washing approach, the time span increased as the fuel load was decreased; the ullage washing approach showed the best inerting performance when the time span of a complete inerting process was the evaluation criterion, but when the decrease of dissolved oxygen concentration in the fuel was also considered to characterize the inerting effectiveness, the approach of ullage washing and fuel scrubbing at the same time was the most effective. | Cai Yan Bu Xueqin Lin Guiping Sun Bing Zeng Yu Li Zixuan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 15 |
| 2 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 3 | Research on Glutamate Synthase Activity in Sugar Beet(Beta Vulgaris L.)under Different Levels of Nitrogen显示文摘ResearchonGlutamateSynthaseActivityinSugarBeet(BetaVulgarisL.)underDifferentLevelsofNitrogenYanGuiping,MaFengming,LiWenhuaand... | Yan Guiping, Ma Fengming, Li Wenhua and Gao Jiguo (Northeast Agricultural University, Harbin 150030 PRC) | 1998 | Journal of Northeast Agricultural University(English Edition)1998，5，1： | 7 |
| 4 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | Preparation of multi-color quantum dots and its application to immunohistochemical analysis显示文摘Quantum dots (QDs) have the potential to be used in the multiplexed bioanalysis for their unique property:multi-color QDs can be excited at the same single wavelength light. In this work,high quan-tum yield multi-color core/shell QDs were prepared. After being water-solubilized by amphiphilic polymer based on self-assembling,the QDs would be labeled by two different IgGs and used in the multiplexed biodetection. Fluorescence resonance energy transfer (FRET) should be avoided in the multiplexed biodetection. In this work,spectral analysis showed that no FRET appeared in water-soluble QDs modified by amphiphilic polymer. The immunofluorescence in vitro indicated that the QDs-IgGs bioconjugates had excellent species-specific detection ability with nearly non-specific binding. The setting of this model will help to support the application of multi-color QDs in the multiplexed bioanalysis communities. | ZHANG BingBo LIU XuHui LI DeNa TIAN Hui MA GuiPing CHANG Jin | 2008 | Chinese Science Bulletin2008，53，13： | 6 |
| 6 | Application of Constructed Wetlands on Wastewater Treatment for Aquaculture Ponds显示文摘A group of constructed wetlands (CWs) were applied to the recir-culating aquaculture system. This study assessed the performance of CWs in treating the aquaculture wastewater, examined the water quality condition of aquaculture ponds and the growth and the survival rate of 'target' species (Ictalurus punctatus and Megalobrama amblycephala). The results showed that CWs were effective on reducing the concentrations of 5-day biochemical oxygen demand (BOD5, at 70.5%), total suspended solids (TSS, at 81.9%), chlorophyll a (Chl-a, at 91.9%), ammonium (NH4+, at 61.5%) and nitrate nitro-gen (NO3--N, at 68.0%). Effect of CWs on phosphate (PO43--P) removal was relatively lower (at 20.0%). The concentrations of BOD5, TSS, Chl-a, NH4+ and TN, TP in the recirculating culture pond were significantly lower than that in the control pond( p0.05∧). CWs could help to increase total yield, survival rate of the 'target' species and significantly decrease feed conversion ratio ( p0.05∧). | LI Gu WU Zhenbin CHENG Shuiping LIANG Wei HE Feng FU Guiping ZHONG Fei | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 5 |
| 7 | New insights into the associations among feed efficiency, metabolizable efficiency traits and related QTL regions in broiler chickens显示文摘Background: Improving the feed efficiency would increase profitability for producers while also reducing the environmental footprint of livestock production. This study was conducted to investigate the relationships among feed efficiency traits and metabolizable efficiency traits in 180 male broilers. Significant loci and genes affecting the metabolizable efficiency traits were explored with an imputation-based genome-wide association study. The traits measured or calculated comprised three growth traits, five feed efficiency related traits, and nine metabolizable efficiency traits.Results: The residual feed intake(RFI) showed moderate to high and positive phenotypic correlations with eight other traits measured, including average daily feed intake(ADFI), dry excreta weight(DEW), gross energy excretion(GEE), crude protein excretion(CPE), metabolizable dry matter(MDM), nitrogen corrected apparent metabolizable energy(AMEn), abdominal fat weight(Ab F), and percentage of abdominal fat(Ab P). Greater correlations were observed between growth traits and the feed conversion ratio(FCR) than RFI. In addition, the RFI, FCR, ADFI, DEW,GEE, CPE, MDM, AMEn, Ab F, and Ab P were lower in low-RFI birds than high-RFI birds(P < 0.01 or P < 0.05), whereas the coefficients of MDM and MCP of low-RFI birds were greater than those of high-RFI birds(P < 0.01). Five narrow QTLs for metabolizable efficiency traits were detected, including one 82.46-kb region for DEW and GEE on Gallus gallus chromosome(GGA) 26, one 120.13-kb region for MDM and AMEn on GGA1, one 691.25-kb region for the coefficients of MDM and AMEn on GGA5, one region for the coefficients of MDM and MCP on GGA2(103.45–103.53 Mb), and one 690.50-kb region for the coefficient of MCP on GGA14. Linkage disequilibrium(LD) analysis indicated that the five regions contained high LD blocks, as well as the genes chromosome 26 C6 orf106 homolog(C26 H6 orf106), LOC396098, SH3 and multiple ankyrin repeat domains 2(SHANK2), ETS homologous factor(EHF), and histamine receptor H3-like(HRH3 L), which are known to be involved in the regulation of neurodevelopment, cell proliferation and differentiation, and food intake.Conclusions: Selection for low RFI significantly decreased chicken feed intake, excreta output, and abdominal fat deposition, and increased nutrient digestibility without changing the weight gain. Five novel QTL regions involved in the control of metabolizable efficiency in chickens were identified. These results, combined through nutritional and genetic approaches, should facilitate novel insights into improving feed efficiency in poultry and other species. | Wei Li Ranran Liu Maiqing Zheng Furong Feng Dawei Liu Yuming Guo Guiping Zhao Jie Wen | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 4 |
| 8 | Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice显示文摘Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol(0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice. | Ji Zhang Chunlin Yan Shu Wang Yong Hou Guiping Xue Li Zhang | 2014 | Neural Regeneration Research2014，9，9： | 4 |
| 9 | Low strain rate compressive behavior of high porosity closed-cell aluminum foams显示文摘The impact of a rigid body(protected structure) together with cushion material(cellular metal foam) on hard ground from a fixed height was investigated.An analytical one-degree-of-freedom colliding model(ODF-CM) was established to analyze the protection ability and energy absorption by the foam under low velocity impact conditions.For validation,drop hammer experiments were carried out for high porosity closed-cell aluminum foam specimens subjected to low velocity impact loading.The dynamic deformation behavior of the specimen was observed and the velocity attenuation of the drop hammer was measured.The results demonstrated that the aluminum foam had excellent energy absorption capabilities,with its dynamic compressive behavior similar to that obtained under quasi-static loading conditions.Finite element method(FEM) was subsequently employed to obtain stress distributions in the foam specimen.As the propagating period of stress in the specimen was far less than the duration of attenuation,the evolution of the stress was similar to that under quasi-static loading conditions and no obvious stress wave effect was observed,which agreed with the experimental observation.Finally,the predicted velocity attenuation by the ODF-CM was compared with both the experimental measurements and FEM simulation,and good agreements were achieved when the stress distribution was considered to be uniform and the 'quasi-static' compressive properties are employed. | LI BinChao ZHAO GuiPing LU TianJian | 2012 | Science China(Technological Sciences)2012，55，2： | 3 |
| 10 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 11 | Internal carotid artery agenesis with stenosed intercavernous anastomosis:a case report显示文摘We report a rare case of internal carotid artery agenesis with stenosed intercavernous anastomosis.A 59-yearold male patient presented with a new infarction in the left basal ganglia.Magnetic resonance angiography and cerebral angiography showed that the right internal carotid artery disappeared from the origin to the foramen lacerum segment,and there was an anastomotic artery with severe stenosis passed through the floor of the sella and in front of the cavernous sinus.The right A1 segment of the anterior cerebral artery was absent and A2 segment was supplied by the normal contralateral internal carotid artery via the anterior communicating artery. | Hongzhou Duan Liang Li Guiping Zhao Yang Zhang Jiayong Zhang | 2016 | The Journal of Biomedical Research2016，30，4： | 3 |
| 12 | Duck Solutions: A New Kind of Bifurcation Phenomenon in Relaxation Oscillations | Li Guiping Department of Applied Mathematics Beijing University of Aeronaustics and Astronaustics Beijing, 1000083 China | 1996 | Acta Mathematica Sinica,English Series1996，12，1： | 2 |
| 13 | Electrospun Core-Shell Fibrous 2D Scaffold with Biocompatible Poly(Glycerol Sebacate) and Poly-l-Lactic Acid for Wound Healing显示文摘Biomimetic scaffolds made by synthetic materials are usually used to replace the natural tissues aimed at speeding up the skin regeneration.In this study,a flexible and cytocompatible poly(glycerol sebacate)@poly-l-lactic acid(PGS@PLLA)fibrous scaffold with a core-shell structure was fabricated by coaxial electrospinning,where the shell PLLA was used to be a skeleton with pores on the fibrous surface.The fibrous morphology with pores on the surface of the prepared fibers was observed by SEM.The core-shell microstructure of PGS@PLLA fibers was confirmed by TEM and Laser Scanning Confocal Microscopy(LSCM).In addition,the prepared fibers exhibited a strong ability to repair tissues of the skin wound,where the stability of cell security and proliferation,and the lower inflammatory response were all superior to those of pure PLLA scaffold.It’s worth noting that the percentage of skin tissue was regenerated by 95%within 14 days,which suggests the potential application for electrospun-based synthetic fibrous scaffolds on wound healing. | Xiaoping Yang Lingfeng Li Dongzhi Yang Jun Nie Guiping Ma | 2020 | Advanced Fiber Materials2020，2，2： | 2 |
| 14 | Evolution of Neolithic site distribution(9.0–4.0 ka BP) in Anhui,East China显示文摘Based on archaeological surveys of Neolithic cultural development and GIS spatial analysis,this study reproduced the main characteristics of temporal distribution and settlement selection of the sites from the Neolithic Age in Anhui and identified a relationship between environmental evolution and human activity.The results show that altitude,slope direction,and slope gradient were consistent among the settlements at different stages of the Neolithic Age in Anhui,and the sites were mostly distributed in hilly and plain areas on southeast-or south-facing slopes of low gradients close to rivers.We determined that early Neolithic Age(9.0–7.0 ka BP) sites were scattered in small numbers and likely had little cultural exchange with communities of other provinces.The environmental characteristics of various regions in Anhui indicated that the climate was warm and humid with extensive water distribution.The sites of the mid Neolithic Age(7.0–5.0 ka BP) increased rapidly with wide distribution.They were mainly distributed in the plain area north of the Huaihe River and the southwestern areas of Anhui.In the mid Neolithic Age,the warm and humid climate gradually dried,and our ancestors slowly developed cultural exchanges.The largest number of sites existed during the late Neolithic Age(5.0–4.0 ka BP),and were distributed throughout the province.During this period,the overall climate was relatively dry,but humans could still obtain water and other resources through migration.The relatively benign climate facilitated cultural interaction and exchange,which increased during this time,and the Wanjiang culture matured.We also determined that as early civilization evolved,cultures in different regions responded differently to environmental changes.In humid subtropical regions,especially in low-lying plains and areas beside lakes,rivers,and coastal areas,the relatively dry climate in the late period of the middle Holocene,prefaced by a period of high humidity,was conducive to the development of human culture.The evidence from the Neolithic settlements in Anhui therefore reflects this subtropical man-land relationship between cultural development and environmental conditions. | WU Li SUN Xiaoling SUN Wei ZHU Cheng ZHU Tongxin LU Shuguang ZHOU Hui GUO Qingchun GUAN Houchun XIE Wei KE Rui LIN Guiping | 2020 | Journal of Geographical Sciences2020，30，9： | 2 |
| 15 | List scheduling with duplication for heterogeneous computing systems显示文摘 | Tang Xiaoyong Li Kenli Liao Guiping | 2010 | J Parallel Distrib Comput2010，70，4： | 1 |
| 16 | Load-Balancing and QoS Based Dynamic Resource Allocation Method for Smart Gird Fiber-Wireless Networks显示文摘Real-time network resource allocation based on virtualization technology is an important method to solve the solidification problem of Fiber-wireless(Fi-Wi)access networks.To increase the resource utilization and meet the specific QoS requirements of smart gird communication services,a Load-balancing and QoS based dynamic resource allocation method(LbQ-DR)is proposed with three sub-mechanisms.A time-window based substrate network resource update mechanism is designed to describe the realtime resource consumption of substrate networks,which can balance the accuracy of resource status and the complexity of the allocation algorithm.A QoS-based Virtual network request(VNR)sorting mechanism is presented to precisely calculate the priority of VNRs and reasonably sort the incoming services.A load-balancing based resource allocation mechanism is designed to avoid unbalanced resource consumption.Especially,the channel interference is considered in the cost of embedding and a collision domain mechanism is introduced to decrease interference.Simulation results demonstrate that the proposed method can provide heterogeneous smart grid businesses with differentiated service,improve the utilization and economic benefits of the network and make the network more balanced. | XU Siya LI Peng QI Feng GUO Shaoyong ZHOU Guiping DENG Wei LI Yueyue | 2019 | Chinese Journal of Electronics2019，28，6： | 1 |
| 17 | Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum显示文摘 | Peng Li Pingan Xia Jie Wen Maiqing Zheng Jilan Chen Jingpeng Zhao Ruirui Jiang Ranran Liu Guiping Zhao | 2009 | Veterinary Microbiology2009，，2： | 1 |
| 18 | Supercritical Carbon Dioxide-Assisted Dispersion of Sodium Benzoate in Polypro- pylene and Crystallization Behavior of the Resulting Polypro- pylene显示文摘 | Li Bin Hu Guohua Cao Guiping | 2006 | JApplPolym Sci2006，102，4： | 1 |
| 19 | Effect of Supercriti- cal Carbon Dioxide-Assisted Nano-Scale Dispersion of Nucle- ating Agents on the Crystallization Behavior and Properties of Polypropylene显示文摘 | Li Bin Hu Guohua Cao Guiping | 2007 | J Supercrit Fluids2007，44，3： | 1 |
| 20 | Mutations in the miRNA165/166 binding site of the HB2 gene result in pleiotropic effects on morphological traits in wheat显示文摘Leaf,spike,stem,and root morphologies are key factors that determine crop growth,development,and productivity.Multiple genes that control these morphological traits have been identified in Arabidopsis,rice,maize,and other plant species.However,little is known about the genomic regions and genes associated with morphological traits in wheat.Here,we identified the ethyl methanesulfonate-derived mutant wheat line M133 that displays multiple morphological changes that include upward-curled leaves,paired spikelets,dwarfism,and delayed heading.Using bulked segregant RNA sequencing(BSR-seq)and a high-resolution genetic map,we identified TraesCS1D02G155200(HBD2)as a potential candidate gene.HB-D2 encodes a class III homeodomain-leucine zipper(HD-ZIP III)transcription factor,and the mutation was located in the miRNA165/166 complementary site,resulting in a resistant allele designated rHb-D2.The relative expression of rHb2 in the mutant plants was significantly higher(P<0.01)than in plants homozygous for the WT allele.Independent resistant mutations that disrupt the miRNA165/166 complementary sites in the A-(rHb-A2)and B-genome(rHb-B2)homoeologs showed similar phenotypic alterations,but the relative intensity of the effects was different.Transgenic plants expressing rHb-D2 gene driven by the maize UBIQUITIN(UBI)promoter showed similar phenotypes to the rHb-D2 mutant.These results confirmed that HB-D2 is the causal gene responsible for the mutant phenotypes.Finally,a survey of 1397 wheat accessions showed that the complementary sites for miRNA165/166 in all three HB2 homoeologs are highly conserved.Our results suggest that HB2 plays an important role in regulating growth and development in wheat. | Dengji Jiang Lei Hua Chaozhong Zhang Hongna Li Zheng Wang Jian Li Guiping Wang Rui Song Tao Shen Hongyu Li Shengsheng Bai Yanna Liu Jian Wang Hao Li Jorge Dubcovsky Shisheng Chen | 2023 | The Crop Journal2023，11，1： | 1 |
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